Management of renin-angiotensin system inhibitors prior to major surgery: insights from the STOP-or-NOT trial. [PDF]
Br J AnaesthStrong recommendations on how to manage renin-angiotensin system inhibitors, including angiotensin-converting enzyme inhibitors and angiotensin receptor blockers, before surgery are lacking because of a lack of evidence, which is mostly limited to data ...
Legrand M, Gayat E.
europepmc +3 more sources
Beyond the Circulating Renin–Angiotensin Aldosterone System [PDF]
Frontiers in Endocrinology, 2014 The activation of the classical renin–angiotensin aldosterone system (RAAS) is known to be involved in the regulation of blood volume and blood pressure and plays an important role in cardiovascular pathology including hypertension and heart failure.
C Walmor, De Mello
openaire +4 more sources
AMPK: a balancer of the renin–angiotensin system [PDF]
Bioscience Reports, 2019 AbstractThe renin–angiotensin system (RAS) is undisputedly well-studied as one of the oldest and most critical regulators for arterial blood pressure, fluid volume, as well as renal function. In recent studies, RAS has also been implicated in the development of obesity, diabetes, hyperlipidemia, and other diseases, and also involved in the regulation ...
Thomas Rousselle +8 more
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Juxtaglomerular apparatus hyperplasia under dual angiotensin blockade. A footprint of adequate RAS inhibition or a concern for renal fibrosis? [PDF]
, 2012 Background: Dual renin-angiotensin system blockade with angiotensin-converting enzyme inhibitors and angiotensin receptor blockers has been advocated to minimize proteinuria. However, recent trials have questioned the renal safety of this approach.
Barat, Antonio +5 more
core +4 more sources
Renin-Angiotensin System: A Review of Historical Perspectives [PDF]
, 2023 The article is a review of publications concerning historical perspectives of the renin-angiotensin system. The discovery of its components is presented in chronological order, beginning with the initial identification of renin and proceeding to the ...
Ivanchenko, Svitlana +2 more
core +2 more sources
Alamandine and Its Receptor MrgD Pair Up to Join the Protective Arm of the Renin-Angiotensin System [PDF]
, 2019 Only a few years ago, alamandine was found to be a member of the protective arm of the renin-angiotensin system. It turned out to be an endogenous ligand of the G protein-coupled receptor MrgD.
Schleifenbaum, Johanna
core +1 more source
Clinical Determinants and Prognostic Implications of Renin and Aldosterone in Patients with Symptomatic Heart Failure [PDF]
, 2020 Aims Activation of the renin-angiotensin-aldosterone system plays an important role in the pathophysiology of heart failure (HF) and has been associated with poor prognosis.
Anker, Stefan D. +17 more
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Effects of Circulating and Local Uteroplacental Angiotensin II in Rat Pregnancy. [PDF]
, 2010 The renin-angiotensin (Ang) system is important during placental development. Dysregulation of the renin-Ang system is important in preeclampsia (PE). Female rats transgenic for the human angiotensinogen gene crossed with males transgenic for the human ...
Brosnihan, KB +12 more
core +1 more source
Pharmacological effects of raas blockade in ischemic nephropathy [PDF]
, 2016 Background: The management of ischemic nephropathy due to atherosclerotic renal artery stenosis has become increasingly conservative in the modern era, with current guidelines recommending optimized medical therapy as the initial step.
Barbano, Biagio +8 more
core +1 more source
Immunohistochemical expression of intrarenal renin angiotensin system components in response to tempol in rats fed a high salt diet [PDF]
, 2017 AIM:To determine the effect of tempol in normal rats fed high salt on arterial pressure and the balance between antagonist components of the renal renin-angiotensin system.METHODS:Sprague-Dawley rats were fed with 8% NaCl high-salt (HS) or 0.4% NaCl ...
Cao, Gabriel Fernando +7 more
core +1 more source