Results 1 to 10 of about 22,102,937 (361)
Juxtaglomerular apparatus hyperplasia under dual angiotensin blockade. A footprint of adequate RAS inhibition or a concern for renal fibrosis? [PDF]
BMC Nephrology, 2012 Background Dual renin-angiotensin system blockade with angiotensin-converting enzyme inhibitors and angiotensin receptor blockers has been advocated to minimize proteinuria. However, recent trials have questioned the renal safety of this approach.
Fernandez-Fernandez Beatriz +5 more
doaj +6 more sources
APOL1 Modulates Renin–Angiotensin System [PDF]
BiomoleculesPatients carrying APOL1 risk alleles (G1 and G2) have a higher risk of developing Focal Segmental Glomerulosclerosis (FSGS); we hypothesized that escalated levels of miR193a contribute to kidney injury by activating renin–angiotensin system (RAS) in the ...
Vinod Kumar +11 more
doaj +2 more sources
Novel Antihypertensive Medications to Target the Renin-Angiotensin System: Mechanisms and Research [PDF]
Reviews in Cardiovascular MedicineAn estimated 1.28 billion individuals in the global population suffer from hypertension. Importantly, uncontrolled hypertension is strongly linked to various cardiovascular and cerebrovascular diseases.
Zhe Jiang, Changlin Zhai, Guanmin Tang
doaj +2 more sources
AMPK: a balancer of the renin–angiotensin system [PDF]
Bioscience Reports, 2019 AbstractThe renin–angiotensin system (RAS) is undisputedly well-studied as one of the oldest and most critical regulators for arterial blood pressure, fluid volume, as well as renal function. In recent studies, RAS has also been implicated in the development of obesity, diabetes, hyperlipidemia, and other diseases, and also involved in the regulation ...
Thomas Rousselle +8 more
openaire +5 more sources
Renin-Angiotensin System: A Review of Historical Perspectives
Galician Medical Journal, 2023 The article is a review of publications concerning historical perspectives of the renin-angiotensin system. The discovery of its components is presented in chronological order, beginning with the initial identification of renin and proceeding to the ...
Olga Kovalyova +2 more
doaj +1 more source
Beyond the Circulating Renin–Angiotensin Aldosterone System [PDF]
Frontiers in Endocrinology, 2014 The activation of the classical renin–angiotensin aldosterone system (RAAS) is known to be involved in the regulation of blood volume and blood pressure and plays an important role in cardiovascular pathology including hypertension and heart failure.
C Walmor, De Mello
openaire +4 more sources
Renin Angiotensin System and Covid-19 Infection [PDF]
Advanced Pharmaceutical Bulletin, 2022 Purpose The new coronavirus, called SARS-CoV-2, is responsible for the recent global pandemic COVID-19. The status of the global pandemic COVID-19 is currently underway, and the virus has caused about 1.11 million deaths.
Francesco Ferrara, Antonio Vitiello
doaj +1 more source
Frontiers in Nutrition, 2021 Vitamin K2 (VK2), found to act to treat hypertension, has been widely used in the food and pharmaceutical industries nowadays. However, the potential targets and molecular mechanisms of VK2 for salt-sensitive hypertension have not been fully investigated.
Tian-hao Liu +7 more
doaj +1 more source
Clinical Determinants and Prognostic Implications of Renin and Aldosterone in Patients with Symptomatic Heart Failure [PDF]
, 2020 Aims Activation of the renin-angiotensin-aldosterone system plays an important role in the pathophysiology of heart failure (HF) and has been associated with poor prognosis.
Anker, Stefan D. +17 more
core +4 more sources
Hepcidin is potential regulator for renin activity
PLoS ONE, 2022 An association between genetic variants in the genes HFE, HJV, BMP4 and arterial hypertension has been shown earlier. Proteins encoded by these genes participate in the signalling routes leading eventually to the production of the peptide hormone ...
Jaakko Piesanen +7 more
doaj +2 more sources