Results 311 to 320 of about 141,530 (342)
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Drugs targeting the renin–angiotensin–aldosterone system
Nature Reviews Drug Discovery, 2002Effective antihypertensive therapy has made a major contribution to the reductions in the morbidity and mortality of cardiovascular disease that have been achieved since the 1960s. However, blood-pressure control with conventional drugs has not succeeded in reducing cardiovascular disease risks to levels seen in normotensive persons. Drugs that inhibit
Mohammad Amin, Zaman +2 more
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Renin-Angiotensin-Aldosterone System
Abstract Renin-angiotensin-aldosterone systems exist in various tissues throughout the body, including the kidneys, adrenal gland, cardiovascular system, and nervous system, where it may be involved in local regulation of vascular tone. Renin causes angiotensin to be cleaved into angiotensin I, which is then converted to angiotensin II ...Marwa El-Sabbahy, Karim Fikry
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Renin-Angiotensin-Aldosterone System in Hypertrophic Cardiomyopathy
Kardiologiia, 2014Keeping in mind an important role of renin-angiotensin aldosterone system (RAS) in developing of cardiac remodeling and fibrosis, genetic polymorphisms coding its components could have influence with clinical variants of the course. Biomarkers could appear predictors of adverse.
M V, Kozhevnikova +4 more
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Key developments in renin–angiotensin–aldosterone system inhibition
Nature Reviews Nephrology, 2012The renin-angiotensin-aldosterone system (RAAS) was initially thought to be fairly simple. However, this idea has been challenged following the development of RAAS blockers, including renin inhibitors, angiotensin-converting-enzyme (ACE) inhibitors, type 1 angiotensin II (AT(1))-receptor blockers and mineralocorticoid-receptor antagonists. Consequently,
Seva Pessoa, Bruno +5 more
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Hypertension and the Renin–Angiotensin–Aldosterone System
2018Hypertension is defined as a systolic blood pressure > 140 mmHg or a diastolic blood pressure > 90 mmHg. Renin is a key enzyme of the renin-angiotensin-aldosterone system (RAAS), cleaving angiotensinogen to angiotensin I and, thereby, having an impact on the synthesis rate of the effector hormone of the RAAS, angiotensin II. The RAAS is a hormone
Kaschina, Elena +2 more
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Recent Research Advances in Renin-Angiotensin-Aldosterone System Receptors
Current Hypertension Reports, 2020K. Azushima +3 more
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The Role of the Renin-Angiotensin-Aldosterone System in Preeclampsia: a Review
Current Hypertension Reports, 2020P. Gathiram, J. Moodley
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Role of the renin–angiotensin–aldosterone system in bone metabolism
Journal of Bone and Mineral Metabolism, 2020Caiyan Mo +3 more
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