Results 71 to 80 of about 17,358,252 (203)

The association of hypertension with renin–angiotensin system gene polymorphisms in the Lebanese population [PDF]

, 2011
Aim: The study objective was to examine the association of hypertension in the Lebanese population with three renin–angiotensin system gene polymorphisms (RAS): angiotensin-converting enzyme (ACE), angiotensinogen (AGT) and angiotensin-receptor type 1 ...
Saab, YB, YB Saab, Saab, Y.B., Gard, Paul, ADJ Overall, Gard, PR, Overall, Andrew, PR Gard, Overall, ADJ   +8 more
core   +1 more source

Aliskiren – an orally active renin inhibitor. Review of pharmacology, pharmacodynamics, kinetics, and clinical potential in the treatment of hypertension

Vascular Health and Risk Management, 2008
Kristina AllikmetsDepartment of Drug Development and Medical Affairs, Nycomed Group, Roskilde, DenmarkAbstract: The importance of renin-angiotensin-aldosterone system (RAAS) in diseases such as hypertension, congestive heart failure and chronic renal ...
Kristina Allikmets
doaj  

Role of Nonclassical Renin-angiotensin system Axis In Renal Fibrosis

Frontiers in Physiology, 2015
The renin–angiotensin system (RAS) is a major regulator of renal fibrosis. Besides the classical renin/Angiotensin-converting enzyme 2 (ACE2)/angiotensin II (Ang II)/AT1 and AT2 axis, multiple new axes have been recently described.
Linli eLv, Bi-Cheng eLiu
doaj   +1 more source

Role of cGMP as second messenger of adenosine in the inhibition of renin release [PDF]

, 1988
Adenosine is known to be a potent inhibitor of renin release from the kidneys. The aim of this study was to investigate the transmembrane signalling avenue that the second messenger of adenosine causes inhibition of renal renin release.
Kurtz, Armin, Della Bruna, Roberto, Della Bruna, R., Bauer, Christian, Pfeilschifter, Josef, Pfeilschifter, J.   +5 more
core   +1 more source

The renin angiotensin system in the development of cardiovascular disease: role of aliskiren in risk reduction

Vascular Health and Risk Management, 2008
Paolo Verdecchia1, Fabio Angeli1, Giovanni Mazzotta1, Giorgio Gentile2, Gianpaolo Reboldi21Department of Cardiology, Clinical Research Unit ‘Preventive Cardiology’, Hospital ‘Santa Maria della Misericordia’, and Fondazione Umbra ...
Paolo Verdecchia, Fabio Angeli, Giovanni Mazzotta, Giorgio Gentile, Gianpaolo Reboldi   +4 more
doaj  

Endothelial cells modulate renin secretion from isolated mouse juxtaglomerular cells [PDF]

, 1991
Utilizing cocultures of mouse renal juxtaglomerular cells with bovine microvascular endothelial cells, we have examined whether endothelial cells exert direct influence on renin secretion from renal juxtaglomerular cells.
Kaissling, Brigitte, Kurtz, Armin, Baier, Wolfgang, W Baier, R Busse, A Kurtz, Busse, Rudi, B Kaissling   +7 more
core   +1 more source

Features of Neurohumoral Relations in Diastolic Dysfunction of the Heart in Adolescents with Myocardial Pathology

Zdorovʹe Rebenka, 2015
It is found that only in adolescents with I type left ventricular diastolic dysfunction, there is a significant activation of sympathoadrenal system, and in patients with type II and III, increasing activation of the renin-angiotensin-aldosterone system ...
L.F. Bohmat, V.V. Nikonovа, S.R. Tolmachevа, T.S. Vvedenskaia   +3 more
doaj   +1 more source

Local renin-angiotensin systems [PDF]

Molecular and Cellular Biochemistry, 1996
The existence of a local cardiovascular renin-angiotensin system (RAS) is often invoked to explain the long-term beneficial effects of RAS inhibitors in heart failure and hypertension. The implicit assumption is that all components of the RAS are synthesized in situ, so that local angiotensin II formation may occur independently of the circulating RAS.
openaire   +2 more sources

Role of monocytes/macrophages in renin-angiotensin system-induced hypertension and end organ damage

, 2023
The renin-angiotensin system (RAS) is a central modulator of cardiovascular physiology. Pathophysiology of hypertension is commonly accompanied by hyper-activation of RAS.
Barhoumi, Tlili, Todryk, Stephen
core   +1 more source

Upregulation of angiotensin-(1-7) formation in human podocytes - enzyme activity assay upon fluid flow shear stress.

PLoS ONE
The renin-angiotensin system is known for its role in renal physiology by regulating renal hemodynamics and natriuresis. Overactivation of this system exerts pathological effects in the kidney, primarily mediated by its main effector peptide angiotensin ...
Debora Kaiser-Graf, Oliver Domenig, Marko Poglitsch, Reinhold Kreutz, Juliane Bolbrinker   +4 more
doaj   +1 more source