Results 61 to 70 of about 17,358,252 (203)

High salt intake damages the heart through activation of cardiac (pro) renin receptors even at an early stage of hypertension. [PDF]

PLoS ONE, 2015
It has not yet been fully elucidated whether cardiac tissue levels of prorenin, renin and (P)RR are activated in hypertension with a high salt intake.
Yuka Hayakawa, Takuma Aoyama, Chiharu Yokoyama, Chihiro Okamoto, Hisaaki Komaki, Shingo Minatoguchi, Masamitsu Iwasa, Yoshihisa Yamada, Itta Kawamura, Masanori Kawasaki, Kazuhiko Nishigaki, Atsushi Mikami, Fumiaki Suzuki, Shinya Minatoguchi   +13 more
doaj   +1 more source

Pharmacology of the renin-angiotensin system.

Folia Pharmacologica Japonica, 1994
Recent developments in the techniques of molecular biology and the availability of inhibitors of the renin-angiotensin system have provided new insight into renin-angiotensin research. The control mechanism of renin release and the metabolism of circulating renin have been well characterized on the molecular level. Angiotensin II has been shown to play
KIM, Shokei, YAMAMOTO, Kenjiro
openaire   +3 more sources

Effect of a SGLT2 inhibitor on the systemic and intrarenal renin–angiotensin system in subtotally nephrectomized rats

Journal of Pharmacological Sciences, 2018
We aimed to examine the effects of a sodium glucose co-transporter 2 (SGLT2) inhibitor on systemic and intrarenal renin–angiotensin system (RAS) in subtotally nephrectomized non-diabetic rats, a model of chronic kidney disease (CKD).
Lei Li, Yoshio Konishi, Takashi Morikawa, Yifan Zhang, Chizuko Kitabayashi, Hideki Kobara, Tsutomu Masaki, Daisuke Nakano, Hirofumi Hitomi, Hiroyuki Kobori, Akira Nishiyama   +10 more
doaj   +1 more source

Dietary Potassium Downregulates Angiotensin-I Converting Enzyme, Renin, and Angiotensin Converting Enzyme 2

Frontiers in Pharmacology, 2020
BackgroundThe importance of dietary potassium in health and disease has been underestimated compared with that placed on dietary sodium. Larger effort has been made on reduction of sodium intake and less on the adequate dietary potassium intake, although
Carlos P. Vio, Carlos P. Vio, Pedro Gallardo, Carlos Cespedes, Carlos Cespedes, Daniela Salas, Jessica Diaz-Elizondo, Natalia Mendez   +7 more
doaj   +1 more source

Elevated Serum Angiotensin Converting Enzyme Levels As A Reflection Of Bone Marrow Renin-Angiotensin System Activation In Multiple Myeloma

, 2012
Introduction: Angiotensin converting enzyme (ACE) is a circulating enzyme that participates in the body's renin-angiotensin system (RAS) and is localized on the endothelial cell surface in the lung and other vascular beds.
Celebi, Harika, Balcik, Ozlem Sahin, Albayrak, Aynur, Albayrak, Murat, Yokus, Osman, Celik, Tugrul, Sayilir, Abdurrahim, Yesil, Yusuf   +7 more
core   +1 more source

Central injection of captopril inhibits the blood pressure response to intracerebroventricular choline

Brazilian Journal of Medical and Biological Research, 2001
In the present study, we investigated the involvement of the brain renin-angiotensin system in the effects of central cholinergic stimulation on blood pressure in conscious, freely moving normotensive rats. In the first step, we determined the effects of
N. Isbil-Buyukcoskun, G. Gulec, K. Ozluk, I.H. Ulus   +3 more
doaj   +1 more source

Local Hematopoietic Renin-Angiotensin System in Myeloid Versus Lymphoid Hematological Neoplastic Disorders

, 2013
There is preliminary evidence that the local renin-angiotensin system (RAS) could affect neoplastic hematopoiesis. The aim of this study is to search messenger RNA (mRNA) expressions of the essential RAS elements in myeloid and lymphoid hematological ...
Sayinalp, Nilgun, Goker, Hakan, Ng, Ozden Hatirnaz, Aksu, Salih, Haznedaroglu, Ibrahim C., Buyukasik, Yahya, Tatonyan, Suzin Catal, Ozcebe, Osman I., ÖZCEBE, OSMAN İLHAMİ, Erbilgin, Yucel, Ozbek, Ugur, Uz, Burak, Sayitoglu, Muge   +12 more
core   +1 more source

Concomitant calcium entry blockade and inhibition of the renin-angiotensin system: a rational and effective means for treating hypertension

, 2008
Pharmacological treatment of hypertension is effective in preventing cardiovascular and renal complications. Calcium antagonists (CAs) and blockers of the renin-angiotensin system [angiotensin-converting enzyme (ACE) inhibitors and angiotensin II ...
Gojanovic, B., Feihl, F., Liaudet, L., Waeber, B.   +3 more
core   +1 more source

The structure of testis angiotensin-converting enzyme (tACE-g13) in complex with the inhibitor RXPA380 [PDF]

, 2006
Includes bibliographical references.Angiotensin-converting enzyme (ACE), a zinc metalloprotease, is a key regulator of the mammalian renin-angiotensin system (RAS) Primarily, ACF is a dipeptidl peptidase which cleaves angiotensin I to produce angiotensin
Chitapi, Itai
core   +1 more source

Local renin-angiotensin system regulates left ventricular hypertrophy induced by swimming training independent of circulating renin: a pharmacological study

, 2009
Introduction. This study addressed the role of the local renin-angiotensin system (RAS) in the left ventriular hypertropy (LVH) induced by swimming training using pharmacological blockade. Materials and methods.
CERENCIO, Marcela, OLIVEIRA, Edilamar M., KRIEGER, Jose E., SASAKI, Mauricio S., BARAUNA, Valerio G.   +4 more
core   +1 more source