Results 41 to 50 of about 98,465 (163)

The Frail Renin-Angiotensin System [PDF]

Clinics in Geriatric Medicine, 2011
Over the last few decades, the understanding of the renin-angiotensin system (RAS) has advanced dramatically. RAS is now thought to play a crucial role in physiologic and pathophysiologic mechanisms in almost every organ system and is a key regulator of hypertension, cardiovascular disease, and renal function.
openaire   +2 more sources

High salt intake damages the heart through activation of cardiac (pro) renin receptors even at an early stage of hypertension. [PDF]

PLoS ONE, 2015
It has not yet been fully elucidated whether cardiac tissue levels of prorenin, renin and (P)RR are activated in hypertension with a high salt intake.
Yuka Hayakawa, Takuma Aoyama, Chiharu Yokoyama, Chihiro Okamoto, Hisaaki Komaki, Shingo Minatoguchi, Masamitsu Iwasa, Yoshihisa Yamada, Itta Kawamura, Masanori Kawasaki, Kazuhiko Nishigaki, Atsushi Mikami, Fumiaki Suzuki, Shinya Minatoguchi   +13 more
doaj   +1 more source

Effect of a SGLT2 inhibitor on the systemic and intrarenal renin–angiotensin system in subtotally nephrectomized rats

Journal of Pharmacological Sciences, 2018
We aimed to examine the effects of a sodium glucose co-transporter 2 (SGLT2) inhibitor on systemic and intrarenal renin–angiotensin system (RAS) in subtotally nephrectomized non-diabetic rats, a model of chronic kidney disease (CKD).
Lei Li, Yoshio Konishi, Takashi Morikawa, Yifan Zhang, Chizuko Kitabayashi, Hideki Kobara, Tsutomu Masaki, Daisuke Nakano, Hirofumi Hitomi, Hiroyuki Kobori, Akira Nishiyama   +10 more
doaj   +1 more source

Dietary Potassium Downregulates Angiotensin-I Converting Enzyme, Renin, and Angiotensin Converting Enzyme 2

Frontiers in Pharmacology, 2020
BackgroundThe importance of dietary potassium in health and disease has been underestimated compared with that placed on dietary sodium. Larger effort has been made on reduction of sodium intake and less on the adequate dietary potassium intake, although
Carlos P. Vio, Carlos P. Vio, Pedro Gallardo, Carlos Cespedes, Carlos Cespedes, Daniela Salas, Jessica Diaz-Elizondo, Natalia Mendez   +7 more
doaj   +1 more source

Renal Renin-Angiotensin System [PDF]

, 2004
The cardinal role of the intrarenal renin-angiotensin system (RAS) in the control of sodium excretion and the pathophysiology of hypertension continues to receive increased attention. In addition to its very powerful vasoconstrictor action, angiotensin (Ang) II exerts important actions on tubular transport function and several recent studies have ...
Atsuhiro, Ichihara, Hiroyuki, Kobori, Akira, Nishiyama, L Gabriel, Navar   +3 more
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Central injection of captopril inhibits the blood pressure response to intracerebroventricular choline

Brazilian Journal of Medical and Biological Research, 2001
In the present study, we investigated the involvement of the brain renin-angiotensin system in the effects of central cholinergic stimulation on blood pressure in conscious, freely moving normotensive rats. In the first step, we determined the effects of
N. Isbil-Buyukcoskun, G. Gulec, K. Ozluk, I.H. Ulus   +3 more
doaj   +1 more source

Aliskiren – an orally active renin inhibitor. Review of pharmacology, pharmacodynamics, kinetics, and clinical potential in the treatment of hypertension

Vascular Health and Risk Management, 2008
Kristina AllikmetsDepartment of Drug Development and Medical Affairs, Nycomed Group, Roskilde, DenmarkAbstract: The importance of renin-angiotensin-aldosterone system (RAAS) in diseases such as hypertension, congestive heart failure and chronic renal ...
Kristina Allikmets
doaj  

Role of Nonclassical Renin-angiotensin system Axis In Renal Fibrosis

Frontiers in Physiology, 2015
The renin–angiotensin system (RAS) is a major regulator of renal fibrosis. Besides the classical renin/Angiotensin-converting enzyme 2 (ACE2)/angiotensin II (Ang II)/AT1 and AT2 axis, multiple new axes have been recently described.
Linli eLv, Bi-Cheng eLiu
doaj   +1 more source

The renin angiotensin system in the development of cardiovascular disease: role of aliskiren in risk reduction

Vascular Health and Risk Management, 2008
Paolo Verdecchia1, Fabio Angeli1, Giovanni Mazzotta1, Giorgio Gentile2, Gianpaolo Reboldi21Department of Cardiology, Clinical Research Unit ‘Preventive Cardiology’, Hospital ‘Santa Maria della Misericordia’, and Fondazione Umbra ...
Paolo Verdecchia, Fabio Angeli, Giovanni Mazzotta, Giorgio Gentile, Gianpaolo Reboldi   +4 more
doaj  

Features of Neurohumoral Relations in Diastolic Dysfunction of the Heart in Adolescents with Myocardial Pathology

Zdorovʹe Rebenka, 2015
It is found that only in adolescents with I type left ventricular diastolic dysfunction, there is a significant activation of sympathoadrenal system, and in patients with type II and III, increasing activation of the renin-angiotensin-aldosterone system ...
L.F. Bohmat, V.V. Nikonovа, S.R. Tolmachevа, T.S. Vvedenskaia   +3 more
doaj   +1 more source