Results 21 to 30 of about 98,465 (163)
Pathological Role of Angiotensin II in Severe COVID-19
TH Open, 2020 The activated renin–angiotensin system induces a prothrombotic state resulting from the imbalance between coagulation and fibrinolysis. Angiotensin II is the central effector molecule of the activated renin–angiotensin system and is degraded by the ...
Wolfgang Miesbach
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BMC Public Health, 2021 Background The risk of heart failure is disproportionately high among the socioeconomically disadvantaged. Furthermore, socioeconomically deprived patients are at risk of inequitable access to heart failure treatment and poor outcomes.
Anna Ohlsson +4 more
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Direct pro-inflammatory effects of prorenin on microglia.
PLoS ONE, 2014 Neuroinflammation has been implicated in hypertension, and microglia have been proposed to play an important role in the progression of this disease. Here, we have studied whether microglia are activated within cardiovascular regulatory area(s) of the ...
Peng Shi +8 more
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Arterial Hypertension, 2021 Kidneys produce a number of substances that affect intrarenal blood circulation; however, the key system that regulates blood flow in both general and local circulation (including the renal circulation) is the renin-angiotensinaldosterone system (RAAS ...
Natalia Butt-Hussaim, Jacek Manitius
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Aging and the Renin-Angiotensin System [PDF]
Hypertension, 2012 Angiotensin II (Ang II), the dominant effector molecule of the renin-angiotensin system (RAS), exerts its effects on binding of 2 pharmacologically distinct rhodopsin-like G protein–associated receptors, the type 1 and the type 2 (AT1 and AT2) receptors.1 Human cells express a single AT1 receptor, whereas 2 isoforms, AT1A and AT1B with 95% of amino ...
Conti, Sara +2 more
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THE INFLUENCE OF TISSUE ANGIOTENSINS ON ELEMENTS OF THE CARDIOVASCULAR SYSTEM (LECTURE)
Байкальский медицинский журналRelevance. The renin-angiotensin system is today one of the oldest and most studied peptide cascades. Understanding the operation of this system is an urgent task for study in medical higher education institutions.
Liudmila O Gutsol, Irina E Egorova
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The intracrine renin–angiotensin system [PDF]
Clinical Science, 2012 The RAS (renin–angiotensin system) is one of the earliest and most extensively studied hormonal systems. The RAS is an atypical hormonal system in several ways. The major bioactive peptide of the system, AngII (angiotensin II), is neither synthesized in nor targets one specific organ.
Kumar, R. +4 more
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Local renin-angiotensin systems [PDF]
Molecular and Cellular Biochemistry, 1996 The existence of a local cardiovascular renin-angiotensin system (RAS) is often invoked to explain the long-term beneficial effects of RAS inhibitors in heart failure and hypertension. The implicit assumption is that all components of the RAS are synthesized in situ, so that local angiotensin II formation may occur independently of the circulating RAS.
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Roles and functions of Atp6ap2 in the brain
Neural Regeneration Research, 2018 The classical renin-angiotensin system (RAS) in the body has been studied intensively in the last decades, since it is known that this system is involved in the regulation of blood pressure.
Alexander Bracke +1 more
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Case Reports in Nephrology, 2020 The renin-angiotensin system plays a very critical role in hypertension, diabetes, and kidney and heart diseases. The blockade of the renin-angiotensin system results in the prevention of progression of renal and cardiac damage.
Avantika Chenna +7 more
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