Results 81 to 90 of about 17,358,252 (203)

Present and Future in the Treatment of Diabetic Kidney Disease

Journal of Diabetes Research, 2015
Diabetic kidney disease is the leading cause of end-stage renal disease. Albuminuria is recognized as the most important prognostic factor for chronic kidney disease progression.
Borja Quiroga, David Arroyo, Gabriel de Arriba   +2 more
doaj   +1 more source

Collecting Duct Nitric Oxide Synthase 1ß Activation Maintains Sodium Homeostasis During High Sodium Intake Through Suppression of Aldosterone and Renal Angiotensin II Pathways

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
BackgroundDuring high sodium intake, the renin‐angiotensin‐aldosterone system is downregulated and nitric oxide signaling is upregulated in order to remain in sodium balance.
Kelly A. Hyndman, Elena V. Mironova, Jorge F. Giani, Courtney Dugas, Jessika Collins, Alicia A. McDonough, James D. Stockand, Jennifer S. Pollock   +7 more
doaj   +1 more source

Adenoviral delivery of angiotensin-(1-7) or angiotensin-(1-9) inhibits cardiomyocyte hypertrophy via the mas or angiotensin Type 2 receptor [PDF]

, 2012
The counter-regulatory axis of the renin angiotensin system peptide angiotensin-(1-7) [Ang-(1-7)] has been identified as a potential therapeutic target in cardiac remodelling, acting via the mas receptor.
Nicklin Stuart A., Almalik Abdulaziz, Bruno M D C Godinho, Flores-Muñoz Monica, Flores-Muñoz, M., Almalik, A., Nicklin, S.A., Monica Flores-Muñoz, Stuart A Nicklin, Abdulaziz Almalik, Godinho, B.M.D.C., Godinho Bruno M. D. C.   +11 more
core   +2 more sources

Transgenic amplification of glucocorticoid action in adipose tissue causes high blood pressure in mice [PDF]

, 2003
Obesity is closely associated with the metabolic syndrome, a combination of disorders including insulin resistance, diabetes, dyslipidemia, and hypertension.
Kenyon, C J, Joel K. Elmquist, Elmquist, Joel K., Flier, Jeffrey S., Jonathan R. Seckl, Yamamoto, H, Yamamoto, Hiroshi, Mullins, J J, John J. Mullins, Shinyama, H, Shinyama, Hiroshi, Masuzaki, H, Nicholas M. Morton, Janice M. Paterson, Paterson, Janice M., Sharp, M G F, Jeffrey S. Flier, Seckl, J R, Sharp, Matthew G. F., Masuzaki, Hiroaki, Paterson, J M, Matthew G.F. Sharp, Seckl, Jonathan R., Hiroshi Yamamoto, Morton, Nicholas M., Stewart Fleming, Elmquist, J K, Morton, N M, Hiroaki Masuzaki, Flier, J S, Mullins, John J., Fleming, S, Hiroshi Shinyama, Fleming, Stewart, Kenyon, Christopher J., Christopher J. Kenyon   +35 more
core   +1 more source

Aliskiren, Fosinopril, and Their Outcome on Renin-Angiotensin-Aldosterone System (RAAS) in Rats with Thyroid Dysfunction

International Journal of Endocrinology, 2019
Background and Objectives. Thyroid hormones have an important role in the growth and development of various tissues including the kidney, which is the major site of renin release and the consequent angiotensin and aldosterone formation.
Susan A. S. Farhadi, Kawa F. Dizaye
doaj   +1 more source

Genetic polymorphisms of the renin-angiotensin system in preterm delivery and premature rupture of membranes

, 2007
Introduction. Premature rupture of membranes (PRM) is a late pregnancy complication commonly associated with preterm delivery (PD). Although several markers related to the renin-angiotensin system (RAS) have been evaluated in certain pregnancy ...
Mendoza-Carrera, F., Valdez-Velazquez, L.L., Quintero-Ramos, A., Rivas, F., Rivas Jr., F., Olivares, N., Perez, S.A., Celis, A., Vazquez, O.F., Montoya-Fuentes, H.   +9 more
core   +1 more source

Associations of genetic polymorphisms in the renin-angiotensin system with central aortic and ambulatory blood pressure in type 2 diabetic patients

, 2014
Patients with type 2 diabetes (T2D) are at high risk of developing hypertension and related cardiovascular disease. The renin-angiotensin system (RAS) plays a central role in regulation of blood pressure (BP).
Länne, Toste,, Östgren, Carl Johan,, Ljungberg, Liza U.,, Nyström, Fredrik H.,, Nyström, Fredrik H,, Johan Östgren, Carl,, Ljungberg, Liza,   +6 more
core   +1 more source

Manipulation of the Renin-Angiotensin System [PDF]

Circulation, 2001
Since the initial description of angiotensin II–mediated hypertension >40 years ago, basic and clinical investigations of the renin-angiotensin system (RAS) have resulted in a broader understanding of cardiovascular pathophysiology and significant advances in therapy.
openaire   +2 more sources

Thyroid Disorders Change the Pattern of Response of Angiotensinase Activities in the Hypothalamus-Pituitary-Adrenal Axis of Male Rats

Frontiers in Endocrinology, 2018
Thyroid disorders affect the hypothalamic-pituitary-adrenal axis with important consequences on the cardiovascular function in which the renin-angiotensin system plays a major role.
Ana B. Segarra, Isabel Prieto, Magdalena Martínez-Cañamero, Marc de Gasparo, Juan de Dios Luna, Manuel Ramírez-Sánchez   +5 more
doaj   +1 more source

The renin angiotensin aldosterone system

Pflügers Archiv - European Journal of Physiology
AbstractIn this review, we will cover (i) the proteolytic cascade of the RAAS, (ii) its regulation by multiple feedback-controlled parameters, and (iii) the major effects of the RAAS. For the effects of the RAAS, we focus on the role of the RAAS in the regulation of volume homeostasis and vascular tone, as major determinants of arterial blood pressure.
Triebel, Hannah, Castrop, Hayo
openaire   +2 more sources