Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017 BackgroundGuidelines for hypertension vary in their preference for initial combination therapy or initial monotherapy, stratified by patient profile; therefore, we compared the efficacy and tolerability of these approaches.
Thomas M. MacDonald +13 more
doaj +1 more source
Proteomic prediction and Renin angiotensin aldosterone system Inhibition prevention Of early diabetic nephRopathy in TYpe 2 diabetic patients with normoalbuminuria (PRIORITY): essential study design and rationale of a randomised clinical multicentre trial [PDF]
, 2016 Introduction: Diabetes mellitus affects 9% of the European population and accounts for 15% of healthcare expenditure, in particular, due to excess costs related to complications.
Beige, Joachim +14 more
core +4 more sources
The Effect of High Dose Total Body Irradiation on ACTH, Corticosterone, and Catecholamines in the Rat [PDF]
, 2011 Total body irradiation (TBI) or partial body irradiation is a distinct risk of accidental, wartime, or terrorist events. Total body irradiation is also used as conditioning therapy before hematopoietic stem cell transplantation.
Bruder, Eric D. +4 more
core +2 more sources
Therapeutic potential of the renin angiotensin system in ischaemic stroke [PDF]
, 2016 The renin angiotensin system (RAS) consists of the systemic hormone system, critically involved in regulation and homeostasis of normal physiological functions [i.e.
Arroja, Mariana Moreira Coutinho +2 more
core +1 more source
Effect of Accessory Renal Arteries on Essential Hypertension and Related Mechanisms
Journal of the American Heart Association: Cardiovascular and Cerebrovascular DiseaseBackground This case‐control study aimed to determine whether there were differences between patients with essential hypertension with accessory renal arteries (ARAs) and those without ARAs.
Fengyuan Wu +9 more
doaj +1 more source
Protein Kinase G Is Involved in Acute but Not in Long-Term Regulation of Renin Secretion
Frontiers in Pharmacology, 2019 Pharmacological inhibition of the renin–angiotensin–aldosterone system (RAAS) is, in combination with diuretics, the first-choice treatment for hypertension, although 10–20% of patients do not respond adequately.
Andrea Schramm +5 more
doaj +1 more source
Angiotensin type-2 (AT-2)-receptor activation reduces renal fibrosis in cyclosporine nephropathy: evidence for blood-pressure independent effect [PDF]
, 2016 Compound 21 (C21), selective agonist of AT2 receptors, shows antinflammatory effects in hypertension and nephroprotection in diabetes. The aim of this study was to evaluate the effects of C21 in cyclosporine nephropathy, which is characterized mainly by ...
Carletti, R +5 more
core +1 more source
Different behaviour of the N-terminal and C-terminal fragment of proatrial natriuretic factor in plasma of healthy subjects as well as of patients with cirrhosis [PDF]
, 1990 N-terminal (atrial natriuretic factor (ANF) 1-98) and C-terminal (ANF 99-126) fragments of proatrial natriuretic factor (NTA and CTA, respectively) were determined in plasma of healthy subjects adopting different postures and in patients with cirrhosis ...
Arendt, Rainer M. +5 more
core +1 more source
Animal, 2009 If ewes consumed a high-salt diet or saltbush during the last 3 months of pregnancy and for 3 weeks after birth, we expected the renin activity of their lamb to be suppressed at birth and at 3 weeks of age.
M.A. Chadwick +3 more
doaj +1 more source