Results 281 to 290 of about 3,459,561 (335)
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Clinical Science, 1973
1. To examine the substrate specificity of renin a series of analogues of a noctapeptide previously shown to be an effective substrate (Skeggs, Lentz, Kahn & Hochstrasser, 1968) were synthesized. 2. These peptides were studied both with respect to their actions as competitive inhibitors and as substrates. 3.
K, Poulsen, J A, Burton, E, Haber
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1. To examine the substrate specificity of renin a series of analogues of a noctapeptide previously shown to be an effective substrate (Skeggs, Lentz, Kahn & Hochstrasser, 1968) were synthesized. 2. These peptides were studied both with respect to their actions as competitive inhibitors and as substrates. 3.
K, Poulsen, J A, Burton, E, Haber
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Nihon rinsho. Japanese journal of clinical medicine, 1985
Infusion of H.261, the inhibitor of human renin in the baboon, lowered blood angiotensin I, plasma angiotensin II, and arterial pressure suggesting that in the sodium-depleted state angiotensin II contributes to the maintenance of arterial pressure. In a second experiment dose-response infusions of angiotensin II were given in conscious sodium-depleted
T, Ogihara, Y, Kumahara
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Infusion of H.261, the inhibitor of human renin in the baboon, lowered blood angiotensin I, plasma angiotensin II, and arterial pressure suggesting that in the sodium-depleted state angiotensin II contributes to the maintenance of arterial pressure. In a second experiment dose-response infusions of angiotensin II were given in conscious sodium-depleted
T, Ogihara, Y, Kumahara
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Renin inhibitors, clinical experience
Journal of Molecular Medicine, 2008The inhibition of the renin-angiotensin system is one of the most commonly utilized ways to lower blood pressure in patients with arterial hypertension. Up till now, angiotensin-converting enzyme inhibitors as well as angiotensin receptor blockers are the established inhibitors of this system, and both classes are used in clinical routine.
Dirk, Westermann +3 more
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SYNTHESIS OF RENIN INHIBITORS A REVIEW
Acta Medica Scandinavica, 1977SummaryThis short review describes how competitive inhibitors were synthesized and how the solubility was increased in order to make them effective at physiological pH. Their use for in vitro and in vivo inhibition of renin is discussed and their use for purification of renin demonstrated.
K, Poulsen, J, Burton, E, Haber
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RENIN INHIBITION: IMMUNOLOGICAL PROCEDURES AND RENIN INHIBITOR PEPTIDES
Fundamental & Clinical Pharmacology, 1989Summary— Renin inhibitors represent an alternative to angiotensin‐converting enzyme inhibitors (ACEI) for the treatment of hypertension. They inhibit the renin‐angiotensin system at its first and rate limiting step, the renin‐angiotensinogen reaction. Passive administration of angiotensinogen or renin antibodies lowers blood pressure in primates to the
P, Corvol, J, Menard
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Inhibitors of Renin: Present and Future
Clinical and Experimental Hypertension. Part A: Theory and Practice, 1983Four classes of compounds have been demonstrated to be renin inhibitors of high potency: specific antibody, general peptide inhibitors of acid proteases, analogs of angiotensinogen and peptides that are related to the amino-terminal sequence of renin's precursor (Pro-renin).
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Hemodynamic Effects of Renin Inhibitors
American Journal of Nephrology, 1996Renin inhibitors may offer an exciting new therapeutic means of blocking the action of the renin-angiotensin-aldosterone system. These compounds interfere with the first, rate-limiting step in the synthesis of angiotensin II by binding directly to the highly specific enzyme, renin.
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