Results 71 to 80 of about 756,250 (282)

Design and Preparation of Potent, Nonpeptidic, Bioavailable Renin Inhibitors

, 2009
Starting from known piperidine renin inhibitors, a new series of 3,9-diazabicyclo[3.3.1]nonene derivatives was rationally designed and prepared. Optimization of the positions 3, 6, and 7 of the diazabicyclonene template led to potent renin inhibitors ...
Walter Fischli (1288752), Alexander Treiber (1288749), Daniel Bur (630249), Olivier Corminboeuf (2358277), Sylvia Richard-Bildstein (2366851), Thierry Sifferlen (2366836), Beat Steiner (458018), Olivier Bezençon (2366833), Corinna Grisostomi (2366845), Lars Prade (2366830), Thomas Weller (1288761), Christoph Boss (1288764), Luboš Remeň (2366839), Christoph Binkert (1288755), Stéphane Delahaye (2366842), Panja Strickner (2366848), Patrick Hess (458016), Hess, Patrick (author), Bur, Daniel (author), Sifferlen, Thierry (author), Grisostomi, Corinna (author), Corminboeuf, Olivier (author), Weller, Thomas (author), Fischli, Walter (author), Richard-Bildstein, Sylvia (author), Boss, Christoph (author), Prade, Lars (author), Bezençon, Olivier (author), Steiner, Beat (author), Remeň, Luboš (author), Delahaye, Stéphane (author), Treiber, Alexander (author), Strickner, Panja (author), Binkert, Christoph (author)   +33 more
core   +1 more source

Epidemiology of hospitalized heart failure in France based on national data over 10 years, 2012–2022

ESC Heart Failure, Volume 12, Issue 2, Page 1283-1294, April 2025.
Abstract Aims We aim to describe the incidence of HF hospitalization in France in the post‐pandemic era, the prevalence of HF cases and patients' characteristics, management and outcomes while focusing on sex, age and socio‐economic differences and to analyse time‐trends between 2012 and 2022.
Valérie Olié, Richard Isnard, Françoise Pousset, Clémence Grave, Jacques Blacher, Amélie Gabet   +5 more
wiley   +1 more source

Role of aliskiren in cardio-renal protection and use in hypertensives with multiple risk factors

Vascular Health and Risk Management, 2009
Eduardo Pimenta1, Suzanne Oparil21Endocrine Hypertension Research Center and Clinical Center of Research Excellence in Cardiovascular Disease and Metabolic Disorders, University of Queensland School of Medicine, Princess Alexandra Hospital, Brisbane, QLD,
Eduardo Pimenta, Suzanne Oparil
doaj   +2 more sources

Left atrial function in uraemic patients: Four‐dimensional automatic left atrial quantitative technology study

ESC Heart Failure, Volume 12, Issue 2, Page 1316-1325, April 2025.
Abstract Objective This study aimed to evaluate the utility of left atrial volume and function in uraemic patients using four‐dimensional automatic left atrial quantification (4D auto LAQ) technology. Methods Thirty‐four undialysed uraemic patients (U‐ND group), 60 dialysed uraemic patients (U‐D group), and 32 healthy volunteers (N group) were enrolled
Bing Li, Meihua Chen, Xuning Huang
wiley   +1 more source

Efficacy of Direct Renin Inhibitors in Slowing Down the Progression of Diabetic Kidney Disease: A Meta-Analysis. [PDF]

Cureus, 2022
Akbariromani H, Haseeb R, Nazly S, Pandey S, Anirudh Chunchu V, Dhakal S, Claudine Avena MA, Ali N.   +7 more
europepmc   +1 more source

Predictive Modeling of Phenylpiperazine Derivatives for Renin Inhibition: QSAR Study of Phenylpiperazine Derivatives as Renin Inhibitors

, 2018
The renin–angiotensin–aldosterone system is the well-established endocrine system having significant role in preserving hemodynamic stability. Renin is secreted from the juxtaglomerular cells of the kidney. Phenylpiperazine derivatives have been reported
Patel, Jimish R, Prajapati, Laxman M
core   +1 more source

Systematic review of the role of renin-angiotensin system inhibitors in late studies on Covid-19. A new challenge overcome?

, 2020
A role for the renin-angiotensin-aldosterone-system in Severe Acute Respiratory Syndrome-Coronavirus-2 infection and in the development of COronaVIrus Disease-19 disease has generated remarkable concerns among physicians and patients.
Battistoni, Allegra, Volpe, Massimo
core   +1 more source

Prognostic impact of iron deficiency in new‐onset chronic heart failure: Danish Heart Failure Registry insights

ESC Heart Failure, Volume 12, Issue 2, Page 1346-1357, April 2025.
Abstract Aims Iron deficiency (ID) is prevalent in chronic heart failure (HF) but lacks a consensus definition. This study evaluates the prevalence and the prognostic impact of ID using different criteria on all‐cause and cardiovascular mortality, as well as first hospitalization for HF in patients with new‐onset chronic HF.
Abdullahi Ahmed Mohamed, Daniel Mølager Christensen, Milan Mohammad, Christian Torp‐Pedersen, Lars Køber, Emil Loldrup Fosbøl, Tor Biering‐Sørensen, Morten Lock Hansen, Mariam Elmegaard Malik, Nina Nouhravesh, Charlotte Anderrson, Morten Schou, Gunnar Gislason   +12 more
wiley   +1 more source

Regulation of the renin–angiotensin system in coronary atherosclerosis: A review of the literature

Vascular Health and Risk Management, 2008
Ramadan A Hammoud, Christopher S Vaccari, Sameer H Nagamia, Bobby V KhanEmory University School of Medicine, Division of Cardiology, Grady Memorial Hospital Vascular Research Laboratory, Atlanta, Georgia, USAAbstract: Activation of the renin&ndash ...
Ramadan A Hammoud, Christopher S Vaccari, Sameer H Nagamia, Bobby V Khan   +3 more
doaj  

Discovery of Novel 2-Carbamoyl Morpholine Derivatives as Highly Potent and Orally Active Direct Renin Inhibitors. [PDF]

ACS Med Chem Lett, 2022
Iijima D, Sugama H, Awai N, Takahashi Y, Togashi Y, Takebe T, Xie J, Shen J, Ke Y, Akatsuka H, Kawaguchi T, Takedomi K, Kashima A, Nishio M, Inui Y, Yoneda H, Xia G, Iijima T.   +17 more
europepmc   +1 more source