Secreted Frizzled-Related Protein 1 Promotes Odontoblastic Differentiation and Reparative Dentin Formation in Dental Pulp Cells [PDF]
Cells, 2021 Direct pulp capping is an effective treatment for preserving dental pulp against carious or traumatic pulp exposure via the formation of protective reparative dentin by odontoblast-like cells.
Aoi Nozu +2 more
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Involvement of M1/M2 Macrophage Polarization in Reparative Dentin Formation [PDF]
Life, 2022 In cases in which dental pulp tissue is accidentally exposed, direct pulp capping is often performed to induce reparative dentin formation. Although macrophages are essential for the inflammatory response and tissue repair, the emergence pattern and the ...
Atsushi Tomokiyo +2 more
exaly +4 more sources
Dopamine is involved in reparative dentin formation through odontoblastic differentiation of dental pulp stem cells [PDF]
Scientific Reports, 2023 Conventional direct pulp-capping materials induce pulp cells to secrete various biomolecules in pulp tissues that promote reparative dentin formation through induction of odontoblastic differentiation of dental pulp stem cells (DPSCs).
Shoko Fujino +10 more
doaj +2 more sources
The role of complement C5a receptor in DPSC odontoblastic differentiation and in vivo reparative dentin formation [PDF]
International Journal of Oral Science, 2022 Therapeutic dentin regeneration remains difficult to achieve, and a majority of the attention has been given to anabolic strategies to promote dentinogenesis directly, whereas, the available literature is insufficient to understand the role of ...
Muhammad Irfan +6 more
doaj +2 more sources
Reparative dentin formation as a possible factor influencing the penetrability of dentin in human teeth with apical periodontitis: an ex vivo study [PDF]
BMC Oral Health, 2023 Background There is still a lack of knowledge regarding the permeability and configuration of infected root dentin. The aim of this ex vivo study was to compare the dentin penetrability of healthy teeth and necrotic teeth with apical periodontitis by ...
Yueyue Ren +4 more
doaj +2 more sources
Thiamet-G facilitates reparative dentin formation via modulating O-GlcNAcylation and inflammation [PDF]
Frontiers in PhysiologyIntroductionO-GlcNAcylation, a reversible post-translational modification regulated by O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA), is involved in various cellular processes, such as proliferation, differentiation, and inflammation modulation ...
Elina Pokharel +17 more
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Effect of calcium hydroxide and adipose-derived stem cell conditioned medium (ADSCs-CM) combination on reparative dentin formation in Wistar rats through RUNX-2 and OPN expression [PDF]
Journal of Oral Biology and Craniofacial ResearchBackground: Vital pulp exposure requires effective pulp capping to preserve the vitality and function of the dental pulp. Calcium hydroxide (Ca(OH)2) is widely used as a pulp capping agent; however, it has significant limitations, including the formation
Radixtio Auzan Fepiosandi +4 more
doaj +2 more sources
Spondin-1 Inhibits Odontoblastic Differentiation of Human Dental Pulp Stem Cells [PDF]
BiomoleculesReparative dentin formation is a defensive response that restores a mineralized barrier to protect the dental pulp following various stimuli, such as bacterial invasion, tooth preparation, or restorative materials.
Bara Mardini +9 more
doaj +2 more sources
Induction of Reparative Dentin by Calcium Silicate-Based Material as Direct Pulp Capping Agent
Bangabandhu Sheikh Mujib Medical University Journal, 2019 This study was performed to examine whether calcium silicate could induce reparative dentin formation without eliciting any adverse effect in direct pulp capping of premolar teeth.
Mozammal Hossain
exaly +3 more sources
Wnt/β-Catenin Pathway and Hydraulic Calcium Silicate-Based Cements: A Narrative Review [PDF]
Dentistry JournalThe Wnt/β-catenin signaling pathway regulates key cellular processes, including proliferation, migration, differentiation, apoptosis and tissue homeostasis, and plays a pivotal role in tooth development and post-developmental dental physiology.
Carmela Del Giudice +6 more
doaj +2 more sources