The Odontoblastic Differentiation of Dental Mesenchymal Stem Cells: Molecular Regulation Mechanism and Related Genetic Syndromes [PDF]
Frontiers in Cell and Developmental Biology, 2023 Dental mesenchymal stem cells (DMSCs) are multipotent progenitor cells that can differentiate into multiple lineages including odontoblasts, osteoblasts, chondrocytes, neural cells, myocytes, cardiomyocytes, adipocytes, endothelial cells, melanocytes ...
Yanfei Zhu, Houwen Pan
exaly +4 more sources
LncKCNQ1OT1 Promotes the Odontoblastic Differentiation of Dental Pulp Stem Cells via Regulating Hsa-miR-153-3p/RUNX2 Axis [PDF]
Cells, 2022 This study aimed to explore the role of LncKCNQ1OT1/hsa-miR-153-3p/RUNX2 in the odontoblastic differentiation of human dental pulp stem cells (DPSCs) and its possible mechanism.
Xingmei Feng, Guijuan Feng, Min Lian
exaly +4 more sources
RORα Regulates Odontoblastic Differentiation and Mediates the Pro-Odontogenic Effect of Melatonin on Dental Papilla Cells [PDF]
Molecules, 2021 Dental papilla cells (DPCs), precursors of odontoblasts, are considered promising seed cells for tissue engineering. Emerging evidence suggests that melatonin promotes odontoblastic differentiation of DPCs and affects tooth development, although the ...
Hongwen He, Jun Kang, Fuping Zhang
exaly +4 more sources
Dopamine is involved in reparative dentin formation through odontoblastic differentiation of dental pulp stem cells [PDF]
Scientific Reports, 2023 Conventional direct pulp-capping materials induce pulp cells to secrete various biomolecules in pulp tissues that promote reparative dentin formation through induction of odontoblastic differentiation of dental pulp stem cells (DPSCs).
Shoko Fujino +10 more
doaj +2 more sources
TAS2R supports odontoblastic differentiation of human dental pulp stem cells in the inflammatory microenvironment [PDF]
Stem Cell Research & Therapy, 2022 Background Inflammatory microenvironment promotes odontoblastic differentiation in human dental pulp stem cells (hDPSCs), but the regulatory mechanisms remain unclear.
Wen Kang +7 more
doaj +2 more sources
Spondin-1 Inhibits Odontoblastic Differentiation of Human Dental Pulp Stem Cells [PDF]
BiomoleculesReparative dentin formation is a defensive response that restores a mineralized barrier to protect the dental pulp following various stimuli, such as bacterial invasion, tooth preparation, or restorative materials.
Bara Mardini +9 more
doaj +2 more sources
Enamel Matrix Derivative Enhances the Odontoblastic Differentiation of Dental Pulp Stem Cells via Activating MAPK Signaling Pathways [PDF]
Stem Cells International, 2022 The odontoblastic differentiation of dental pulp stem cells (DPSCs) contributes to pulp-dentin regeneration. Enamel matrix derivative (EMD) is considered to be a critical epithelial signal to induce cell differentiation during odontogenesis and has been ...
Beidi Zhang +6 more
doaj +2 more sources
Odontoblasts release exosomes to regulate the odontoblastic differentiation of dental pulp stem cells [PDF]
Stem Cell Research & Therapy, 2023 Background Dental pulp stem cells (DPSCs) play a crucial role in dentin-pulp complex regeneration. Further understanding of the mechanism by which DPSCs remain in a quiescent state could contribute to improvements in the dentin-pulp complex and ...
Xinghong Luo +11 more
doaj +2 more sources
Metformin carbon nanodots promote odontoblastic differentiation of dental pulp stem cells by pathway of autophagy [PDF]
Frontiers in Bioengineering and Biotechnology, 2022 Human dental pulp stem cells (hDPSCs) have been a focus of pulp regeneration research because of their excellent odontogenic potential and availability.
Jinjin Lu +9 more
doaj +2 more sources
BACH1 regulates the proliferation and odontoblastic differentiation of human dental pulp stem cells [PDF]
BMC Oral Health, 2022 Background The preservation of biological and physiological vitality as well as the formation of dentin are among the main tasks of human dental pulp for a life time.
C. Liu +6 more
doaj +2 more sources