Results 11 to 20 of about 858,764 (131)

Neu5Ac Induces Human Dental Pulp Stem Cell Osteo-/Odontoblastic Differentiation by Enhancing MAPK/ERK Pathway Activation [PDF]

Stem Cells International, 2021
Dental pulp stem cells (DPSCs) must undergo odontoblastic differentiation in order to facilitate the process of dentin-pulp complex repair. Herein, we sought to explore the ability of Neu5Ac (one form of sialic acid) to influence DPSC osteo ...
Changzhou Li, Xinghuan Xie, Zhongjun Liu, Jianhua Yang, Daming Zuo, Shuaimei Xu   +5 more
doaj   +3 more sources

3D Spheroid Formation Using BMP-Loaded Microparticles Enhances Odontoblastic Differentiation of Human Dental Pulp Stem Cells [PDF]

Stem Cells International, 2021
Human dental pulp stem cells (hDPSCs) are the primary cells responsible for dentin regeneration. Typically, in order to allow for odontoblastic differentiation, hDPSCs are cultured over weeks with differentiation-inducing factors in a typical monolayered
Tae-Jun Min, Min Ji Kim, Kyung-Jung Kang, Yeoung Jo Jeoung, Se Heang Oh, Young-Joo Jang   +5 more
doaj   +3 more sources

BDNF/TrkB Is a Crucial Regulator in the Inflammation-Mediated Odontoblastic Differentiation of Dental Pulp Stem Cells [PDF]

Cells, 2023
The odontoblastic differentiation of dental pulp stem cells (DPSCs) associated with caries injury happens in an inflammatory context. We recently demonstrated that there is a link between inflammation and dental tissue regeneration, identified via ...
Ji-Hyun Kim, Muhammad Irfan, Md Akil Hossain, Anne George, Seung Chung   +4 more
doaj   +3 more sources

CREB3L1 deficiency impairs odontoblastic differentiation and molar dentin deposition partially through the TMEM30B [PDF]

International Journal of Oral Science
Odontoblasts are primarily responsible for synthesizing and secreting extracellular matrix proteins, which are crucial for dentinogenesis. Our previous single-cell profile and RNAscope for odontoblast lineage revealed that cyclic adenosine monophosphate ...
Yuanyuan Li, Yuxiu Lin, Jinqiang Guo, Delan Huang, Huanyan Zuo, Hanshu Zhang, Guohua Yuan, Huan Liu, Zhi Chen   +8 more
doaj   +3 more sources

Epithelium-derived SCUBE3 promotes polarized odontoblastic differentiation of dental mesenchymal stem cells and pulp regeneration [PDF]

Stem Cell Research & Therapy, 2023
Background Signal peptide-CUB-EGF domain-containing protein 3 (SCUBE3), a secreted multifunctional glycoprotein whose transcript expression is restricted to the tooth germ epithelium during the development of embryonic mouse teeth, has been demonstrated ...
Zijie Wang, Chuying Chen, Jiayi Zhang, Jiangdie He, Lin Zhang, Jiayuan Wu, Zhihui Tian   +6 more
doaj   +3 more sources

Inactivation of PI3K/Akt promotes the odontoblastic differentiation and suppresses the stemness with autophagic flux in dental pulp cells [PDF]

Journal of Dental Sciences, 2022
Background/purpose: Autophagy is involved in controlling differentiation of various cell types. The present study aimed to investigate the mechanism related to autophagy in regulating odontogenic differentiation of dental pulp cells.
Sam Young Park, Heui Seung Cho, Kyung Hwun Chung, Bin Na Lee, Sun Hun Kim, Won Jae Kim, Ji Yeon Jung   +6 more
doaj   +3 more sources

Chromatin Remodeller BRD9 Orchestrates Odontoblastic Differentiation via Coordinating RUNX2-KLF4. [PDF]

Cell Prolif
During odontoblast lineage commitment, the chromatin remodeller BRD9 acts as a critical epigenetic coordinator, orchestrating the chromatin landscape to facilitate synergistic binding of key transcription factors RUNX2 and KLF4 to target loci for odontogenesis.
Zeng W, Lin Y, Gao Y, Huang D, Li Y, Ruan H, Yuan G, Liu H, Chen Z.   +8 more
europepmc   +3 more sources

β-catenin enhances odontoblastic differentiation of dental pulp cells through activation of Runx2. [PDF]

PLoS ONE, 2014
An intense stimulus can cause death of odontoblasts and initiate odontoblastic differentiation of stem/progenitor cell populations of dental pulp cells (DPCs), which is followed by reparative dentin formation.
Nana Han, Yong Zheng, Ran Li, Xianyu Li, Mi Zhou, Yun Niu, Qi Zhang   +6 more
doaj   +2 more sources

Role of connexin 43 in odontoblastic differentiation and structural maintenance in pulp damage repair [PDF]

International Journal of Oral Science, 2021
Dental pulp can initiate its damage repair after an injury of the pulp–dentin complex by rearrangement of odontoblasts and formation of newly differentiated odontoblast-like cells.
Jiaxin Yin, Jue Xu, Ran Cheng, Meiying Shao, Yuandong Qin, Hui Yang, Tao Hu   +6 more
doaj   +2 more sources

GSK3β rephosphorylation rescues ALPL deficiency-induced impairment of odontoblastic differentiation of DPSCs [PDF]

Stem Cell Research & Therapy, 2021
Background Premature exfoliation of the deciduous teeth is a common manifestation in childhood patients with hypophosphatasia (HPP), which is an autosomal inherited disease caused by ALPL mutations.
Liqiang Zhang, Jiangdong Zhao, Jiayi Dong, Yuting Liu, Kun Xuan, Wenjia Liu   +5 more
doaj   +2 more sources