Results 71 to 80 of about 861,022 (290)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

EFFECT OF LAP SPLICING HIGH TENSILE STEEL BARS IN REACTIVE POWDER CONCRETE BEAMS EXPOSED TO REPEATED LOADING

Journal of Engineering and Sustainable Development, 2017
This research is an experimental study to evaluate the effect of lap splice of high-strength steel bars in reactive powder concrete beams exposed to repeated loading.
Hisham M Al-Hassani, Qais Abdul Majeed Hassan, Faten Fadhil Saleem   +2 more
doaj  

Experimental and modelling buckling of wood-based columns under repeated loading

EPJ Web of Conferences, 2010
Collapse of timber constructions can appear under the effect of load that exceeds the resistance of a carrying element or under the effect of a geometrical instability like buckling.
Nafa Z., Chaplain M., Bouras F.
doaj   +1 more source

Поліпшення пластичних властивостей високоміцних двофазних титанових сплавів за рахунок ударно-коливального навантаження [PDF]

, 2017
It is established experimentally that dynamic non-equilibrium processes (DNP) with self-organizing structure occur under impact-oscillatory loading in high-strength two-phase titanium alloys VT22 and VT23.
Марущак, Павло Орестович, Пилипенко, Андрій Петрович, Чаусов, Микола Георгійович   +2 more
core  

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Experimental Research on Breakage Characteristics of Feed Pellets under Different Loading Methods

Agriculture
Particle breakage is a common phenomenon during the processes of production, storage, and transportation. Because of the requirements for pellet integrity in poultry farming, research on the breakage characteristics of feed pellets is necessary.
Xianrui Kong, Qing Cao, Zhiyou Niu
doaj   +1 more source

Repeated drop-weight impact tests on self-compacting concrete reinforced with micro-steel fiber

Heliyon, 2020
Steel fiber has become a proven material that can significantly alter the behavior of different types of concrete mixtures from brittle to more ductile ones.
Sallal R. Abid, Munther L. Abdul-Hussein, Nadheer S. Ayoob, Sajjad H. Ali, Ahmed L. Kadhum   +4 more
doaj   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Finite Element Analysis of Voided Reinforced Concrete Slabs Enhanced by GFRP Sheets under Monotonic and Repeated Loads

Journal of Engineering
Six (1000*1000 mm2) slab specimens were cast and tested as two-way simply supported slabs previously (three under monotonic loading and three under repeated loading) are used in this research.
Shahad H. Mtashar, Adel A. Al-Azzawi
doaj   +1 more source

One-dimensional compression of a crushable sand in dry and wet conditions [PDF]

, 2015
This paper presents the results of a series of dry and wet one-dimenional compression tests on a calcareous sand from the Persian Gulf. Calcareous grains crush more easily compared to silica grains, a fact that is mainly attributed to their angular shape
Haegeman, Wim, Van Impe, Peter, Wils, Laure   +2 more
core   +1 more source