Results 121 to 130 of about 382,913 (294)

Lesões de isquemia e reperfusão no intestino de eqüinos: fisiopatologia e terapêutica Intestinal ischemia-reperfusion injury in horses: pathophysiology and therapeutics

Ciência Rural, 2000
O abdome agudo constitui a principal causa de óbito em eqüinos, sendo que dentre as suas etiologias são freqüentes as afecções acompanhadas de isquemia e reperfusão (IR) no intestino.
Jorge José Rio Tinto de Matos, Geraldo Eleno Silveira Alves, Rafael Resende Faleiros, Antônio de Pinho Marques Júnior   +3 more
doaj   +1 more source

Myocardial infarct-sparing effect of ischemic preconditioning abrogated in cirrhotic rat through involvement of mitochondrial permeability transition pore [PDF]

, 2012
Despite all studies undertaken mechanism of cirrhotic cardiomyopathy the role of cirrhosis on ischemia-reperfusion (I/R) injury and ischemic preconditioning (IPC) phenomenon hasn't been explored yet.
Dehpour, A.R., Jafrazedeh, F., Khori, V., Mohimani, H.R., Mohsen, N.   +4 more
core  

Reduction of myocardial infarction by calpain inhibitors A-705239 and A-705253 in isolated perfused rabbit hearts [PDF]

, 2004
Two novel calpain inhibitors (A-705239 and A-705253) were studied in isolated perfused rabbit hearts subjected to 60-min occlusion of the ramus interventricularis of the left coronary artery (below the origin of the first diagonal branch), followed by ...
Deibele, Karin, Fabiunke, Verena, Fritz, Hans, Lubisch, Wilfried, Möller, Achim, Neuhof, Christiane, Neuhof, Heinz, Speth, Maria, Tillmanns, Harald   +8 more
core   +1 more source

PAF Triggered Pyroptotic NETosis Aggravates Myocardial Ischemia/Reperfusion Injury

Advanced Science, EarlyView.
Platelet activating factor (PAF) secreted by cardiomyocytes during MI/R, drives NETs formation and subsequent NETosis. PAF/NETosis signaling activation is an initiative and causal factor in driving MI/R injury. This study identifies dapagliflozin as a potent NETosis inhibitor, and demonstrates that manipulating PAF‐NETosis signal by dapagliflozin or ...
Jiawei Wu, Shule Zhang, Ruofan Du, Lina Kang, Guodong Zhao, Xue Bao, Haochi Yang, Ziqing Xie, Tianyu He, Huiyong Sun, Haiping Hao, Lijuan Cao   +11 more
wiley   +1 more source

Danshensu for Myocardial Ischemic Injury: Preclinical Evidence and Novel Methodology of Quality Assessment Tool

Frontiers in Pharmacology, 2018
Background: Danshensu (DSS) possesses unique bioactivity on the cardiovascular system. However, there is a lack of systematical summary of DSS for acute myocardial ischemia injury and no quality assessment tool for the systematical review of cell ...
Xiao-yi Bao, Qun Zheng, Qiang Tong, Peng-chong Zhu, Zhuang Zhuang, Guo-qing Zheng, Yan Wang   +6 more
doaj   +1 more source

Decoding the Cardiac Immune Microenvironment and Fibroblast Crosstalk in Radiotherapy Combined with Immunotherapy‐Induced Cardiac Fibrosis Based on Single‐Cell Transcriptomic Analysis

Advanced Science, EarlyView.
This study highlights that radioimmunotherapy drives crosstalk between fibroblasts and immune cells (especially macrophages) in the cardiac microenvironment, with IL‐6 as the key mediator, and tocilizumab alleviates cardiac fibrosis by targeting this interplay.
Yuxi Luo, Ying Yu, Zhimin Zeng, Yanxin Chen, Yali Yi, Zhiqin Lu, Fujuan Zeng, Peng Xu, Daya Luo, Leifeng Chen, Anwen Liu   +10 more
wiley   +1 more source

Emergency Ultra-Deep Hypothermia in Cardiac Arrest Induced by Blood Loss (Experimental Study on Nonhuman Primates)

Общая реаниматология
The survival rate of critically injured individuals with severe blood loss and cardiac arrest is close to zero.Aim. To evaluate the feasibility of using emergency ultra-deep hypothermia (EUDH) in an experimental model of cardiac arrest induced by blood ...
Victor A. Reva, Anastasia R. Samakaeva, Daniil A. Shelukhin, Sergey V. Orlov, Vladimir D. Potemkin, Dmitry V. Bulgin, Galina Y. Gracheva, Alexey V. Shchegolev   +7 more
doaj   +1 more source

An Observational study of prehospital and hospital delay in reperfusion for acute myocardial infarction at a University Hospital in India

Journal of the Practice of Cardiovascular Sciences, 2016
Objective: Cardiovascular disease is the leading cause of death among Indian adults, and approximately 50% of deaths usually occur during the 1st hour after symptom onset before arriving at the hospital.
Rahul Choudhary, Shashi Mohan Sharma, Vimla Kumar, Dinesh Kumar Gautam   +3 more
doaj   +1 more source

Elevated TRIM25 Impairs Poly (ADP‐ribose) Metabolism via PARG Degradation and Mediates Compression‐Induced Intervertebral Disc Degeneration

Advanced Science, EarlyView.
TRIM25 acts as a multifunctional hub driving intervertebral disc degeneration under mechanical stress. Mechanical compression significantly upregulates TRIM25 expression, establishing it as a key E3 ubiquitin ligase platform. TRIM25 targets PARG and Ku80 via distinct molecular interfaces, triggering their ubiquitination and degradation.
Zhangrong Cheng, Haiyang Gao, Wenbo Wu, Pengzhi Shi, Xianglong Chen, Zimu Yu, Wang Wu, Kangcheng Zhao, Cao Yang, Yukun Zhang   +9 more
wiley   +1 more source

Author Correction: Human macrophages differentially produce specific resolvin or leukotriene signals that depend on bacterial pathogenicity

Nature Communications, 2023
Oliver Werz, Jana Gerstmeier, Stephania Libreros, Xavier De la Rosa, Markus Werner, Paul C. Norris, Nan Chiang, Charles N. Serhan   +7 more
doaj   +1 more source