Results 121 to 130 of about 432,839 (343)
Advanced Science, EarlyView.Stroke‐induced lactate accumulation promotes p300‐mediated lactylation of methyl‐CpG binding protein 2 (MeCP2) at lysine 210, which reprograms microglial metabolism toward glycolysis and activates the hexokinase 2 (HK2)/mTOR axis. This cascade promotes proinflammatory responses and impairs neurofunctional outcomes.
Zengyu Zhang +12 more
wiley +1 more source
Advanced Science, EarlyView.MC‐LR stabilizes DNMT1/3a by blocking their ubiquitin‐mediated degradation, leading to Gpx4 promoter hypermethylation and E2F4/NCoR‐associated transcriptional repression, which drives renal tubular ferroptosis in mice. Pharmacological inhibition of DNA methylation (SGI‐1027) or ferroptosis (Fer‐1) disrupts this DNMT‐GPX4 axis, thereby alleviating MC‐LR‐
Shaoru Zhang +12 more
wiley +1 more source
Heart rate variability dynamics in acute phase of myocardial infarction
Российский кардиологический журнал, 2007 Heart rate variability (HRV) dynamics was assessed in the first 24 hours of acute myocardial infarction (AMI). HRV parameters (SDNN, rMSSD, pNN50) were linked to various post-thrombolysis AMI clinical variants.
V. A. Lusov +5 more
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Advanced Science, EarlyView.Our research reveals that small‐molecule icariin (ICA) directly binds Ras‐GTPase‐activating protein SH3 domain‐binding protein 1 (G3BP1), inducing conformational change and oligomerization. This interaction confers neuroprotection by recruiting insulin‐like growth factor 2 mRNA‐binding protein 1 (IGF2BP1) and modulating N6‐methyladenosine (m6A ...
Ling Li +17 more
wiley +1 more source
THE INFLUENCE OF AMINO ACIDS DERIVATIVES ON REPERFUSION ARRHYTHMIAS
Российский кардиологический журнал, 2003 Preventive antiarrhythmic properties of lidocaine and six new combinations of amino acids with microelements. In models of reperfusion arrhythmias in cats all study drugs more or less prevented post-reperfusion arrhythmias including fatal ventricular ...
E. E. Yalayava +2 more
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The Role of Reactive Oxygen Species in Contractile Dysfunction Following Ischemia/Reperfusion [PDF]
, 2011 Laura D. Gauthier +2 more
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Advanced Science, EarlyView.This study shows that integrin receptor CD49a (Itga1 gene) is significantly upregulated in hyperactivated microglia and microglia‐specific knockdown of Itga1 rescues neuroinflammation and neurodegeneration in a chronic Parkinson's disease (PD) model by targeting PGAM5‐mediated mitochondrial dysfunction and NLRP3 activation. Targeted inhibition of CD49a
Huanpeng Lu +6 more
wiley +1 more source
卒中：回眸2024 Highlights in Stroke in 2024
Zhongguo cuzhong zazhi摘要： 2024年，脑血管病临床研究进展显著。全球卒中领域研究者们共同的智慧和努力进一步完善了脑血管病的诊疗和管理策略。在出血性卒中领域，特别是在硬膜下血肿和原发性脑出血的治疗方面，研究取得了令人振奋的突破性进展。同时，缺血性卒中作为近年来的研究热点，在静脉溶栓、动脉取栓和二级预防等多个方面，不断涌现出更多高质量的研究成果，为临床诊疗提供了更多、更坚实的证据。本文将对2024年脑血管病领域的关键临床研究结果进行总结和解读，旨在帮助读者更好地把握当前的研究热点，深入理解其意义。 Abstract: In
熊云云1，2，3，4，李光硕1，马宇洁1，李祉馨1，沈柯佳1，马瑛1，孙大鹏1，孙溢阳1，王拥军1，2，3，5，6，7（XIONG Yunyun1,2,3,4, LI Guangshuo1, MA Yujie1, LI Zhixin1, SHEN Kejia1, MA Ying1, SUN Dapeng1, SUN Yiyang1, WANG Yongjun1,2,3,5,6,7 ）
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Advanced Science, EarlyView.This study identifies L‐type calcium channel blockers as novel ferroptosis inhibitors. It reveals that PKCβ, activated in calcium dependent manner, phosphorylates and activates ACSL4 and ALOX15, relocating them to lipid droplets to promote lethal lipid peroxidation and ferroptosis.
Guoyuan Hou +8 more
wiley +1 more source