Results 111 to 120 of about 468,820 (359)

Deletion of Cardiac miR-17-92 Cluster Increases Ischemia/ Reperfusion Injury via PTEN Upregulation [PDF]

, 2017
The miR-17- 92 cluster is necessary for cell proliferation and development of the cardiovascular system. Deletion of this cluster leads to death in neonatal mice.
Prakash, Meeta B
core   +1 more source

Intramyocardial hemorrhage: An enigma for cardiac MRI? [PDF]

, 2015
Cardiovascular magnetic resonance (CMR) is a useful noninvasive technique for determining the presence of microvascular obstruction (MVO) and intramyocardial hemorrhage (IMH), frequently occurring in patients after reperfused myocardial infarction (MI ...
Calvieri, Camilla, Fedele, F., Gualdi, G. F., Masselli, G., Monti, R., Spreca, M.   +5 more
core   +4 more sources

Epithelial TRIM27 Inhibits Intestinal Inflammation in Ulcerative Colitis by the USP7/TRIM27‐IKK Double Negative‐Feedback

Advanced Science, EarlyView.
ABSTRACT The E3 ubiquitin ligase tripartite motif 27 (TRIM27) is a negative regulator of NF‐κB activation and the innate immune response, and TRIM27 deficiency significantly impairs dextran sulfate sodium (DSS)‐induced colitis. The function of TRIM27 in intestinal epithelial cells (IECs), the mechanism by which TRIM27 inhibits the NF‐κB pathway and its
Weimin Xu, Zhebin Hua, Zhujiang Dai, Shasha Zhang, Yihan Jiang, Wensong Ge, YingWei Chen, Zhongchuan Wang, Bing Zhang, Chen‐Ying Liu, Peng Du   +10 more
wiley   +1 more source

Purine nucleoside phosphorylase: A new marker for free oxygen radical injury to the endothelial cell [PDF]

, 1990
The effect of ischemia and reperfusion on purine nucleoside phosphorylase was studied in an isolated perfused rat liver model. This enzyme is localized primarily in the cytoplasm of the endothelial and Kupffer cells; some activity is associated with the ...
Abouna, Adkison, Eiseman, Granger, Green, Hanks, Hoffee, James T. Snyder, Kamada, Kamiike, Kamiike, Kizaki, Lanir, Lee, Lee, LeMasters, LeMasters, Leonard Makowka, Marotto, Marubayashi, Marubayashi, McCord, Nishida, Parks, Prakash N. Rao, Randy S. Rubin, Rubio, Teperman, Thomas E. Starzl, Thomas R. Walsh, Thomas Weber, Turner, Van Thiel   +32 more
core   +1 more source

POU2F1 Promotes Chemoresistance in Colorectal Cancer Cells via Attenuates the MDR2 Degradation Mediated by PPP1R11 Lactylation

Advanced Science, EarlyView.
Schematic diagram of our study showing that highly expressed POU2F1 in colorectal cancer (CRC) can directly accelerate the cytosolic lactate export to decrease PPP1R11 lactylation at K59, thereby attenuating the E3 ligase enzyme activity and protein stability of PPP1R11, which inhibits the ubiquitination of MDR2 at K413 and K538 but increases the ...
Longzheng Xia, Jinguan Lin, Xianjie Jiang, Linda Oyang, Shiming Tan, Zongyao Ren, Qiu Peng, Qianjin Liao, Yujuan Zhou   +8 more
wiley   +1 more source

SiO2 nanoparticles as disruptors of endogenous resolution mechanisms of inflammatory responses that exacerbate pneumonia

Scientific Reports
Occupational exposure to engineered nanomaterials (ENMs) is increasing in the workplace and can impact human health. Amorphous silicon dioxide nanoparticles (SiO2 NPs) are widely produced respirable ENMs used in commercial products.
Luciana Pádua Tavares, Stephania Libreros, Dimitrios Bitounis, Robert Nshimiyimana, Philip Demokritou, Charles N. Serhan, Bruce D. Levy   +6 more
doaj   +1 more source

从起步到辉煌——中国卒中临床研究发展20年 From Inception to Excellence: Two Decades of Stroke Clinical Research in China

Zhongguo cuzhong zazhi
卒中是造成我国居民残疾和死亡的主要疾病之一，给医疗系统带来了巨大负担。循证医学研究为卒中诊疗提供了可靠的数据指导，显著降低了卒中的残疾率与死亡率。近20年来，中国临床工作者和科研人员围绕卒中诊疗的各个环节，在急性缺血性卒中再灌注治疗、卒中二级预防、脑细胞保护、血管内治疗围手术期管理、卒中诊疗质量控制与管理等重要及热点领域贡献了诸多宝贵的循证医学证据，在卒中临床研究领域发挥着越来越重要的作用。本文简要回顾了我国卒中循证医学研究的发展历程，概述了中国研究者在卒中诊疗循证实践方面的贡献与成就 ...
熊云云1，王拥军1，2（XIONG Yunyun1, WANG Yongjun1,2 ）
doaj   +1 more source

Assessment of myocardial ischemia with proton magnetic resonance: effects of a three hour coronary occlusion with and without reperfusion. [PDF]

, 1985
Donald L. Johnston, Thomas J. Brady, A V Ratner, Boaz Rosen, John Newell, Gerald M. Pohost, Robert D. Okada   +6 more
openalex   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Lesões de isquemia e reperfusão no intestino de eqüinos: fisiopatologia e terapêutica Intestinal ischemia-reperfusion injury in horses: pathophysiology and therapeutics

Ciência Rural, 2000
O abdome agudo constitui a principal causa de óbito em eqüinos, sendo que dentre as suas etiologias são freqüentes as afecções acompanhadas de isquemia e reperfusão (IR) no intestino.
Jorge José Rio Tinto de Matos, Geraldo Eleno Silveira Alves, Rafael Resende Faleiros, Antônio de Pinho Marques Júnior   +3 more
doaj   +1 more source