Results 61 to 70 of about 432,839 (343)

FeDSNP‐Pa Nanoassemblies: A Triple‐Action Therapeutic Strategy Targeting Oxidative Stress, Inflammation, and Pyroptosis for Retinal Ganglion Cell Protection in Glaucoma

Advanced Functional Materials, EarlyView.
FeDSNP‐Pa, a metallized nanoparticle loaded with sodium pyruvate (Pa), exerts triple therapeutic effects by scavenging reactive oxygen species (ROS), suppressing inflammatory responses, and inhibiting pyroptosis signaling pathways. This multifunctional neuroprotective strategy protecting retinal ganglion cells (RGCs) from elevated intraocular pressure ...
Yukun Wu, Xue Li, Tong Wu, Dan Ji, Yugang Bai, Xuezhi Zhou   +5 more
wiley   +1 more source

CD4+CD25+FOXP3+ regulatory T cells: a potential “armor” to shield “transplanted allografts” in the war against ischemia reperfusion injury

Frontiers in Immunology, 2023
Despite the advances in therapeutic interventions, solid organ transplantation (SOT) remains the “gold standard” treatment for patients with end-stage organ failure.
Shareni Jeyamogan, Joseph R. Leventhal, Joseph R. Leventhal, James M. Mathew, James M. Mathew, James M. Mathew, Zheng Jenny Zhang, Zheng Jenny Zhang, Zheng Jenny Zhang   +8 more
doaj   +1 more source

Drug‐Free Thrombolysis Mediated by Physically Activated Micro/Nanoparticles

Advanced Functional Materials, EarlyView.
Overview of particle‐mediated thrombolytic effects (thermal, mechanical, and chemical) and their activating physical stimuli (light, ultrasound, and magnetic field) in drug‐free thrombolysis. ABSTRACT Thrombus‐associated disorders rank among the world's leading causes of death, with ischemic heart disease and stroke as the main contributors.
Pierre Sarfati, Yoann Lalatonne, Cédric Chauvierre   +2 more
wiley   +1 more source

Adenosine in Acute Myocardial Infarction-Associated Reperfusion Injury: Does it Still Have a Role?

Frontiers in Pharmacology, 2022
The mainstay of acute myocardial infarction has long been timely reperfusion of the culprit obstruction. Reperfusion injury resulting from a multitude of pathophysiological processes has been demonstrated to negatively affect myocardial recovery and ...
Corrado De Marco, Corrado De Marco, Thierry Charron, Thierry Charron, Guy Rousseau, Guy Rousseau   +5 more
doaj   +1 more source

Reperfusion Injury: How Can We Reduce It by Pre-, Per-, and Postconditioning [PDF]

, 2023
Maria Buske, Steffen Desch, Gerd Heusch, Tienush Rassaf, Ingo Eitel, Hölger Thiele, Hans‐Josef Feistritzer   +6 more
openalex   +1 more source

eTICI reperfusion: defining success in endovascular stroke therapy

Journal of NeuroInterventional Surgery, 2018
Background Revascularization after endovascular therapy for acute ischemic stroke is measured by the Thrombolysis In Cerebral Infarction (TICI) scale, yet variability exists in scale definitions.
D. Liebeskind, S. Bracard, F. Guillemin, R. Jahan, T. Jovin, C. Majoie, P. Mitchell, A. van der Lugt, B. Menon, L. San Román, B. Campbell, K. Muir, M. Hill, D. Dippel, J. Saver, A. Demchuk, A. Dávalos, P. White, Scott C. Brown, M. Goyal   +19 more
semanticscholar   +1 more source

Infusible Extracellular Matrix Biomaterial Enhances Cell‐Specific Pro‐Repair Responses Following Acute Myocardial Infarction

Advanced Healthcare Materials, EarlyView.
We measure the cell‐specific responses of administering infusible ECM (iECM) in acute myocardial infarction (MI) across multiple timepoints. Using single‐nucleus RNA sequencing and spatial transcriptomics, we measure macrophage activation, fibroblast remodeling, increased vascular development, lymphangiogenesis, cardioprotection, and neurogenesis ...
Joshua M. Mesfin, Alexander Chen, Quincy P. Lyons, Michael B. Nguyen, Maria L. Karkanitsa, Justin Yu, Van K. Ninh, Emily Gardner, Elyse G. Wong, Sriya N. Paleti, Julian Cheng, Benjamin D. Bridgelal, Kate E. Reimold, Selena Cao, Connor Uhre, Colin G. Luo, Zhenxing Fu, Kevin R. King, Karen L. Christman   +18 more
wiley   +1 more source

Gut microbiota-derived gamma-aminobutyric acid from metformin treatment reduces hepatic ischemia/reperfusion injury through inhibiting ferroptosis

eLife
Hepatic ischemia/reperfusion injury (HIRI) is a common and inevitable factor leading to poor prognosis in various liver diseases, making the outcomes of current treatments in clinic unsatisfactory.
Fangyan Wang, Xiujie Liu, Furong Huang, Yan Zhou, Xinyu Wang, Zhengyang Song, Sisi Wang, Xiaoting Wang, Dibang Shi, Gaoyi Ruan, Xiawei Ji, Eryao Zhang, Zenglin Tan, Yuqing Ye, Chuang Wang, Jesse Zhu, Wantie Wang   +16 more
doaj   +1 more source

Unloading the Left Ventricle Before Reperfusion in Patients With Anterior ST-Segment–Elevation Myocardial Infarction: A Pilot Study Using the Impella CP

Circulation, 2019
Background: In ST-segment–elevation myocardial infarction (STEMI), infarct size correlates directly with heart failure and mortality. Preclinical testing has shown that, in comparison with reperfusion alone, mechanically unloading the left ventricle (LV)
N. Kapur, M. A. Alkhouli, Tony Demartini, Haroon Faraz, Zachary George, M. Goodwin, J. Hernandez-Montfort, V. Iyer, N. Josephy, Sanjog Kalra, Amir Kaki, R. Karas, C. Kimmelstiel, Gerald Koenig, E. Lau, K. Lotun, R. Madder, S. Mannino, P. Meraj, J. Moreland, J. Moses, Raymond L. Kim, T. Schreiber, J. Udelson, C. Witzke, D. Wohns, W. O’Neill   +26 more
semanticscholar   +1 more source

Targeting the ARRDC3–DRP1 Axis via hUMSC‐Derived Exosomal CRYAB for Neuroprotection in Cerebral Ischemia/Reperfusion Injury

Advanced Healthcare Materials, EarlyView.
Intranasally administered hUMSC‐derived exosomes modulate the CRYAB–ARRDC3–Drp1 axis, alleviating mitochondrial dysfunction and ferroptosis, enhancing neuronal survival, reducing oxidative stress, and promoting functional recovery in ischemia‐reperfusion injury, offering a promising therapeutic strategy for ischemic stroke.
Rong ji, Zengyu Zhang, Zhuohang Liu, Kaicheng Yang, Xueyu Mao, Min Chu, Yong Wang, Jing Zhao   +7 more
wiley   +1 more source