Results 81 to 90 of about 267,492 (314)

Milrinone and levosimendan administered after reperfusion improve myocardial stunning in swine [PDF]

, 2013
Objectives. We assessed the effect of milrinone application timing after reperfusion against myocardial stunning as compared with levosimendan in swine. Furthermore, we examined the role of p38 mitogen-activated protein kinase (p38 MAPK) in the milrinone-
Cho, Sungsam, Maekawa, Takuji, Yoshitomi, Osamu, Hara, Tetsuya, Sumikawa, Koji, Shibata, Itsuko, Ureshino, Hiroyuki   +6 more
core   +1 more source

Dual‐Responsive Dynamic Covalent Bond‐Based Assembly of Lipid‐Nanozyme Systems via Multi‐Target Synergy and Efficient Target Enrichment for Ischemic Stroke Therapy

Advanced Science, EarlyView.
This system adopts a biomimetic phospholipid structure, covalently binding iNOS inhibitors, neuroprotective agent PCA and vitamin E derivatives through pH/ROS dual‐responsive bonds, and assembles them with Prussian blue nanozyme to form PBB@AHA. It can efficiently penetrate the blood‐brain barrier and simultaneously release multiple active components ...
Mengcheng Guo, Qingran Guan, Guanyu Qiao, Lixue Zhang, Man Liu, Zhen Li, Qingbiao Yang, Meili Shen, Linlin Liu, Yapeng Li   +9 more
wiley   +1 more source

Ischemic preconditioning prevents endothelial injury and systemic neutrophil activation during ischemia-reperfusion in humans in vivo

, 2001
Background-Endothelial dysfunction leading to neutrophil infiltration of tissues has been implicated in tissue injury caused by ischemia-reperfusion (IR). Tissue injury during IR can be reduced by prior ischemic preconditioning (IPC).
Kattenhorn, M, Peters, M, Mullen, M, Kharbanda, RK, Walton, B, Kharbanda, Rajesh, Vallance, P, Klein, N, MacAllister, R, Deanfield, J   +9 more
core   +1 more source

G3BP1 Succinylation at K413 is Critical for Cardiac Function by Modulating PI3K‐AKT‐mTOR Signal Axis

Advanced Science, EarlyView.
Schematic illustrating the impact of G3BP1 succinylation at K413 on cardiac function. In the healthy human heart, G3BP1 succinylation maintains homeostatic mTOR signaling. In patients with dilated cardiomyopathy (DCM) and heart failure (HF), G3BP1 de‐succinylation induces RagA expression and disrupts the binding of the TSC1/2 complex, leading to the ...
Yuan Zhang, Cancan Yao, Yan Chen, Ke Cai, Zhouping Lu, Boxuan Wu, Kun Yu, Yan Shi, Jianyuan Zhao, Xiangyu Zhou   +9 more
wiley   +1 more source

Gut microbiota-derived gamma-aminobutyric acid from metformin treatment reduces hepatic ischemia/reperfusion injury through inhibiting ferroptosis

eLife
Hepatic ischemia/reperfusion injury (HIRI) is a common and inevitable factor leading to poor prognosis in various liver diseases, making the outcomes of current treatments in clinic unsatisfactory.
Fangyan Wang, Xiujie Liu, Furong Huang, Yan Zhou, Xinyu Wang, Zhengyang Song, Sisi Wang, Xiaoting Wang, Dibang Shi, Gaoyi Ruan, Xiawei Ji, Eryao Zhang, Zenglin Tan, Yuqing Ye, Chuang Wang, Jesse Zhu, Wantie Wang   +16 more
doaj   +1 more source

Early Coronary Reperfusion Facilitates Return of Spontaneous Circulation and Improves Cardiovascular Outcomes After Ischemic Cardiac Arrest and Extracorporeal Resuscitation in Pigs

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016
Background Extracorporeal cardiopulmonary resuscitation (ECPR) is widely proposed for the treatment of refractory cardiac arrest. It should be associated with coronary angiography if coronary artery disease is suspected.
Alice Hutin, Lionel Lamhaut, Fanny Lidouren, Matthias Kohlhauer, Nicolas Mongardon, Pierre Carli, Alain Berdeaux, Bijan Ghaleh, Renaud Tissier   +8 more
doaj   +1 more source

Selective Inhibition of Integrin β3 Topology Provides a Safer Antithrombotic Strategy

Advanced Science, EarlyView.
Current integrin αIIbβ3 inhibitors effectively reduce thrombosis but also increase bleeding risk. During thrombosis, high shear blood flow can directly activate the integrin αIIbβ3 via a distinct topological change in the β3 transmembrane domain, independent of hemostatic platelet signaling.
Joonha Lee, Chul‐Gyun Lim, Pothiappan Vairaprakash, Jong‐Min Kim, Jiyoon Kim, Ji‐Young Park, Klaus M. Hahn, Hyunbo Shim, Hae Woong Choi, Tobias S. Ulmer, Soon Jun Hong, Chungho Kim   +11 more
wiley   +1 more source

Epithelial TRIM27 Inhibits Intestinal Inflammation in Ulcerative Colitis by the USP7/TRIM27‐IKK Double Negative‐Feedback

Advanced Science, EarlyView.
ABSTRACT The E3 ubiquitin ligase tripartite motif 27 (TRIM27) is a negative regulator of NF‐κB activation and the innate immune response, and TRIM27 deficiency significantly impairs dextran sulfate sodium (DSS)‐induced colitis. The function of TRIM27 in intestinal epithelial cells (IECs), the mechanism by which TRIM27 inhibits the NF‐κB pathway and its
Weimin Xu, Zhebin Hua, Zhujiang Dai, Shasha Zhang, Yihan Jiang, Wensong Ge, YingWei Chen, Zhongchuan Wang, Bing Zhang, Chen‐Ying Liu, Peng Du   +10 more
wiley   +1 more source

Evaluating the efficacy of smoke management technologies in laparoscopic sleeve gastrectomy: insights from a prospective, single-centre comparative study

Scientific Reports
Surgical power devices generate surgical smoke that may contain infectious components. Various technologies have been developed to improve surgical smoke management, but comparative performance data from human studies are limited.
Cédric R. D. Demtröder, Daniel Göhler, Kathrin Oelschlägel, Claudia Jahn-Wolf, Hülya Agarius, Peter Kirchmeyer, Fabian Kockelmann, Sébastien Roger, Mehdi Ouaissi, Dmitrij Dajchin, Urs Giger-Pabst   +10 more
doaj   +1 more source

Therapeutic modulation of liver ischaemia reperfusion injury

, 2011
Liver Ischaemia Reperfusion Injury (IRI) leads to production of reactive oxygen species and cytokines, which affects hepatocellular function following liver resection and transplantation.
Sheth, H.
core