Results 111 to 120 of about 2,176,828 (392)

Orphan targets for reperfusion injury [PDF]

Cardiovascular Research, 2009
Cardiomyocyte death secondary to transient ischaemia occurs mainly during the first minutes of reperfusion in the form of contraction band necrosis. Research on the mechanisms leading to sarcolemmal rupture and necrosis during initial reperfusion identified several promising pharmacological targets directed either to correct the alterations in Ca(2 ...
Javier Inserte, David Garcia-Dorado, Victor Hernando, José A. Barrabés   +3 more
openaire   +3 more sources

Transparent Temperature Sensors for Photothermal Neuromodulation: Advances, Challenges, and Future Directions

Advanced Materials Interfaces, EarlyView.
Photothermal neuromodulation is a promising technique for versatile neural signal study and treatment development. To further develop these technologies and optimize their effectiveness, transparent electrical temperature sensors with high thermal sensitivity and resolution are essential for accurately monitoring temperature changes during ...
Jee Woong Lee, Junhee Lee, Jungha Lee, Duhee Kim, Woongki Hong, Junghyup Lee, Minyoung Song, Hongki Kang   +7 more
wiley   +1 more source

Unmet goals in the treatment of Acute Myocardial Infarction: Review [version 1; referees: 2 approved]

F1000Research, 2017
Reperfusion therapy decreases myocardium damage during an acute coronary event and consequently mortality. However, there are unmet needs in the treatment of acute myocardial infarction, consequently mortality and heart failure continue to occur in about
Alejandro Farah, Alejandro Barbagelata
doaj   +1 more source

Clinical expression of plakophilin-2 mutations in familial arrhythmogenic right ventricular cardiomyopathy [PDF]

, 2006
Background - Arrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited cardiac disorder characterized by loss of cardiomyocytes and their replacement by adipose and fibrous tissue.
Asimaki, A, Ebrahim, HY, Elliott, PM, Evans, A, Hitomi, N, McKenna, WJ, Norman, M, Pantazis, A, Sen-Chowdhry, S, Shaw, AL, Syrris, P, Ward, D   +11 more
core   +1 more source

Protective Effects and Target Network Analysis of Ginsenoside Rg1 in Cerebral Ischemia and Reperfusion Injury: A Comprehensive Overview of Experimental Studies

Cells, 2018
Cerebral ischemia-reperfusion is a complicated pathological process. The injury and cascade reactions caused by cerebral ischemia and reperfusion are characterized by high mortality, high recurrence, and high disability. However, only a limited number of
Weijie Xie, P. Zhou, Yifan Sun, Xiangbao Meng, Ziru Dai, Guibo Sun, Xiaobo Sun   +6 more
semanticscholar   +1 more source

A High‐Throughput AngioPlate Platform with Integrated AngioTEER for Modeling and Monitoring Renal Proximal Tubule Injury

Advanced Materials Technologies, EarlyView.
Renal tubular injury is a major contributor to kidney disease, yet remains poorly understood due to the lack of predictive models. This study presents a high‐throughput 3D renal proximal tubule model on the AngioPlate platform integrated with automated TEER measurements (AngioTEER), enabling real‐time monitoring of drug‐induced nephrotoxicity ...
Shravanthi Rajasekar, Anushree Chakravarty, Kimia Asadi Jozani, Brenda Truong, Matana Hendrickson, Ahmed Attia, Muna Sabouny, Anna Basatskaya, Sergi Clotet‐Freixas, Madeleine Ludlow, Alexander Sotra, Dawn S. Y. Lin, Feng Zhang, Boyang Zhang   +13 more
wiley   +1 more source

Damage to Mitochondrial Complex I During Cardiac Ischemia Reperfusion Injury is Reduced Indirectly by Anti-anginal Drug Ranolazine [PDF]

, 2012
Ranolazine, an anti-anginal drug, is a late Na+ channel current blocker that is also believed to attenuate fatty acid oxidation and mitochondrial respiratory complex I activity, especially during ischemia.
Antholine, William E., Camara, Amadou K.S., Gadicherla, Ashish K., Stowe, David F., Yang, Meiying   +4 more
core   +2 more sources

The protective role of curcumin in myocardial ischemia–reperfusion injury

Journal of Cellular Physiology, 2018
Coronary artery disease (CAD) is a well‐known pathological condition that is characterized by high morbidity and mortality. The main pathological manifestation of CAD is myocardial injury due to ischemia–reperfusion (I–R).
A. Mokhtari-Zaer, Narges Marefati, S. Atkin, A. Butler, A. Sahebkar   +4 more
semanticscholar   +1 more source

Rewiring Neuroimmunity: Nanoplatform Innovations for CNS Disease Therapy

Advanced Therapeutics, EarlyView.
This review explores emerging nanoplatform strategies designed to modulate neuroimmune responses for treating central nervous system (CNS) disorders. It examines structural and microenvironmental barriers, advances in multifunctional and targeted nanotechnologies, and highlights clinical progress and translational challenges, offering insights into the
Muhammad Usman Akbar, Weiwei Guo, Xin Shen, Yimeng Fang, Yilin Liu, Peng‐Yuan Wang, Roey Elnathan, Yaping Chen   +7 more
wiley   +1 more source

SiO2 nanoparticles as disruptors of endogenous resolution mechanisms of inflammatory responses that exacerbate pneumonia

Scientific Reports
Occupational exposure to engineered nanomaterials (ENMs) is increasing in the workplace and can impact human health. Amorphous silicon dioxide nanoparticles (SiO2 NPs) are widely produced respirable ENMs used in commercial products.
Luciana Pádua Tavares, Stephania Libreros, Dimitrios Bitounis, Robert Nshimiyimana, Philip Demokritou, Charles N. Serhan, Bruce D. Levy   +6 more
doaj   +1 more source