Results 111 to 120 of about 199,564 (290)
This study identifies Pirin (PIR), an iron‐binding protein, as a critical ferroptosis suppressor in colorectal cancer through lipid membrane remodeling. PIR, induced by NRF2 during ferroptotic stress, transcriptionally regulates PLA2G4A to shift cellular lipid composition away from ferroptosis‐permissive polyunsaturated phospholipids.
Wei Shi +10 more
wiley +1 more source
Neuroprotective potential for mitigating ischemia-reperfusion-induced damage
Reperfusion following cerebral ischemia causes both structural and functional damage to brain tissue and could aggravate a patient’s condition; this phenomenon is known as cerebral ischemia-reperfusion injury.
Zi Ye +8 more
doaj +1 more source
Inducing Ischemia-reperfusion Injury in the Mouse Ear Skin for Intravital Multiphoton Imaging of Immune Responses [PDF]
Chi Ching Goh +5 more
openalex +1 more source
HUWE1 in Skeletal Muscle Prevents Muscle Fatigue via Maintaining Iron and Calcium Homeostasis
This study investigates the impact of iron homeostasis on exercise. Loss of the HECT domain‐containing ubiquitin ligase E3 (HUWE1) in skeletal muscle restrains the exercise performance in mice with downregulated ferroportin expression leading to iron overload, which is ameliorated by dietary iron restriction.
Huike Jiao +10 more
wiley +1 more source
Role of tubular cell-derived exosomes in renal ischemia reperfusion injury
Renal ischemia reperfusion injury refers to a pathophysiological phenomenon that aggravates the degree of renal injury due to the restoration of blood supply after transient ischemia of renal tissue.
Jin-zhu Huang +7 more
doaj +1 more source
Mitochondrial Adaptation to Mechanical Stress in Cardiac Ageing and Disease
Mechanical forces shape the heart's energy factories. This review explores how mitochondria in cardiac cells sense and respond to biomechanical stress, altering their structure, positioning, and metabolism. By linking mechanical cues to mitochondrial adaptation, the article highlights pathways driving heart disease and points to new strategies for ...
Aishwarya Prakash, Thomas Iskratsch
wiley +1 more source
Endotoxin tolerance protects against local hepatic ischemia/reperfusion injury in the rat [PDF]
Emilio Domínguez Fernández +6 more
openalex +1 more source

