Results 101 to 110 of about 1,080,711 (303)

Cav3.2 channel regulates cerebral ischemia/reperfusion injury: a promising target for intervention

Neural Regeneration Research
Calcium influx into neurons triggers neuronal death during cerebral ischemia/reperfusion injury. Various calcium channels are involved in cerebral ischemia/reperfusion injury. Cav3.2 channel is a main subtype of T-type calcium channels.
Feibiao Dai, Chengyun Hu, Xue Li, Zhetao Zhang, Hongtao Wang, Wanjun Zhou, Jiawu Wang, Qingtian Geng, Yongfei Dong, Chaoliang Tang   +9 more
doaj   +1 more source

Targeting GALNT7 Disrupts the TAZ O‐GalNAcylation Feedback Loop to Suppress Gallbladder Cancer Progression

Advanced Science, EarlyView.
Aberrant GALNT7‐mediated O‐GalNAcylation stabilizes TAZ to drive gallbladder cancer progression through a feed‐forward transcriptional loop. Structure‐based screening identifies Olaparib as a potent GALNT7 antagonist that disrupts this oncogenic axis, providing an immediate therapeutic strategy for this aggressive malignancy.
Peng Qiu, Ming Zhang, Yunxiang Feng, Yibo Deng, Kai Zhao, Xiangyu Li, Yun Lu, Li Tian, Tao Yang, Wei Yao, Jianming Wang, Zhengdong Deng   +11 more
wiley   +1 more source

Microenvironment‐Responsive Nanomedicine Enables Vertical Modulation of Mitochondrial Pathological Networks in Myocardial Ischemia–Reperfusion Injury

Advanced Science, EarlyView.
A mitochondria‐targeted, microenvironment‐responsive nanoplatform enables pH/ROS‐triggered co‐delivery of berberine and isoliensinine to orchestrate ROS scavenging, inflammation suppression, and apoptosis inhibition. This vertical modulation of mitochondrial pathological networks preserves mitochondrial function and effectively mitigates myocardial ...
Jue Wang, Jia Zhou, Wenqin Yuan, Tianjiao Zhao, Yunying Huang, Yingci Xia, Yuting Lin, Fei Li, Qiong Huang, Chong Liu, Kelong Ai, Qun Qin   +11 more
wiley   +1 more source

Transient limb ischemia induces remote ischemic preconditioning in vivo [PDF]

, 2002
Background-Ischemic preconditioning reduces local tissue injury caused by subsequent ischemia-reperfusion (IR), but may also have a salutary effect on IR injury of tissues remote from those undergoing preconditioning.
Hoschtitzky, JA, Sorensen, K, Redington, AN, Mortensen, UM, Kristiansen, SB, Kharbanda, RK, Vogel, M, Kharbanda, Rajesh, White, PA, Schmidt, MR, MacAllister, R   +10 more
core   +1 more source

Aldehyde dehydrogenase 2 overexpression inhibits neuronal apoptosis after spinal cord ischemia/reperfusion injury

Neural Regeneration Research, 2017
Aldehyde dehydrogenase 2 (ALDH2) is an important factor in inhibiting oxidative stress and has been shown to protect against renal ischemia/reperfusion injury.
Xing-zhen Liu, Xin Sun, Kang-ping Shen, Wen-jie Jin, Zhi-yi Fu, Hai-rong Tao, Zhi-xing Xu   +6 more
doaj   +1 more source

Probiotic‐Derived Vesicles Rectally Delivered via Thermo‐Gelling Copolymer Promote Mucosal Healing and Reduce Inflammation in Ulcerative Colitis

Advanced Science, EarlyView.
A thermo‐responsive rectal delivery platform integrating probiotic‐derived extracellular vesicles within a hyaluronic acid‐based copolymer enables localized and sustained therapy for ulcerative colitis. The formulation effectively suppresses inflammation, promotes macrophage polarization toward a regenerative phenotype, restores epithelial barrier ...
Ayushi Mairal, Ubaid Tariq, Shreya Mehrotra, Saravanan Matheshwaran, Jan Marsal, Ashok Kumar   +5 more
wiley   +1 more source

Intravenous sodium nitrite in acute ST-elevation myocardial infarction: a randomized controlled trial (NIAMI) [PDF]

, 2014
AimDespite prompt revascularization of acute myocardial infarction (AMI), substantial myocardial injury may occur, in part a consequence of ischaemia reperfusion injury (IRI). There has been considerable interest in therapies that may reduce IRI.
Singh, Satnam, Lim, Pitt O, Christopher Neil (433186), Bruce, M, Broadhurst, Paul, Madhani, Melanie; id_orcid, Nishat Siddiqi (7733786), Schwarz, Konstantin, Awsan, Noman, Jansen, Else, McPherson, Gladys, Dawson, Dana, Slattery, Elaine, Struthers, Allan, McDonald, Alison, Rhodes, Jonathan, Neil, Christopher, Toff, William, Bruce, M., Garg, Deepak, Siddiqi, N, Firoozi, Sami, Kaski, JC, Madhani, M., Nicholas Boon (7733804), Kaski, Juan-Carlo, Sofia Papadopoulou (7733789), Horowitz, J, Bennett, Lorraine, Horowitz, J., Frenneaux, Michael, Boon, N., Bruce, Margaret, Hildick-Smith, David, Lim, P., Neil, C., Nightingale, Peter, Pitt O. Lim (7733795), Graeme MacLennan (275485), Hannah, Andrew, Feelisch, M., Melanie Madhani (3851305), Roberts, Elved, Dawson, D, David Hildick-Smith (7733798), Madhani, M, Kaski, Juan Carlos, Lim, PO, Stewart, Andrew, Cooter, Nina, Rajendran, Sharmalar, Horowitz, John, Lang, Chim, Papadopoulou, Sofia A., NIAMI investigators, Jagpal, Baljit, Cotton, S, Siddiqi, N., Gonzalvez, Fatima, Feelisch, Martin, Madhani, Melanie, Boon, Nicholas, Nicholas Bunce (7733792), Brown, Sue, Roy, David, Bunce, N., Bunce, N, Papadopoulou, S, Dawson, D., Frenneaux, M., Michael Frenneaux (3576296), Davidson, Tracey, Siddiqi, Nishat, Dargie, Henry, Feelisch, M, Neil, C, Dana Dawson (7020656), Hildick-Smith, D., Frenneaux, M, Hildick-Smith, D, Bunce, Nicholas, NIAMI investigators (7733810), Cotton, Seonaidh, Seonaidh Cotton (503485), de Belder, Adam, Papadopoulou, S., Black, Marilyn, Kaski, J., Hogg, Duncan, Dautov, Rustem, Metcalfe, Malcolm, Bogle, Richard, Cotton, S., Boon, N, Martin Feelisch (358503), John Horowitz (7733801), Margaret Bruce (782483), Lim, Pitt O., MacLennan, G, Cotton, Seonaidh Claire, Juan Carlos Kaski (7733807), Maclennan, Graeme, Papadopoulou, Sofia, MacLennan, G.   +103 more
core   +1 more source

Human Dental Pulp Stem Cell Secretome Restores Ischemic Stroke–Impaired Motor and Cognitive Functions by Reprogramming Redox and Inflammatory Signaling

Advanced Science, EarlyView.
Human dental pulp stem cell secretome emerges as a cell‐free therapeutic strategy for ischemic stroke by reprogramming redox and inflammatory signaling. hDPSC secretome‐derived antioxidant and immunomodulatory factors suppress the TLR4–NOX–ROS–NF‐κB axis, reduce microglial inflammatory responses and apoptosis, and promote neurogenesis, angiogenesis ...
Kyung‐Joo Seong, Sehoon Park, Sun‐Woong Bae, Daseul Kim, Jin Ho Lee, Won‐Seok Choi, Zee‐Yong Park, Ji‐Yeon Jung, Won‐Jae Kim   +8 more
wiley   +1 more source

The effect of liver warm ischaemia reperfusion injury and modulation on bile composition evaluated by magnetic resonance spectroscopy [PDF]

, 2015
Orthotopic liver transplantation has become the preferred treatment for a variety of end-stage liver disease. As competency and survival rates increase, so does increasing demand, which puts greater strain on a static donor pool.
Hafez, T
core  

Release of TNF-α during myocardial reperfusion depends on oxidative stress and is prevented by mast cell stabilizers [PDF]

, 2003
Objectives: Our study sought to elucidate the role of oxidative stress for shedding of tumor necrosis factor-α (TNF-α) and for activating TNF-α-converting enzyme (TACE).
Welsch, Ulrich, Sommerhoff, Christian P., Gilles, Stefanie, Zahler, Stefan, Becker, Bernhard F.   +4 more
core   +1 more source