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Pathophysiology of reperfusion injury

2011
INTRODUCTION Ischaemia-Reperfusion Injury (IRI) is defined as the paradoxical exacerbation of cellular dysfunction and death, following restoration of blood flow to previously ischaemic tissues. Reestablishment of blood flow is essential to salvage ischaemic tissues.
Cowled, P., Fitridge, R.
openaire   +2 more sources

The NLRP3 Inflammasome Inhibitor, OLT1177 (Dapansutrile), Reduces Infarct Size and Preserves Contractile Function After Ischemia Reperfusion Injury in the Mouse

Journal of Cardiovascular Pharmacology, 2019
Background: Activation of the NLRP3 inflammasome is a primary driver of sterile inflammation in response to myocardial ischemia reperfusion. Pharmacologic inhibitors of the NLRP3 inflammasome are being developed.
S. Toldo   +8 more
semanticscholar   +1 more source

Cytokines and Reperfusion Injury

Journal of Cardiac Surgery, 1993
Myocardial dysfunction following prolonged ischemia and reperfusion is at least partially dependent upon adhesion of neutrophils to myocardial and endothelial cells. Neutrophils are thought to contribute to reperfusion injury by two mechanisms: impairment of the microvasculature by physical obstruction, and secretion of products that damage ...
openaire   +2 more sources

Cytokines and reperfusion injury

Neurology, 1997
There is increasing evidence that the inflammatory response plays an important role in the potentiation of central nervous system (CNS) ischemic injury. Much of this inflammatory response appears to be mediated by interleukins (IL), a multifunctional subclass of cytokines.
openaire   +2 more sources

mTOR and Beclin1: Two key autophagy‐related molecules and their roles in myocardial ischemia/reperfusion injury

Journal of Cellular Physiology, 2019
Autophagy is the general term of lysosomal degradation of substances in cells, which is considered the key to maintaining the normal structure and function of the heart.
Binhao Shi   +4 more
semanticscholar   +1 more source

Renal Perfusion/Reperfusion Injuries

Journal of Urology, 1988
Apres un rappel sur la physiologie renale de la perturbation de la perfusion, on etudie la biologie cellulaire de la lesion renale ischemique, les perturbations hormonales au cours de l'ischemie renale, la prevention et le traitement de l'insuffisance renale aigue ...
openaire   +2 more sources

Cell Death Mechanisms in Cerebral Ischemia–Reperfusion Injury

Neurochemical Research, 2022
Qian-ru Zhang   +4 more
semanticscholar   +1 more source

Reperfusion injury.

New horizons (Baltimore, Md.), 1996
Reperfusion injury, precipitated by lack of oxygen, is likely to play a major role in many clinical conditions, including shock, coronary artery occlusion disease, and solid organ transplantation. Certain tissues, such as the intestinal mucosa, may be especially susceptible because of the specific microvascular anatomy.
A, Ar'Rajab, I, Dawidson, R, Fabia
openaire   +1 more source

Controlled Reperfusion Against Ischemia Reperfusion Injury

2018
Recanalization and reperfusion after an ischemic stroke sometimes could be harmful and deadly, and controlled perfusion may be a potential solution. This article summarized controlled perfusion literature, both animal and clinical, on heart, lung, kidney, and limbs and compared with brain controlled perfusion.
Weijian Jiang   +3 more
openaire   +1 more source

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