Results 221 to 230 of about 889,250 (400)

PRDM1+ Malignant Cells Mediate an Immunosuppressive Landscape and Resistance to Neoadjuvant Chemoradiotherapy and Immunotherapy in Esophageal Squamous Cell Carcinoma

Advanced Science, EarlyView.
Integrated scRNA‐seq, scTCR‐seq analysis, and functional assays identify PRDM1+ malignant epithelial cells with hyper lipid peroxidation characteristics that demonstrate reduced responsiveness to the nICRT treatment. Principal factor PRDM1 activates cysteine metabolism genes to modulate lipid peroxidation (an intrinsic cellular pathway related to ...
Dijian Shen, Rui Li, Yong She, Xuefei Liu, Yuanyang Huang, Yongling Ji, Keying Chen, Zhengbo Song, Runzhe Chen, Xuan Li, Qi Zhao, Qixun Chen, Ming Chen   +12 more
wiley   +1 more source

Oligoclonal B cell expansion and passenger fusion genes predict response to Nivolumab in recurrent ovarian cancer: phase II Kyoto trial. [PDF]

Cancer Immunol Immunother
Murakami R, Hamanishi J, Brown JB, Hosoe Y, Kobayashi T, Konishi T, Miyamoto T, Mizuno R, Taki M, Yamanoi K, Yamaguchi K, Mandai M.   +11 more
europepmc   +1 more source

Gain and loss of plasmid-borne antibiotic resistance genes are associated with their chromosomal counterparts and the broader plasmid gene repertoire in Enterobacteriaceae [PDF]

Yang Liu, Yue Liu, Yue Liu, Yue Liu
openalex   +1 more source

Expanding life's repertoire [PDF]

, 2001
Magdalena Skipper
openalex   +1 more source

Animal-associated marine acidobacteria with a rich natural product repertoire

, 2023
Lucas Paoli
openalex   +1 more source

SETDB2 Mitigates Podocyte Dysfunction in Diabetic Kidney Disease Through Epigenetic Silencing of SMAD3

Advanced Science, EarlyView.
SETDB2 epigenetically represses Smad3 transcription by increasing H3K9me3 enrichment at its promoter, thereby mitigating podocyte dysfunction in DKD. The transcription factor TCF21 binds directly to the Setdb2 promoter and enhances its expression in podocytes. Abstract Podocyte dysfunction represents both an early pathological hallmark and a key driver
Lanfang Li, Shimin Jiang, Qi Jin, Peng Qu, Yingjie Guo, Xushan Lan, Xinyu Li, Cuiting Sun, Sinan Ai, Xin Li, Weiliang Sun, Jing Guo, Wenge Li, Liang Peng, Lihong Liu   +14 more
wiley   +1 more source

Change of voltage‐gated sodium channel repertoire in skeletal muscle of a MuSK myasthenia gravis mouse model [PDF]

Olena Butenko, Stine Marie Jensen, Yvonne E. Fillié‐Grijpma, Robyn Verpalen, Jan J.G.M. Verschuuren, Silvère M. van der Maarel, Maartje G. Huijbers, Jaap J. Plomp   +7 more
openalex   +1 more source

Building the repertoire of dispensable chromosome regions in Bacillus subtilis entails major refinement of cognate large-scale metabolic model [PDF]

, 2012
Kosei Tanaka, Christopher S. Henry, Jenifer F. Zinner, Edmond Jolivet, Matthew Cohoon, Fangfang Xia, Vladimir Bidnenko, S. Dusko Ehrlich, Rick Stevens, Philippe Noirot   +9 more
openalex   +1 more source

Alphaviral Capsid Proteins Inhibit Stress Granule Assembly via Competitive RNA Binding With G3BP1

Advanced Science, EarlyView.
Stress granules exert antiviral functions. This study illustrates a conserved function of alphaviral capsid proteins in modulating stress granules. Oligomerization mediated by a helical motif coupled with a positively charged intrinsically disordered region (IDR) directly competes with G3BP1 for RNA binding, thereby disrupting G3BP1‐RNA liquid–liquid ...
Yun Zhang, Yi Liu, Zhiying Yao, Haolong Lai, Xiaoxin Chen, Ziqiu Wang, Yiqiong Bao, Tingting Li, Xiaoming Zhou, Xiabin Chen, Peiguo Yang   +10 more
wiley   +1 more source

Evolution of the Metazoan Protein Domain Repertoire Revealed by a Birth-Death-Gain Model. [PDF]

J Mol Evol
Xiao Y, Stolzer M, Wasserman L, Durand D.   +3 more
europepmc   +1 more source