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Analysis of rat repetitive DNA sequences
Biochemistry, 1978Parameters of repetitive sequence organization have been measured in the rat genome. Experiments using melting, hydroxylapatite binding, and single strand specific nuclease digestion have been used to measure the number, length, and arrangement of repeated DNA sequences.
W R, Pearson, J R, Wu, J, Bonner
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Ageing, repetitive genomes and DNA damage
Nature Reviews Molecular Cell Biology, 2004The mitochondrial production of reactive oxygen species is inversely proportional to longevity in animals. A key question now is, which molecules, among those that are oxidized, affect the lifespan of the organism most significantly?
Michael R, Lieber, Zarir E, Karanjawala
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2019
It is well established that conifer genomes are comprised largely of noncoding and repetitive DNA (Chaps. 2 and 3). However, the much smaller fraction of the genome comprised of protein-coding genes has been the focus of most research (see Chaps. 5, 6, and 7) because these genes ultimately lead to phenotypes and the genetic differences among species ...
David B. Neale, Nicholas C. Wheeler
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It is well established that conifer genomes are comprised largely of noncoding and repetitive DNA (Chaps. 2 and 3). However, the much smaller fraction of the genome comprised of protein-coding genes has been the focus of most research (see Chaps. 5, 6, and 7) because these genes ultimately lead to phenotypes and the genetic differences among species ...
David B. Neale, Nicholas C. Wheeler
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Repetitive DNA Hypomethylation in Multiple Myeloma
Blood, 2008Abstract Multiple myeloma (MM) is a malignant proliferation of bone marrow plasma cells characterized by a wide spectrum of genetic and epigenetic changes. Global hypomethylation of repetitive genomic sequences such as long interspersed nuclear elements-1 (LINE-1) and Alu repetitive elements (approximately 500.000 and 1.4 million in the ...
S. Fabris +11 more
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Diagnostic applications of repetitive DNA sequences
Clinica Chimica Acta, 1992Different diagnostic applications are discussed for various categories of repetitive DNA sequences. Since all eukaryotes are characterized by genomic redundancy, these sensitive, rapid, and comparatively simple techniques are revolutionizing many fields in clinical and experimental diagnostics.
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Moderately Repetitive DNA in Evolution
1982Publisher Summary This chapter discusses the role of moderately repetitive DNA in evolution. Moderately repetitive sequences are found as dispersed segments among unrelated, often single-copy DNA sequences throughout the genome, while simple-sequence DNAs occur in long tandemly repeated clusters, frequently at the centromeric or telomeric regions of ...
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Interspersed repetitive DNA from Plasmodium falciparum
Molecular and Biochemical Parasitology, 1988An interspersed repetitive DNA element from the Camp strain of the human malaria parasite Plasmodium falciparum was cloned and sequenced. The element is repeated at least 11 times in the genome, is a minimum of 2.0 kilobases long and maps to eight or more different parasite chromosomes. The cloned DNA includes a 1.0 kilobase open reading frame.
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