Results 1 to 10 of about 79,729 (116)
Rapid and Sensitive Detection of Repetitive Nucleic Acid Sequences Using Magnetically Modulated Biosensors [PDF]
ACS Omega, 2019 Repetitive DNA sequences are abundant in the genome of most biological species. These sequences are naturally "preamplified", which makes them a preferential target for a variety of biological assays. Current methods to detect specific DNA sequences are based on the quantitative polymerase chain reaction (PCR), which relies on target amplification by ...
Michael Margulis, Amos Danielli
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Advances in the application of CRISPR-Cas technology in rapid detection of pathogen nucleic acid
Frontiers in Molecular Biosciences, 2023 Clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated proteins (Cas) are widely used as gene editing tools in biology, microbiology, and other fields.
Xiaoping Li +18 more
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Extracellular vesicle-associated repetitive element DNAs as candidate osteosarcoma biomarkers
Scientific Reports, 2021 Osteosarcoma (OS) is the most common malignant bone tumor in children and young adults. Despite that high-risk factors have been identified, no test for early detection is available.
Linda Cambier +8 more
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Comprehensive Regulation of Liquid–Liquid Phase Separation of Polypeptides
Molecules, 2023 The elucidation of the molecular driving forces responsible for Liquid–liquid Phase Separation (LLPS) of proteins and nucleic acids within living cells is crucial for understanding its biological functions and its role in related diseases. In the present
Yanwei Wang +3 more
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Fast and non-toxic in situ hybridization without blocking of repetitive sequences. [PDF]
PLoS ONE, 2012 Formamide is the preferred solvent to lower the melting point and annealing temperature of nucleic acid strands in in situ hybridization (ISH). A key benefit of formamide is better preservation of morphology due to a lower incubation temperature. However,
Steen H Matthiesen, Charles M Hansen
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The Simple Biology of Flipons and Condensates Enhances the Evolution of Complexity
Molecules, 2021 The classical genetic code maps nucleotide triplets to amino acids. The associated sequence composition is complex, representing many elaborations during evolution of form and function. Other genomic elements code for the expression and processing of RNA
Alan Herbert
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General cell-binding activity of intramolecular G-quadruplexes with parallel structure. [PDF]
PLoS ONE, 2013 G-quadruplexes (G4s) are four-stranded nucleic acid structures adopted by some repetitive guanine-rich sequences. Putative G-quadruplex-forming sequences (PQSs) are highly prevalent in human genome.
Tianjun Chang +7 more
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Consistent ultra-long DNA sequencing with automated slow pipetting
BMC Genomics, 2021 Background Oxford Nanopore Technologies’ instruments can sequence reads of great length. Long reads improve sequence assemblies by unambiguously spanning repetitive elements of the genome.
Trent M. Prall +7 more
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Frontiers in Oncology, 2021 Repetitive DNA sequences (repeats) colonized two-third of human genome and a majority of repeats comprised of transposable genetic elements (TE). Evolutionary distinct categories of TE represent nucleic acid sequences that are repeatedly copied from and ...
Gennadi V. Glinsky, Gennadi V. Glinsky
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Nature Communications, 2023 Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are neurodegenerative diseases that exist on a clinico-pathogenetic spectrum, designated ALS/FTD.
Federica Raguseo +15 more
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