Results 11 to 20 of about 116,375 (241)

Solving the riddle of codon usage preferences: a test for translational selection [PDF]

, 2004
Translational selection is responsible for the unequal usage of synonymous codons in protein coding genes in a wide variety of organisms. It is one of the most subtle and pervasive forces of molecular evolution, yet, establishing the underlying causes ...
dos Reis, M., Savva, Renos, Wernisch, Lorenz   +2 more
core   +6 more sources

Nucleic acid detection aboard the International Space Station by colorimetric loop‐mediated isothermal amplification (LAMP)

FASEB bioAdvances, 2020
Human spaceflight endeavors present an opportunity to expand our presence beyond Earth. To this end, it is crucial to understand and diagnose effects of long‐term space travel on the human body.
Julian Rubinfien, K. D. Atabay, N. Nichols, N. Tanner, J. A. Pezza, M. M. Gray, Brandon M. Wagner, J. Poppin, Jordan T. Aken, Emily J Gleason, Kevin D. Foley, D. S. Copeland, Sebastian Kraves, Ezequiel Alvarez Saavedra   +13 more
semanticscholar   +1 more source

General cell-binding activity of intramolecular G-quadruplexes with parallel structure. [PDF]

PLoS ONE, 2013
G-quadruplexes (G4s) are four-stranded nucleic acid structures adopted by some repetitive guanine-rich sequences. Putative G-quadruplex-forming sequences (PQSs) are highly prevalent in human genome.
Tianjun Chang, Cui Qi, Jie Meng, Nan Zhang, Tao Bing, Xianda Yang, Zehui Cao, Dihua Shangguan   +7 more
doaj   +1 more source

Consistent ultra-long DNA sequencing with automated slow pipetting

BMC Genomics, 2021
Background Oxford Nanopore Technologies’ instruments can sequence reads of great length. Long reads improve sequence assemblies by unambiguously spanning repetitive elements of the genome.
Trent M. Prall, Emma K. Neumann, Julie A. Karl, Cecilia G. Shortreed, David A. Baker, Hailey E. Bussan, Roger W. Wiseman, David H. O’Connor   +7 more
doaj   +1 more source

Delineation of individual human chromosomes in metaphase and interphase cells by in situ suppression hybridization using recombinant DNA libraries [PDF]

, 1988
A method of in situ hybridization for visualizing individual human chromosomes from pter to qter, both in metaphase spreads and interphase nuclei, is reported.
B Trask, C Cremer, D Pinkel, D Pinkel, D. C. Ward, DA Agard, DJ Brigati, DJ Finney, GA Rappold, GD Johnson, GJ Brakenhoff, H Hamada, HE McDermid, HJ Cooke, J. Borden, JE Landegent, JG White, JR Gosden, JS Waye, L Hens, L Manuelidis, L Manuelidis, L Manuelidis, L Manuelidis, L Manuelidis, L. Manuelidis, LG Davis, M Schardin, MA Dilla Van, ML Mendelsohn, P. Lichter, PG Sealey, PR Langer, RJ Britten, T Cremer, T Cremer, T Cremer, T Cremer, T Maniatis, T. Cremer   +39 more
core   +1 more source

Blueprint for a high-performance biomaterial: full-length spider dragline silk genes. [PDF]

, 2007
Spider dragline (major ampullate) silk outperforms virtually all other natural and manmade materials in terms of tensile strength and toughness. For this reason, the mass-production of artificial spider silks through transgenic technologies has been a ...
Ayoub, Nadia A, Collin, Matthew A, Garb, Jessica E, Hayashi, Cheryl Y, Tinghitella, Robin M   +4 more
core   +11 more sources

The ALS/FTD-related C9orf72 hexanucleotide repeat expansion forms RNA condensates through multimolecular G-quadruplexes

Nature Communications, 2023
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are neurodegenerative diseases that exist on a clinico-pathogenetic spectrum, designated ALS/FTD.
Federica Raguseo, Yiran Wang, Jessica Li, Marija Petrić Howe, Rubika Balendra, Anouk Huyghebaert, Devkee M. Vadukul, Diana A. Tanase, Thomas E. Maher, Layla Malouf, Roger Rubio-Sánchez, Francesco A. Aprile, Yuval Elani, Rickie Patani, Lorenzo Di Michele, Marco Di Antonio   +15 more
doaj   +1 more source

Complete Sequences of Organelle Genomes from the Medicinal Plant Rhazya Stricta (Apocynaceae) and Contrasting Patterns of Mitochondrial Genome Evolution Across Asterids [PDF]

, 2014
Rhazya stricta is native to arid regions in South Asia and the Middle East and is used extensively in folk medicine to treat a wide range of diseases.
Baeshen, Mohammed N., Baeshen, Nabih A., Jansen, Robert K., Mutwakil, Mohammed H. Z., Park, Seongjun, Ruhlman, Tracey A., Sabir, Jamal S. M., Sabir, Meshaal J.   +7 more
core   +1 more source

Repetitive DNA loci and their modulation by the non-canonical nucleic acid structures R-loops and G-quadruplexes

The Nucleus, 2017
Cells have evolved intricate mechanisms to maintain genome stability despite allowing mutational changes to drive evolutionary adaptation. Repetitive DNA sequences, which represent the bulk of most genomes, are a major threat to genome stability often ...
Amanda C. Hall, L. A. Ostrowski, Violena Pietrobon, Karim Mekhail   +3 more
semanticscholar   +1 more source

STR technique for the detection of contamination by exogenous DNA in paraffin blocks and histological slides

Surgical and Experimental Pathology, 2019
Gastrointestinal Stromal Tumors (GIST) present different types of mutations that may or may not be sensitive to specific target therapy. The laboratory procedure required to prepare histological sections traditionally demands multiple steps, making the ...
Denise Barcelos, Karina Funabashi, Susana Mazloum, Mariana Fernandes, Leonardo Cardili   +4 more
doaj   +1 more source