Results 61 to 70 of about 1,173,714 (339)
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Perspectives on Psychological Science, 2012 Replication is held as the gold standard for ensuring the reliability of published scientific literature. But conducting direct replications is expensive, time-consuming, and unrewarded under current publication practices. So who will do them? Our answer is that students in laboratory classes should replicate recent findings as part of their training ...
uploaded via Dissemin +2 more
openaire +3 more sources
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
EntropyComplex systems pose significant challenges to traditional scientific and statistical methods due to their inherent unpredictability and resistance to simplification.
Timothy Davey
doaj +1 more source
Replicability of Experiment [PDF]
, 2015 The replicability of experiment is routinely offered as the gold standard of evidence. I argue that it is not supported by a universal principle of replicability in inductive logic.
Norton, John D.
core +5 more sources
An evaluation of the replicability of analyses using synthetic health data
Scientific ReportsSynthetic data generation is being increasingly used as a privacy preserving approach for sharing health data. In addition to protecting privacy, it is important to ensure that generated data has high utility.
Khaled El Emam +3 more
semanticscholar +1 more source
Scientific Reports, 2020 Cancer drug development has been riddled with high attrition rates, in part, due to poor reproducibility of preclinical models for drug discovery. Poor experimental design and lack of scientific transparency may cause experimental biases that in turn ...
P. Larsson +8 more
semanticscholar +1 more source
PLoS Biology, 2021 The replicability of research results has been a cause of increasing concern to the scientific community. The long-held belief that experimental standardization begets replicability has also been recently challenged, with the observation that the ...
Takuji Usui +4 more
semanticscholar +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
BirdsMore than 40 hypotheses predict associations between features of nest architecture and at least one measure of reproductive success. However, quantitative studies of reproductive consequences of nest characteristics remain scarce.
Marcel M. Lambrechts, D. Charles Deeming
doaj +1 more source