Results 71 to 80 of about 220,529 (335)

Translophagy—A potential link between autophagy impairment and translational errors

open access: yesFEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk   +11 more
wiley   +1 more source

Reproducibility and Replicability in Economic Science [PDF]

open access: yes, 2018
https://deepblue.lib.umich.edu/bitstream/2027.42/143813/1/Reproducibility and Replicability in Economic Science Levenstein NAS presentation February 22, 2018.pdf59129Description of Reproducibility and Replicability in Economic Science Levenstein NAS ...
Levenstein, Margaret C.
core   +4 more sources

A Systematic Review of Eye-Tracking Technology in Second Language Research

open access: yesLanguages
Eye-tracking has become increasingly popular in second language (L2) research. In this study, we systematically reviewed 111 eye-tracking studies published in 17 L2 journals to explore the application and replicability of eye-tracking technology in L2 ...
Xin Hu, Vahid Aryadoust
doaj   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

open access: yesFEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell   +2 more
wiley   +1 more source

A practical, step-by-step, guide to taxonomic comparisons using Procrustes geometric morphometrics and user-friendly software (part A): introduction and preliminary analyses

open access: yesEuropean Journal of Taxonomy
Taxonomy lays the foundations for the study of biodiversity and its conservation. Procrustean geometric morphometrics (GMM) is a most common technique for the taxonomic assessment of phenotypic population differences.
Andrea Cardini
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

open access: yesFEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices   +3 more
wiley   +1 more source

Replication control: Choreographing replication origins [PDF]

open access: yesCurrent Biology, 1998
Budding yeast replication origins are activated during S phase according to a predetermined temporal programme. Two recent studies indicate that this programme is executed, at least in part, by the S-phase-promoting cyclins that act to assemble a pre-initiation complex which includes the Cdc45 protein.
openaire   +2 more sources

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

A Reproducible Analysis of Sequential Recommender Systems

open access: yesIEEE Access
Sequential Recommender Systems (SRSs) have emerged as a highly efficient approach to recommendation systems. By leveraging sequential data, SRSs can identify temporal patterns in user behaviour, significantly improving recommendation accuracy and ...
Filippo Betello   +6 more
doaj   +1 more source

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