Results 51 to 60 of about 108,626 (229)

Simulating Real-World Slips: Enhanced Kinematic and Neuromuscular Responses to Experimental Slips in the Early vs. Late Stance Phase in Young and Older Adults

Bioengineering
Slips are a leading cause of injury and hospitalization among at-risk individuals. Replicating real-world slips by experimental, mechanical perturbations is essential for characterizing reactive balance mechanisms activated during near-fall situations ...
Marina Geissmann, Nicole Sarah Holliger, Lennart Carlson Neumann, Antonia Maria Eilfort, Linard Filli   +4 more
doaj   +1 more source

Concept Analysis and Implementation Framework of Dementia Day Care Service [PDF]

Zhongguo quanke yixue
Day care service is an important component of the community care service system for elderly people with dementia. However, the concept of dementia day care has not been unified, and its connotation and implementation framework have not been clarified ...
LI Xianwen, LI Xinru, LIU Haining, YIN Yueheng, SHAN Enfang, DING Yaping, NIU Shuzhen, XING Ying
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Team effectiveness in a virtual environment: The role of trust and knowledge sharing [PDF]

Strategic Management
Background: In recent years, research efforts have focused on understanding virtual environments and the importance of collaboration in such environments.
Hodžić Naida, Efendić Amina, Kapo Amra   +2 more
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Roadblocks to translational challenges on viral pathogenesis. [PDF]

, 2013
Distinct roadblocks prevent translating basic findings in viral pathogenesis into therapies and implementing potential solutions in the clinic. An ongoing partnership between the Volkswagen Foundation and Nature Medicine resulted in an interactive ...
Deeks, Steven, Drosten, Christian, Picker, Louis, Subbarao, Kanta, Suzich, Joann   +4 more
core   +1 more source

A cluster-randomized controlled trial of the effectiveness of the JUMP Math program of math instruction for improving elementary math achievement.

PLoS ONE, 2019
Students in many western countries struggle to achieve acceptable standards in numeracy despite its recognition as an important 21st century skill.
Tracy Solomon, Annie Dupuis, Arland O'Hara, Min-Na Hockenberry, Jenny Lam, Geraldine Goco, Bruce Ferguson, Rosemary Tannock   +7 more
doaj   +1 more source

Healthy Parent Carers: Acceptability and practicability of online delivery and learning through implementation by delivery partner organisations

Health Expectations, 2023
Background Parent carers of disabled children are at increased risk of physical and mental health problems. The Healthy Parent Carers (HPC) programme is a manualised peer‐led group‐based programme that aims to promote parent carer health and wellbeing ...
Alice Garrood, Gretchen Bjornstad, Aleksandra Borek, Annette Gillett, Jenny Lloyd, Sarah Brand, Mark Tarrant, Susan Ball, Annie Hawton, Annabel McDonald, Mary Fredlund, Fleur Boyle, Vashti Berry, Stuart Logan, Christopher Morris   +14 more
doaj   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Intellectual Property Challenges in Replicating an American Graduate Program in Poland Experiences, Perspectives, and Lessons Learned [PDF]

, 2010
The article delineates some of the challenges in implementing of one of the global trends among universities - increased cooperation and collaboration to create and transfer intellectual property.
Gwarda Gruszczyńska, Edyta, Trzmielak, Dariusz, Zehner II, William Bradley   +2 more
core