Results 101 to 110 of about 2,070,021 (273)
Tumor mutational burden as a determinant of metastatic dissemination patterns
Molecular Oncology, EarlyView.This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal +4 more
wiley +1 more source
Psychologica Belgica, 2019 A crescendo of incidents have raised concerns about whether scientific practices in psychology may be suboptimal, sometimes leading to the publication, dissemination, and application of unreliable or misinterpreted findings.
Lee Jussim +3 more
doaj +1 more source
The Replication Crisis: the Six P’s
, 2023 In a clever bit of rhetoric, Professor Dorothy Bishop came up with “the four horsemen of irreproducibility“: publication bias, low statistical power, p-hacking, and HARKing. In an attempt at more complete coverage of the causes of the replication crisis, here I’m expanding on Dorothy’s four horsemen by adding two more causes, and using different ...
openaire +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Targeting p38α in cancer: challenges, opportunities, and emerging strategies
Molecular Oncology, EarlyView.p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley +1 more source
Behavioral Sciences, 2017 Virtually everybody would agree that life satisfaction is of immense importance in everyday life. Thus, it is not surprising that a considerable amount of research using many different methodological approaches has investigated what the best predictors ...
Bernd Lachmann +10 more
doaj +1 more source
The Solution to Science's Replication Crisis [PDF]
SSRN Electronic Journal, 2016 The solution to science's replication crisis is a new ecosystem in which scientists sell what they learn from their research. In each pairwise transaction, the information seller makes (loses) money if he turns out to be correct (incorrect). Responsibility for the determination of correctness is delegated, with appropriate incentives, to the ...
openaire +2 more sources
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Addressing the "Replication Crisis" in the Field of Parkinson's Disease. [PDF]
J Parkinsons Dis, 2023 Albanese F, Bloem BR, Kalia LV.
europepmc +1 more source
Clinical Science and the Replicability Crisis
, 2016 Psychology is in the early stages of examining a crisis of replicability stemming from several high-profile failures to replicate studies in experimental psychology. This important conversation has largely been focused on social psychology, with some active participation from cognitive psychology.
Jennifer L Tackett +7 more
openaire +3 more sources