Results 51 to 60 of about 2,070,021 (273)
Metascience could rescue the ‘replication crisis’ [PDF]
Nature, 2014 Independent replication of studies before publication may reveal sources of unreliable results, says Jonathan W. Schooler.
openaire +2 more sources
American Statistician, 2018 Statistical inference often fails to replicate. One reason is that many results may be selected for drawing inference because some threshold of a statistic like the P-value was crossed, leading to biased reported effect sizes.
Valentin Amrhein +2 more
semanticscholar +1 more source
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
When numbers fail: do researchers agree on operationalization of published research?
Royal Society Open Science, 2021 Current discussions on improving the reproducibility of science often revolve around statistical innovations. However, equally important for improving methodological rigour is a valid operationalization of phenomena.
Matthias Haucke +2 more
doaj +1 more source
International Review of Theoretical Psychologies, 2021 The “replication crisis” may well be the single most important challenge facing empirical psychological research today. It appears that highly trained scientists, often without understanding the potentially dire long-term implications, have been ...
C. D. Green
semanticscholar +1 more source
The Replication Crisis as Market Failure [PDF]
Econometrics, 2019 This paper begins with the observation that the constrained maximisation central to model estimation and hypothesis testing may be interpreted as a kind of profit maximisation. The output of estimation is a model that maximises some measure of model fit, subject to costs that may be interpreted as the shadow price of constraints imposed on the model ...
openaire +3 more sources
By dawn or dusk—how circadian timing rewrites bacterial infection outcomes
FEBS Letters, EarlyView.The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo +2 more
wiley +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Philosophical Preconditions Guide Null Hypothesis Significance Testing in Empirical Psychology
Nordicum-MediterraneumTo mathematize is closely related to the ideal of scientific objectivity, claiming bias-free results. In this respect, mathematization may substantiate the belief that significance testing could prove or disprove a hypothesis, since it is considered bias-
Fredrik Dreyer Moe
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