Results 71 to 80 of about 2,070,021 (273)
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
The Understanding on How to Determine Sample Size in Psychological Science: Data and Simulation
Jurnal Psikologi, 2019 The lack of knowledge on how to determine sample sizes in experiments is arguably one of the main reasons underlying the replication crisis in psychological science. A survey distributed among Indonesian students and researchers concerning 1) familiarity
Wisnu Wiradhany +3 more
doaj +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Back to the test: Popper's neglected legacy in bilingual advantage research
Frontiers in Developmental PsychologyCognitive developmental science has made unprecedented progress in the last 50 years but has also seen many seminal findings fail to replicate. Adopting the bilingual advantage in children's attention control as a case study, we draw a connection between
Samuel G. Marshall, J. Bruce Morton
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Crisis, Confidence, and the Limits of Replication
ZygonThere have been calls for a program of replication in the humanities. Although usually thought of as confined to the hard sciences, replication may, under the correct conditions, be a useful tool for historians who propose an explanation of why a set of ...
Jeremy Brown
doaj +2 more sources
Publication bias and the canonization of false facts
eLife, 2016 Science is facing a “replication crisis” in which many experimental findings cannot be replicated and are likely to be false. Does this imply that many scientific facts are false as well? To find out, we explore the process by which a claim becomes fact.
Silas Boye Nissen +3 more
doaj +1 more source
Philosophy of Science and The Replicability Crisis [PDF]
Philosophy Compass, 2019 Replicability is widely taken to ground the epistemic authority of science. However, in recent years, important published findings in the social, behavioral, and biomedical sciences have failed to replicate, suggesting that these fields are facing a “replicability crisis.” For philosophers, the crisis should not be taken as bad news but as an ...
openaire +3 more sources