Results 1 to 10 of about 260,016 (217)
Genetically proxied glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide receptor pathway modulation is associated with favorable aging phenotypes: a drug-target Mendelian randomization study [PDF]
Cardiovascular DiabetologyBackground Glucagon-like peptide-1 receptor (GLP1R) agonists and dual glucose-dependent insulinotropic polypeptide receptor/glucagon-like peptide-1 receptor (GIPR/GLP1R) agonists are established treatments for diabetes and obesity, but their potential ...
Jiang Li +5 more
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Frontiers in Genetics, 2021 The strong correlation between adiposity and blood pressure (BP) might be explained in part by shared genetic risk factors. A recent study identified three nucleotide variants [rs16933812 (PAX5), rs7638110 (MRPS22), and rs9930333 (FTO)] associated with ...
Danick Goulet +4 more
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Sparse Index Tracking Portfolio with Sector Neutrality
Mathematics, 2022 As a popular passive investment strategy, a sparse index tracking strategy has advantages over a full index replication strategy because of higher liquidity and lower transaction costs.
Yuezhang Che, Shuyan Chen, Xin Liu
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The N250 event-related potential as an index of face familiarity: a replication study
Royal Society Open Science, 2021 The neural correlates of face individuation—the acquisition of memory representations for novel faces—have been studied only in coarse detail and disregarding individual differences between learners. In their seminal study, Tanaka et al.
Werner Sommer +7 more
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No relationship between researcher impact and replication effect: an analysis of five studies with 100 replications [PDF]
PeerJ, 2020 What explanation is there when teams of researchers are unable to successfully replicate already established ‘canonical’ findings? One suggestion that has been put forward, but left largely untested, is that those researchers who fail to replicate prior ...
John Protzko, Jonathan W. Schooler
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Metabolites, 2023 We aimed first to assess associations between maternal health characteristics and newborn metabolite concentrations and second to assess associations between metabolites associated with maternal health characteristics and child body mass index (BMI ...
Brittney M. Snyder +13 more
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Scientific Reports, 2021 Genomic instability (GI) influences treatment efficacy and resistance, and an accurate measure of it is lacking. Current measures of GI are based on counts of specific structural variation (SV) and mutational signatures.
Ataaillah Benhaddou +20 more
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An artemisinin-derived dimer has highly potent anti-cytomegalovirus (CMV) and anti-cancer activities. [PDF]
PLoS ONE, 2011 We recently reported that two artemisinin-derived dimers (dimer primary alcohol 606 and dimer sulfone 4-carbamate 832-4) are significantly more potent in inhibiting human cytomegalovirus (CMV) replication than artemisinin-derived monomers.
Ran He +5 more
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mSystems, 2019 Understanding ecosystem response to disturbances and identifying the most critical traits for the maintenance of ecosystem functioning are important goals for microbial community ecology.
María Victoria Pérez +4 more
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An APE1 inhibitor reveals critical roles of the redox function of APE1 in KSHV replication and pathogenic phenotypes. [PDF]
PLoS Pathogens, 2017 APE1 is a multifunctional protein with a DNA base excision repair function in its C-terminal domain and a redox activity in its N-terminal domain. The redox function of APE1 converts certain transcription factors from inactive oxidized to active reduced ...
Canrong Zhong +4 more
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