Results 131 to 140 of about 230,046 (255)

Inhibition of Replication Fork Formation and Progression: Targeting the Replication Initiation and Primosomal Proteins. [PDF]

Int J Mol Sci, 2023
Radford HM, Toft CJ, Sorenson AE, Schaeffer PM.   +3 more
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Human DNA replication initiation sites are specified epigenetically by oxidation of 5-methyl-deoxycytidine. [PDF]

Nucleic Acids Res
Krude T, Bi J, Doran R, Jones RA, Smith JC.   +4 more
europepmc   +2 more sources

PolyP inhibits CobB deacetylase triggering a regulatory coupling to prevent DNA replication initiation. [PDF]

Nucleic Acids Res
Boguszewska E, Hirsz Z, Sroka M, Bury K, Chmura W, Strzałka A, Kołodziej M, Zakrzewska-Czerwińska J, Konieczny I.   +8 more
europepmc   +1 more source

Diverse Mechanisms of Helicase Loading during DNA Replication Initiation in Bacteria. [PDF]

J Bacteriol, 2023
Blaine HC, Simmons LA, Stallings CL.
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

HIRA defines early replication initiation zones independently of their genome compartment. [PDF]

Nat Commun
Karagyozova T, Gatto A, Forest A, Quivy JP, Nunez-Vazquez R, Martí-Renom MA, Mirny LA, Almouzni G.   +7 more
europepmc   +1 more source

NatB Catalytic Subunit Depletion Disrupts DNA Replication Initiation Leading to Senescence in MEFs. [PDF]

Int J Mol Sci, 2023
Elurbide J, Carte B, Guedes J, Aldabe R.
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

DNSN-1 recruits GINS for CMG helicase assembly during DNA replication initiation in <i>Caenorhabditis elegans</i>. [PDF]

Science, 2023
Xia Y, Sonneville R, Jenkyn-Bedford M, Ji L, Alabert C, Hong Y, Yeeles JTP, Labib KPM.   +7 more
europepmc   +1 more source