Results 11 to 20 of about 3,588,418 (239)
Dynamics of replication origin over-activation [PDF]
Nature Communications, 2021 DNA replication processes are often dysregulated in cancer. Here the authors analyse DNA synthesis patterns in cancer cells undergoing partial genome re-replication to reveal that re-replication exhibits aberrant replication fork dynamics and a skewed ...
Haiqing Fu +15 more
doaj +3 more sources
Determination of human DNA replication origin position and efficiency reveals principles of initiation zone organisation. [PDF]
Nucleic Acids Res, 2022 Replication of the human genome initiates within broad zones of ~ 150 kb. The extent to which firing of individual DNA replication origins within initiation zones is spatially stochastic or localised at defined sites remains a matter of debate.
Guilbaud G +5 more
europepmc +2 more sources
Nucleosomes influence multiple steps during replication initiation [PDF]
eLife, 2017 Eukaryotic replication origin licensing, activation and timing are influenced by chromatin but a mechanistic understanding is lacking. Using reconstituted nucleosomal DNA replication assays, we assessed the impact of nucleosomes on replication initiation.
Ishara F Azmi +7 more
doaj +5 more sources
The Role of MTBP as a Replication Origin Firing Factor [PDF]
Biology, 2022 The initiation step of replication at replication origins determines when and where in the genome replication machines, replisomes, are generated. Tight control of replication initiation helps facilitate the two main tasks of genome replication, to ...
Eman Zaffar +3 more
doaj +2 more sources
Neural network and kinetic modelling of human genome replication reveal replication origin locations and strengths. [PDF]
PLoS Computational Biology, 2023 In human and other metazoans, the determinants of replication origin location and strength are still elusive. Origins are licensed in G1 phase and fired in S phase of the cell cycle, respectively.
Jean-Michel Arbona +5 more
doaj +2 more sources
Role for RNA:DNA hybrids in origin-independent replication priming in a eukaryotic system [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2015 DNA replication initiates at defined replication origins along eukaryotic chromosomes, ensuring complete genome duplication within a single S-phase. A key feature of replication origins is their ability to control the onset of DNA synthesis mediated by ...
R. Stuckey +3 more
semanticscholar +3 more sources
The Replicative Consequences of Papillomavirus E2 Protein Binding to the Origin Replication Factor ORC2. [PDF]
PLoS Pathogens, 2016 The origin recognition complex (ORC) coordinates a series of events that lead to initiation of DNA strand duplication. As a nuclear double stranded DNA plasmid, the papillomavirus (PV) genome resembles a mini-chromosome in infected cells. To initiate its
Marsha DeSmet +5 more
doaj +5 more sources
DNA replication origins in archaea [PDF]
Frontiers in Microbiology, 2014 DNA replication initiation, which starts at specific chromosomal site (known as replication origins), is the key regulatory stage of chromosome replication.
Zhenfang eWu +5 more
doaj +3 more sources
Replication origin regulation [PDF]
Nature Cell Biology, 2013 Christina Karlsson Rosenthal
semanticscholar +2 more sources
Cold Spring Harbor Perspectives in Biology, 2013 The onset of genomic DNA synthesis requires precise interactions of specialized initiator proteins with DNA at sites where the replication machinery can be loaded. These sites, defined as replication origins, are found at a few unique locations in all of the prokaryotic chromosomes examined so far.
A. C. Leonard, M. Mechali
openaire +3 more sources