Results 21 to 30 of about 3,588,418 (239)
Mechanism of replication origin melting nucleated by CMG helicase assembly. [PDF]
Nature, 2022 Lewis JS +7 more
europepmc +2 more sources
Structural mechanism of helicase loading onto replication origin DNA by ORC-Cdc6
Proceedings of the National Academy of Sciences of the United States of America, 2020 Significance The loading of the core Mcm2-7 helicase onto origin DNA is essential for the formation of replication forks and genomic stability. Here, we report two cryo-electron microscopy (cryo-EM) structures that capture helicase loader–helicase ...
Zuanning Yuan +10 more
semanticscholar +1 more source
Mcm1 Binds Replication Origins [PDF]
Journal of Biological Chemistry, 2003 Mcm1 is an essential protein required for the efficient replication of minichromosomes and the transcriptional regulation of early cell cycle genes in Saccharomyces cerevisiae. In this study, we report that Mcm1 is an abundant protein that associates globally with chromatin in a punctate pattern.
Chang, Victoria K. +5 more
openaire +3 more sources
Cell Reports, 2020 Summary: The processes that control where higher eukaryotic cells initiate DNA replication throughout the genome are not understood clearly. In metazoans, the Treslin-MTBP complex mediates critical final steps in formation of the activated replicative ...
Akiko Kumagai, William G. Dunphy
doaj +1 more source
Frontiers in Microbiology, 2021 Genome duplication is a critical event in the reproduction cycle of every cell. Because all daughter cells must inherit a complete genome, chromosome replication is tightly regulated, with multiple mechanisms focused on controlling when chromosome ...
Julia E. Grimwade, Alan C. Leonard
doaj +1 more source
An explanation for origin unwinding in eukaryotes
eLife, 2019 Twin CMG complexes are assembled head-to-head around duplex DNA at eukaryotic origins of replication. Mcm10 activates CMGs to form helicases that encircle single-strand (ss) DNA and initiate bidirectional forks.
Lance D Langston, Michael E O'Donnell
doaj +1 more source
The consequences of replicating in the wrong orientation: Bacterial chromosome duplication without an active replication origin [PDF]
, 2015 Chromosome replication is regulated in all organisms at the assembly stage of the replication machinery at specific origins. In Escherichia coli the DnaA initiator protein regulates the assembly of replication forks at oriC.
Dimude, JU +8 more
core +1 more source
Initiation of DNA replication from non-canonical sites on an origin-depleted chromosome. [PDF]
PLoS ONE, 2014 Eukaryotic DNA replication initiates from multiple sites on each chromosome called replication origins (origins). In the budding yeast Saccharomyces cerevisiae, origins are defined at discrete sites.
Naomi L Bogenschutz +2 more
doaj +1 more source
Involvement of G-quadruplex regions in mammalian replication origin activity
Nature Communications, 2019 Genome-wide studies of DNA replication origins revealed that origins preferentially associate with an Origin G-rich Repeated Element (OGRE), potentially forming G-quadruplexes (G4).
Paulina Prorok +13 more
semanticscholar +1 more source
Tel1ATM dictates the replication timing of short yeast telomeres [PDF]
, 2014 Telomerase action is temporally linked to DNA replication. Although yeast telomeres are normally late replicating, telomere shortening leads to early firing of subtelomeric DNA replication origins.
Alessandro Bianchi +4 more
core +2 more sources