Results 61 to 70 of about 1,145,720 (307)

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Roles of OB-Fold Proteins in Replication Stress

Frontiers in Cell and Developmental Biology, 2020
Accurate DNA replication is essential for maintaining genome stability. However, this stability becomes vulnerable when replication fork progression is stalled or slowed – a condition known as replication stress.
Dinh-Duc Nguyen, Eugene Y. Kim, Pau Biak Sang, Weihang Chai   +3 more
doaj   +1 more source

Identification of Epstein-Barr virus replication proteins in Burkitt’s lymphoma cells [PDF]

, 2015
The working model to describe the mechanisms used to replicate the cancer-associated virus Epstein-Barr virus (EBV) is partly derived from comparisons with other members of the Herpes virus family.
Almohammad, Rajei, Heesom, Kate, Matthews, David, Ramasubramanyan, Sharada, Rowe, Martin, Sinclair, Alison J, Sweet, Steve M M, Traylen, Chris, Zuo, Jianmin   +8 more
core   +2 more sources

Human replication protein A unfolds telomeric G-quadruplexes [PDF]

Nucleic Acids Research, 2006
G-quadruplex structures inhibit telomerase activity and must be disrupted for telomere elongation during S phase. It has been suggested that the replication protein A (RPA) could unwind and maintain single-stranded DNA in a state amenable to the binding of telomeric components.
Salas, Tonatiuh Romero, Petruseva, Irina, Lavrik, Olga, Bourdoncle, Anne, Mergny, Jean-Louis, Favre, Alain, Saintomé, Carole   +6 more
openaire   +3 more sources

Photoreactive DNA as a Tool to Study Replication Protein A Functioning in DNA Replication and Repair [PDF]

Photochemistry and Photobiology, 2020
AbstractReplication protein A (RPA), eukaryotic single‐stranded DNA‐binding protein, is a key player in multiple processes of DNA metabolism including DNA replication, recombination and DNA repair. Human RPA composed of subunits of 70‐, 32‐ and 14‐kDa binds ssDNA with high affinity and interacts specifically with multiple proteins. The RPA heterotrimer
Nadejda I. Rechkunova, Olga I. Lavrik
openaire   +2 more sources

Chl1 helicase controls replication fork progression by regulating dNTP pools

Life Science Alliance, 2022
Chl1 helicase affects RPA-dependent checkpoint activation after replication fork arrest by ensuring proper dNTP levels, thereby controlling replication fork progression under stress conditions.
Amandine Batté, Sophie C van der Horst, Mireille Tittel-Elmer, Su Ming Sun, Sushma Sharma, Jolanda van Leeuwen, Andrei Chabes, Haico van Attikum   +7 more
doaj   +1 more source

The Role for Zinc in Replication Protein A

Journal of Biological Chemistry, 2000
Heterotrimeric human single-stranded DNA (ssDNA)-binding protein, replication protein A (RPA), is a central player in DNA replication, recombination, and repair. The C terminus of the largest subunit, RPA70, contains a putative zinc-binding motif and is implicated in complex formation with two smaller subunits, RPA14 and RPA32. The C-terminal domain of
E, Bochkareva, S, Korolev, A, Bochkarev
openaire   +2 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Wss1 Promotes Replication Stress Tolerance by Degrading Histones

Cell Reports, 2020
Summary: Timely completion of DNA replication is central to accurate cell division and to the maintenance of genomic stability. However, certain DNA-protein interactions can physically impede DNA replication fork progression. Cells remove or bypass these
Karthik Maddi, Daniel Kwesi Sam, Florian Bonn, Stefan Prgomet, Eric Tulowetzke, Masato Akutsu, Jaime Lopez-Mosqueda, Ivan Dikic   +7 more
doaj   +1 more source