Results 51 to 60 of about 1,154,263 (301)

Overproduction of Escherichia coli replication proteins by the use of runaway-replication plasmids [PDF]

Journal of Bacteriology, 1983
A derivative of the runaway-replication plasmid was constructed. This plasmid, pSY343, has the gene for kanamycin resistance and single sites for EcoRI, BamHI, HindIII, KpnI, and XhoI that can be used as cloning sites without inactivating the kanamycin resistance gene or the replication genes.
S, Yasuda, T, Takagi
openaire   +2 more sources

Eukaryotic RNA binding protein hnRNPH1 suppresses influenza A virus replication through interaction with virus NS1 protein

Emerging Microbes and Infections
The NS1 protein of influenza A virus (IAV) is a multi-functional protein which can antagonize host immune system and facilitate viral replication by interacting with host factors.
Jinyu Wang, Yang Zhang, Lishan Sun, Zihan Wang, Cui Hao, Wei Wang   +5 more
doaj   +1 more source

Maintaining pH-dependent conformational flexibility of M1 is critical for efficient influenza A virus replication

Emerging Microbes and Infections, 2017
The M gene segment of influenza A virus has been shown to be a contributing factor to the high growth phenotype. However, it remains largely unknown why matrix protein 1 (M1), the major structural protein encoded by M gene, exhibits pH-dependent ...
Meng-Jung Chiang, Faik N Musayev, Martina Kosikova, Zhengshi Lin, Yamei Gao, Philip D Mosier, Bashayer Althufairi, Zhiping Ye, Qibing Zhou, Umesh R Desai, Hang Xie, Martin K Safo   +11 more
doaj   +1 more source

Human BRCA2 protein promotes RAD51 filament formation on RPA-covered single-stranded DNA. [PDF]

, 2010
BRCA2 is a tumor suppressor that functions in homologous recombination, a key genomic integrity pathway. BRCA2 interacts with RAD51, the central protein of recombination, which forms filaments on single-stranded DNA (ssDNA) to perform homology search and
Doty, Tammy, Gibson, Bryan, Heyer, Wolf-Dietrich, Liu, Jie   +3 more
core   +2 more sources

Cellular location and activity of Escherichia coli RecG proteins shed light on the function of its structurally unresolved C-terminus [PDF]

, 2014
RecG is a DNA translocase encoded by most species of bacteria. The Escherichia coli protein targets branched DNA substrates and drives the unwinding and rewinding of DNA strands.
Abd Wahab, Akeel A. Mahdi, Al-Deib, Amy L. Upton, Atkinson, Bachmann, Bernhardt, Bolt, Brendler, Briggs, Briggs, Buss, Christian J. Rudolph, Datsenko, David S. Milner, Gari, Geoffrey S. Briggs, Gregg, Gupta, Hong, Jaktaji, Jane I. Grove, Lau, Lecointe, Lesterlin, Lia, Lloyd, Lloyd, Lloyd, Machwe, Mahdi, Mahdi, Mahdi, Mahdi, Manosas, Marians, McGlynn, McGlynn, McGlynn, McGlynn, McGlynn, McGlynn, McGlynn, Michel, Parsons, Pomerantz, Ralf, Robert G. Lloyd, Rocha, Rudolph, Rudolph, Rudolph, Rudolph, Seigneur, Sharples, Shereda, Singleton, Sun, Trautinger, Tsaneva, Vincent, Waldminghaus, West, Whitby, Whitby, Whitby, Whitby, Zacharias, Zhang   +68 more
core   +2 more sources

Differential Binding of Replication Proteins across the Human c-myc Replicator [PDF]

Molecular and Cellular Biology, 2006
The binding of the prereplication complex proteins Orc1, Orc2, Mcm3, Mcm7, and Cdc6 and the novel DNA unwinding element (DUE) binding protein DUE-B to the endogenous human c-myc replicator was studied by chromatin immunoprecipitation. In G(1)-arrested HeLa cells, Mcm3, Mcm7, and DUE-B were prominent near the DUE, while Orc1 and Orc2 were least abundant
Maloy, Ghosh, Michael, Kemp, Guoqi, Liu, Marion, Ritzi, Aloys, Schepers, Michael, Leffak   +5 more
openaire   +2 more sources

Plant DNA polymerases [PDF]

, 2019
Maintenance of genome integrity is a key process in all organisms. DNA polymerases (Pols) are central players in this process as they are in charge of the faithful reproduction of the genetic information, as well as of DNA repair.
De Veylder, Lieven, Pedroza-Garcia, José Antonio, Raynaud, Cécile   +2 more
core   +3 more sources

Zika virus promotes CCN1 expression via the CaMKIIα-CREB pathway in astrocytes. [PDF]

, 2020
Zika virus (ZIKV) infection in the human central nervous system (CNS) causes Guillain-Barre syndrome, cerebellum deformity, and other diseases. Astrocytes are immune response cells in the CNS and an important component of the blood-brain barrier ...
Hu, Q, Ke, X, Li, P, Liu, Y, Mao, P, Sun, J, Tan, Z, Tang, Y, Wang, H, Zhang, W, Zhang, Y, Zheng, C, Zheng, Z   +12 more
core   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source