Results 61 to 70 of about 1,154,263 (301)
FAM111A protects replication forks from protein obstacles via its trypsin-like domain
Nature Communications, 2020 DNA-protein crosslinks represent obstacles on genomic DNA that can hamper progression of replication forks. Here, the authors reveal that FAM111A, a PCNA-interacting protein, plays part in mitigating the effect of protein obstacles on replication forks.
Yusuke Kojima +6 more
doaj +1 more source
Roles of OB-Fold Proteins in Replication Stress
Frontiers in Cell and Developmental Biology, 2020 Accurate DNA replication is essential for maintaining genome stability. However, this stability becomes vulnerable when replication fork progression is stalled or slowed – a condition known as replication stress.
Dinh-Duc Nguyen +3 more
doaj +1 more source
Chl1 helicase controls replication fork progression by regulating dNTP pools
Life Science Alliance, 2022 Chl1 helicase affects RPA-dependent checkpoint activation after replication fork arrest by ensuring proper dNTP levels, thereby controlling replication fork progression under stress conditions.
Amandine Batté +7 more
doaj +1 more source
Sterol Binding by the Tombusviral Replication Proteins Is Essential for Replication in Yeast and Plants [PDF]
Journal of Virology, 2017 ABSTRACT Membranous structures derived from various organelles are important for replication of plus-stranded RNA viruses. Although the important roles of co-opted host proteins in RNA virus replication have been appreciated for a decade, the equally important functions of cellular lipids in virus replication have been gaining ...
Kai, Xu, Peter D, Nagy
openaire +2 more sources
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
The analysis of pendolino (peo) mutants reveals differences in the fusigenic potential among Drosophila telomeres [PDF]
, 2015 Drosophila telomeres are sequence-independent structures that are maintained by transposition to chromosome ends of three specialized retroelements (HeT-A, TART and TAHRE; collectively designated as HTT) rather than telomerase activity. Fly telomeres are
Burla, Romina +8 more
core +7 more sources
Cell Reports, 2017 Srs2 is a super-family 1 helicase that promotes genome stability by dismantling toxic DNA recombination intermediates. However, the mechanisms by which Srs2 remodels or resolves recombination intermediates remain poorly understood.
Luisina De Tullio +5 more
doaj +1 more source
Murine leukemia virus (MLV) replication monitored with fluorescent proteins [PDF]
, 2006 Background: Cancer gene therapy will benefit from vectors that are able to replicate in tumor tissue and cause a bystander effect. Replication-competent murine leukemia virus (MLV) has been described to have potential as cancer therapeutics, however, MLV
Bittner, Alexandra +3 more
core
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
The Host Protein Reticulon 3.1A Is Utilized by Flaviviruses to Facilitate Membrane Remodelling
Cell Reports, 2017 Summary: Flaviviruses are enveloped, positive-sensed single-stranded RNA viruses that remodel host membranes, incorporating both viral and host factors facilitating viral replication.
Turgut E. Aktepe +4 more
doaj +1 more source