Results 31 to 40 of about 1,154,263 (301)
PLoS Pathogens, 2019 Fusogenic reoviruses encode fusion-associated small transmembrane (FAST) protein, which induces cell-cell fusion. FAST protein is the only known fusogenic protein in non-enveloped viruses, and its role in virus replication is not yet known.
Yuta Kanai +7 more
doaj +1 more source
Identification of Epstein-Barr virus replication proteins in Burkitt’s lymphoma cells [PDF]
, 2015 The working model to describe the mechanisms used to replicate the cancer-associated virus Epstein-Barr virus (EBV) is partly derived from comparisons with other members of the Herpes virus family.
Almohammad, Rajei +8 more
core +2 more sources
Creating a novel origin of replication through modulating DNA-protein interfaces. [PDF]
PLoS ONE, 2010 While the molecular mechanisms of DNA-protein specificity at the origin of replication have been determined in many model organisms, these interactions remain unknown in the majority of higher eukaryotes and numerous vertebrate viruses.
F Curtis Hewitt, R Jude Samulski
doaj +1 more source
Inhibition of hepatitis C virus RNA replication by ISG15 does not require its conjugation to protein substrates by the HERC5 E3 ligase [PDF]
, 2015 Chronic infection of the liver by hepatitis C virus (HCV) induces a range of host factors including IFN-stimulated genes such as ISG15. ISG15 functions as an antiviral factor that limits virus replication. Previous studies have suggested that ISG15 could
Bamford, Connor G.G. +3 more
core +2 more sources
Frontiers in Immunology, 2023 IntroductionGlucose Regulated Proteins/Binding protein (GRP78/Bip), a representative molecular chaperone, effectively influences and actively participates in the replication processes of many viruses.
Chenxin Han +10 more
doaj +1 more source
CTF18 interacts with replication protein A in response to replication stress
Molecular Medicine Reports, 2016 Replication stress response is a protective mechanism against defects in chromosome replication for maintaining genome integrity in eukaryotic cells. An alternative clamp loader complex termed chromosome transmission fidelity protein 18 and replication factor C (CTF18‑RFC) has been shown to act as a positive regulator of two types of replication stress
Yuta, Kaneko +3 more
openaire +3 more sources
An Alternative Form of Replication Protein A Prevents Viral Replication in Vitro [PDF]
Journal of Biological Chemistry, 2009 Replication protein A (RPA), the eukaryotic single-stranded DNA-binding complex, is essential for multiple processes in cellular DNA metabolism. The "canonical" RPA is composed of three subunits (RPA1, RPA2, and RPA3); however, there is a human homolog to the RPA2 subunit, called RPA4, that can substitute for RPA2 in complex formation.
Aaron C, Mason +5 more
openaire +2 more sources
Autophagy in HCV Replication and Protein Trafficking [PDF]
International Journal of Molecular Sciences, 2021 Autophagy is a catabolic process that is important for maintaining cellular homeostasis. It is also known to possess other functions including protein trafficking and anti-microbial activities. Hepatitis C virus (HCV) is known to co-opt cellular autophagy pathway to promote its own replication.
Ja Yeon Kim Chu, Jing-hsiung James Ou
openaire +2 more sources
UV-induced Hyperphosphorylation of Replication Protein A Depends on DNA Replication and Expression of ATM Protein [PDF]
Molecular Biology of the Cell, 2001 Exposure to DNA-damaging agents triggers signal transduction pathways that are thought to play a role in maintenance of genomic stability. A key protein in the cellular processes of nucleotide excision repair, DNA recombination, and DNA double-strand break repair is the single-stranded DNA binding protein, RPA. We showed previously that the p34 subunit
Oakley, G. G. +9 more
openaire +3 more sources
A quantitative model of the initiation of DNA replication in Saccharomyces cerevisiae predicts the effects of system perturbations. [PDF]
, 2012 BackgroundEukaryotic cell proliferation involves DNA replication, a tightly regulated process mediated by a multitude of protein factors. In budding yeast, the initiation of replication is facilitated by the heterohexameric origin recognition complex ...
DaSilva, Lance F +6 more
core +3 more sources