Results 31 to 40 of about 817,676 (313)
Coalescence of the sites of cowpea mosaic virus RNA replication into a cytopathic structure [PDF]
, 2002 Cowpea mosaic virus (CPMV) replication induces an extensive proliferation of endoplasmic reticulum (ER) membranes, leading to the formation of small membranous vesicles where viral RNA replication takes place.
Carette, J.E. +3 more
core +1 more source
PLoS Pathogens, 2019 Fusogenic reoviruses encode fusion-associated small transmembrane (FAST) protein, which induces cell-cell fusion. FAST protein is the only known fusogenic protein in non-enveloped viruses, and its role in virus replication is not yet known.
Yuta Kanai +7 more
doaj +1 more source
Creating a novel origin of replication through modulating DNA-protein interfaces. [PDF]
PLoS ONE, 2010 While the molecular mechanisms of DNA-protein specificity at the origin of replication have been determined in many model organisms, these interactions remain unknown in the majority of higher eukaryotes and numerous vertebrate viruses.
F Curtis Hewitt, R Jude Samulski
doaj +1 more source
Frontiers in Immunology, 2023 IntroductionGlucose Regulated Proteins/Binding protein (GRP78/Bip), a representative molecular chaperone, effectively influences and actively participates in the replication processes of many viruses.
Chenxin Han +10 more
doaj +1 more source
CTF18 interacts with replication protein A in response to replication stress
Molecular Medicine Reports, 2016 Replication stress response is a protective mechanism against defects in chromosome replication for maintaining genome integrity in eukaryotic cells. An alternative clamp loader complex termed chromosome transmission fidelity protein 18 and replication factor C (CTF18‑RFC) has been shown to act as a positive regulator of two types of replication stress
Yuta, Kaneko +3 more
openaire +3 more sources
An Alternative Form of Replication Protein A Prevents Viral Replication in Vitro [PDF]
Journal of Biological Chemistry, 2009 Replication protein A (RPA), the eukaryotic single-stranded DNA-binding complex, is essential for multiple processes in cellular DNA metabolism. The "canonical" RPA is composed of three subunits (RPA1, RPA2, and RPA3); however, there is a human homolog to the RPA2 subunit, called RPA4, that can substitute for RPA2 in complex formation.
Aaron C, Mason +5 more
openaire +2 more sources
Molecular Characterization of the Dbf4/Drf1-Dependent Kinase (DDK) and the DNA Replication Checkpoint Mediator Claspin in Xenopus Egg Extracts [PDF]
, 2010 The integrity of DNA replication control and checkpoint mechanisms is essential for preventing tumorigenesis. DNA replication is initiated by the S-CDK and DDK kinases which mediate the unwinding of the replication fork.
Gold, Daniel A.
core +1 more source
UV-induced Hyperphosphorylation of Replication Protein A Depends on DNA Replication and Expression of ATM Protein [PDF]
Molecular Biology of the Cell, 2001 Exposure to DNA-damaging agents triggers signal transduction pathways that are thought to play a role in maintenance of genomic stability. A key protein in the cellular processes of nucleotide excision repair, DNA recombination, and DNA double-strand break repair is the single-stranded DNA binding protein, RPA. We showed previously that the p34 subunit
Oakley, G. G. +9 more
openaire +4 more sources
Autophagy in HCV Replication and Protein Trafficking [PDF]
International Journal of Molecular Sciences, 2021 Autophagy is a catabolic process that is important for maintaining cellular homeostasis. It is also known to possess other functions including protein trafficking and anti-microbial activities. Hepatitis C virus (HCV) is known to co-opt cellular autophagy pathway to promote its own replication.
Ja Yeon Kim Chu, Jing-hsiung James Ou
openaire +2 more sources
A motif unique to the human DEAD-box protein DDX3 is important for nucleic acid binding, ATP hydrolysis, RNA/DNA unwinding and HIV-1 replication [PDF]
, 2011 DEAD-box proteins are enzymes endowed with nucleic acid-dependent ATPase, RNA translocase and unwinding activities. The human DEAD-box protein DDX3 has been shown to play important roles in tumor proliferation and viral infections.
Di Cicco, Giulia +9 more
core +1 more source