Reversal of terminal differentiation and control of DNA replication [PDF]
, 1993 DNA replication in mammalian cells occurs in discrete nuclear foci. Here we show that terminally differentiated myotubes can be induced to reenter S phase and show the same pattern of replication foci as cycling cells.
Cardoso, M. Cristina +2 more
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Virulence, 2022 DNA damage-inducible transcript 3 (DDIT3), a transcription factor, is typically involved in virus replication control. We are the first to report that DDIT3 promotes the replication of bovine viral diarrhea virus, an RNA virus, by inhibiting innate ...
Song Wang +8 more
doaj +1 more source
Passaging of a Newcastle disease virus pigeon variant in chickens results in selection of viruses with mutations in the polymerase complex enhancing virus replication and virulence [PDF]
, 2010 Some Newcastle disease virus (NDV) variants isolated from pigeons (pigeon paramyxovirus type 1; PPMV-1) do not show their full virulence potential for domestic chickens but may become virulent upon spread in these animals.
Dortmans, J.C.F.M. +3 more
core +2 more sources
Cyclophilin Inhibitors as a Novel HCV Therapy
Viruses, 2010 A critical role of Cyclophilins, mostly Cyclophilin A (CyPA), in the replication of HCV is supported by a growing body of in vitro and in vivo evidence.
Hengli Tang
doaj +1 more source
Live Cell Microscopy of Murine Polyomavirus Subnuclear Replication Centers
Viruses, 2020 During polyomavirus (PyV) infection, host proteins localize to subnuclear domains, termed viral replication centers (VRCs), to mediate viral genome replication.
Douglas K. Peters +2 more
doaj +1 more source
Evidence for two different regulatory mechanisms linking replication and segregation of vibrio cholerae chromosome II. [PDF]
PLoS Genetics, 2013 Understanding the mechanisms that coordinate replication initiation with subsequent segregation of chromosomes is an important biological problem. Here we report two replication-control mechanisms mediated by a chromosome segregation protein, ParB2 ...
Tatiana Venkova-Canova +4 more
doaj +1 more source
The Role for Zinc in Replication Protein A
Journal of Biological Chemistry, 2000 Heterotrimeric human single-stranded DNA (ssDNA)-binding protein, replication protein A (RPA), is a central player in DNA replication, recombination, and repair. The C terminus of the largest subunit, RPA70, contains a putative zinc-binding motif and is implicated in complex formation with two smaller subunits, RPA14 and RPA32. The C-terminal domain of
E, Bochkareva, S, Korolev, A, Bochkarev
openaire +2 more sources
Myxoma virus protein M029 is a dual function immunomodulator that inhibits PKR and also conscripts RHA/DHX9 to promote expanded host tropism and viral replication. [PDF]
, 2013 Myxoma virus (MYXV)-encoded protein M029 is a member of the poxvirus E3 family of dsRNA-binding proteins that antagonize the cellular interferon signaling pathways.
Chan, Winnie M +4 more
core +1 more source
Accessory Replicative Helicases and the Replication of Protein-Bound DNA
Journal of Molecular Biology, 2014 Complete, accurate duplication of the genetic material is a prerequisite for successful cell division. Achieving this accuracy is challenging since there are many barriers to replication forks that may cause failure to complete genome duplication or result in possibly catastrophic corruption of the genetic code.
Brüning, Jan-Gert +2 more
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Dissection of Functional Domains of the Human DNA Replication Protein Complex Replication Protein A [PDF]
Journal of Biological Chemistry, 1996 Replication protein A (RPA) is a mammalian single-stranded DNA binding factor essential for DNA replication, repair, and recombination. It is composed of three subunits of 70, 34, and 13 kDa (Rpa1, Rpa2, and Rpa3, respectively). Deletion mapping of the Rpa2 subunit identified the domain required for interaction with Rpa1 and Rpa3 which does not include
Y L, Lin +4 more
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