Results 21 to 30 of about 817,676 (313)

Live Cell Microscopy of Murine Polyomavirus Subnuclear Replication Centers

Viruses, 2020
During polyomavirus (PyV) infection, host proteins localize to subnuclear domains, termed viral replication centers (VRCs), to mediate viral genome replication.
Douglas K. Peters, Kimberly D. Erickson, Robert L. Garcea   +2 more
doaj   +1 more source

Cyclophilin Inhibitors as a Novel HCV Therapy

Viruses, 2010
A critical role of Cyclophilins, mostly Cyclophilin A (CyPA), in the replication of HCV is supported by a growing body of in vitro and in vivo evidence.
Hengli Tang
doaj   +1 more source

Evidence for two different regulatory mechanisms linking replication and segregation of vibrio cholerae chromosome II. [PDF]

PLoS Genetics, 2013
Understanding the mechanisms that coordinate replication initiation with subsequent segregation of chromosomes is an important biological problem. Here we report two replication-control mechanisms mediated by a chromosome segregation protein, ParB2 ...
Tatiana Venkova-Canova, Jong Hwan Baek, Peter C Fitzgerald, Melanie Blokesch, Dhruba K Chattoraj   +4 more
doaj   +1 more source

DDIT3 antagonizes innate immune response to promote bovine alphaherpesvirus 1 replication via the DDIT3-SQSTM1-STING pathway

Virulence, 2022
DNA damage-inducible transcript 3 (DDIT3), a transcription factor, is typically involved in virus replication control. We are the first to report that DDIT3 promotes the replication of bovine viral diarrhea virus, an RNA virus, by inhibiting innate ...
Song Wang, Xiaomei Ma, Jin Guo, Fangxu Li, Tianhua Chen, Wenqing Ma, Chengqiang He, Hongmei Wang, Hongbin He   +8 more
doaj   +1 more source

FMDV replicons encoding green fluorescent protein are replication competent [PDF]

, 2014
The study of replication of viruses that require high bio-secure facilities can be accomplished with less stringent containment using non-infectious 'replicon' systems. The FMDV replicon system (pT7rep) reported by Mclnerney et al. (2000) was modified by
Stonehouse, Nicola J., Tulloch, Fiona Ashley, Ryan, MD, Rowlands, DJ, Jackson, T, Pathania, Uday, Ryan, Martin D, Tuthill, Toby, Lamond, Angus I.; id_orcid, Rowlands, David J, Nicholson, J, Rowlands, David J., Tulloch, F, Luke, GA, Luke, Garry A., Nicholson, John, Lamond, Angus I., Luke, Garry A, Lamond, Angus I, Haas, Juergen, Ryan, Martin D., Tuthill, T, Hass, Juergen, Tulloch, Fiona, Luke, Garry Alec, Stonehouse, Nicola J, Jackson, Terry, Lamond, AI, Ryan, Martin Denis, Pathania, U, Haas, J, Pathania, Uday Singh, Stonehouse, NJ   +32 more
core   +1 more source

The Role for Zinc in Replication Protein A

Journal of Biological Chemistry, 2000
Heterotrimeric human single-stranded DNA (ssDNA)-binding protein, replication protein A (RPA), is a central player in DNA replication, recombination, and repair. The C terminus of the largest subunit, RPA70, contains a putative zinc-binding motif and is implicated in complex formation with two smaller subunits, RPA14 and RPA32. The C-terminal domain of
E, Bochkareva, S, Korolev, A, Bochkarev
openaire   +2 more sources

Reversal of terminal differentiation and control of DNA replication [PDF]

, 1993
DNA replication in mammalian cells occurs in discrete nuclear foci. Here we show that terminally differentiated myotubes can be induced to reenter S phase and show the same pattern of replication foci as cycling cells.
Cardoso, M. Cristina, Leonhardt, Heinrich, Nadal-Ginard, Bernardo   +2 more
core   +1 more source

Human GINS, a conserved DNA replication factor and candidate cancer marker [PDF]

, 2011
The GINS complex (a heterotetramer of Sld5, Psf1, Psf2 and Psf3) is a highly conserved DNA replication factor required for the initiation and elongation of DNA replication. GINS is believed to associate with Cdc45 and MCM proteins on replicating DNA. The

core   +2 more sources

Accessory Replicative Helicases and the Replication of Protein-Bound DNA

Journal of Molecular Biology, 2014
Complete, accurate duplication of the genetic material is a prerequisite for successful cell division. Achieving this accuracy is challenging since there are many barriers to replication forks that may cause failure to complete genome duplication or result in possibly catastrophic corruption of the genetic code.
Brüning, Jan-Gert, Howard, Jamieson L., McGlynn, Peter   +2 more
openaire   +2 more sources

Dissection of Functional Domains of the Human DNA Replication Protein Complex Replication Protein A [PDF]

Journal of Biological Chemistry, 1996
Replication protein A (RPA) is a mammalian single-stranded DNA binding factor essential for DNA replication, repair, and recombination. It is composed of three subunits of 70, 34, and 13 kDa (Rpa1, Rpa2, and Rpa3, respectively). Deletion mapping of the Rpa2 subunit identified the domain required for interaction with Rpa1 and Rpa3 which does not include
Y L, Lin, C, Chen, K F, Keshav, E, Winchester, A, Dutta   +4 more
openaire   +2 more sources