Results 11 to 20 of about 1,154,263 (301)

Replication protein A: a multifunctional protein with roles in DNA replication, repair and beyond. [PDF]

NAR Cancer, 2020
AbstractSingle-stranded DNA (ssDNA) forms continuously during DNA replication and is an important intermediate during recombination-mediated repair of damaged DNA. Replication protein A (RPA) is the major eukaryotic ssDNA-binding protein. As such, RPA protects the transiently formed ssDNA from nucleolytic degradation and serves as a physical platform ...
Dueva R, Iliakis G.
europepmc   +4 more sources

Human Replication Protein A [PDF]

Journal of Biological Chemistry, 2003
Although the mechanical aspects of the single-stranded DNA (ssDNA) binding activity of human replication protein A (RPA) have been extensively studied, only limited information is available about its interaction with other physiologically relevant DNA structures.
Pestryakov, Pavel E., Weisshart, Klaus, Schlott, Bernhard, Khodyreva, Svetlana N., Kremmer, Elisabeth, Grosse, Frank, Lavrik, Olga I., Nasheuer, Heinz-Peter   +7 more
openaire   +1 more source

Replication protein A: directing traffic at the intersection of replication and repair [PDF]

Frontiers in Bioscience, 2010
Since the initial discovery of replication protein A (RPA) as a DNA replication factor, much progress has been made on elucidating critical roles for RPA in other DNA metabolic pathways. RPA has been shown to be required for DNA replication, DNA repair, DNA recombination, and the DNA damage response pathway with roles in checkpoint activation.
Greg G, Oakley, Steve M, Patrick
openaire   +2 more sources

Capsid Proteins are Necessary for Replication of a Parvovirus [PDF]

Journal of Virology, 2020
A bstract Despite tight genetic compression, viral genomes are often organized in functional gene clusters, a modular structure that might favor their evolvability. This has greatly facilitated biotechnological developments, such as the recombinant Adeno-Associated
Labadie, Thomas, Garcia, Deborah, Mutuel, Doriane, Ogliastro, Mylène, Cambray, Guillaume   +4 more
openaire   +4 more sources

A Putative Lipid-Associating Motif in the West Nile Virus NS4A Protein Is Required for Efficient Virus Replication

Frontiers in Cell and Developmental Biology, 2021
Flavivirus replication is intimately associated with re-organized cellular membranes. These virus-induced changes in membrane architecture form three distinct membranous “organelles” that have specific functions during the flavivirus life cycle.
Andrea Mikulasova, Leah K. Gillespie, Rebecca L. Ambrose, Turgut E. Aktepe, Alice M. Trenerry, Susann Liebscher, Jason M. Mackenzie   +6 more
doaj   +1 more source

Replication Proteins and Human Disease [PDF]

Cold Spring Harbor Perspectives in Biology, 2013
In this article, we discuss the significance of DNA replication proteins in human disease. There is a broad range of mutations in genes encoding replication proteins, which result in several distinct clinical disorders that share common themes. One group of replication proteins, the MCMs, has emerged as effective biomarkers for early detection of a ...
Andrew P, Jackson, Ronald A, Laskey, Nicholas, Coleman   +2 more
openaire   +2 more sources

Chromatin Association of Replication Protein A [PDF]

Journal of Biological Chemistry, 1998
Replication protein A (RPA) is the major single strand-specific DNA-binding protein in eukaryotic cells. We have investigated the distribution of RPA in nuclei of proliferating HeLa cells and found that only one-third of the detectable RPA appeared to be bound to DNA in chromatin, whereas the remainder was free in the nucleosol.
K, Treuner, C, Eckerich, R, Knippers
openaire   +2 more sources

Are the SSB-Interacting Proteins RecO, RecG, PriA and the DnaB-Interacting Protein Rep Bound to Progressing Replication Forks in Escherichia coli? [PDF]

PLoS ONE, 2015
In all organisms several enzymes that are needed upon replication impediment are targeted to replication forks by interaction with a replication protein.
Esma Bentchikou, Carine Chagneau, Emilie Long, Mélody Matelot, Jean-François Allemand, Bénédicte Michel   +5 more
doaj   +1 more source

Diphenylpyrazoles as Replication Protein A Inhibitors [PDF]

ACS Medicinal Chemistry Letters, 2014
Replication Protein A is the primary eukaryotic ssDNA binding protein that has a central role in initiating the cellular response to DNA damage. RPA recruits multiple proteins to sites of DNA damage via the N-terminal domain of the 70 kDa subunit (RPA70N).
Alex G, Waterson, J Phillip, Kennedy, James D, Patrone, Nicholas F, Pelz, Michael D, Feldkamp, Andreas O, Frank, Bhavatarini, Vangamudi, Elaine M, Souza-Fagundes, Olivia W, Rossanese, Walter J, Chazin, Stephen W, Fesik   +10 more
openaire   +2 more sources

Cdc13 at a crossroads of telomerase action

Frontiers in Oncology, 2013
Telomere elongation by telomerase involves sequential steps that must be highly coordinated to ensure the maintenance of telomeres at a proper length. Telomerase is delivered to telomere ends, where it engages single-strand DNA end as a primer, elongates
Vincent eGELI, Dmitri echurikov, Pierre eLuciano, Yves eCorda   +3 more
doaj   +1 more source