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Dynamic elements of replication protein A at the crossroads of DNA replication, recombination, and repair [PDF]
Critical Reviews in Biochemistry and Molecular Biology, 2020 The heterotrimeric eukaryotic Replication protein A (RPA) is a master regulator of numerous DNA metabolic processes. For a long time, it has been viewed as an inert protector of ssDNA and a platform for assembly of various genome maintenance and signaling machines.
Maria Spies, Colleen Caldwell
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DNA-binding mechanism and evolution of replication protein A [PDF]
Nature Communications, 2023 Replication Protein A (RPA) is a heterotrimeric single stranded DNA-binding protein with essential roles in DNA replication, recombination and repair. Little is known about the structure of RPA in Archaea, the third domain of life.
Clément Madru +13 more
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In Vivo Targeting Replication Protein A for Cancer Therapy [PDF]
Frontiers in Oncology, 2022 Replication protein A (RPA) plays essential roles in DNA replication, repair, recombination, and the DNA damage response (DDR). Retrospective analysis of lung cancer patient data demonstrates high RPA expression as a negative prognostic biomarker for ...
Pamela S. VanderVere-Carozza +11 more
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Protein-Priming of DNA Replication [PDF]
Annual Review of Biochemistry, 1991 Peer ...
Margarita Salas
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Replication protein A: a multifunctional protein with roles in DNA replication, repair and beyond. [PDF]
NAR Cancer, 2020 AbstractSingle-stranded DNA (ssDNA) forms continuously during DNA replication and is an important intermediate during recombination-mediated repair of damaged DNA. Replication protein A (RPA) is the major eukaryotic ssDNA-binding protein. As such, RPA protects the transiently formed ssDNA from nucleolytic degradation and serves as a physical platform ...
Dueva R, Iliakis G.
europepmc +4 more sources
Microbiology Spectrum, 2021 Picornaviruses are a diverse and major cause of human disease, and their genomes replicate with intracellular membranes. The functionality of these replication organelles depends on the activities of both viral nonstructural proteins and co-opted host ...
Jia-Ying Lu +6 more
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Human Replication Protein A [PDF]
Journal of Biological Chemistry, 2003 Although the mechanical aspects of the single-stranded DNA (ssDNA) binding activity of human replication protein A (RPA) have been extensively studied, only limited information is available about its interaction with other physiologically relevant DNA structures.
Pestryakov, Pavel E. +7 more
openaire +1 more source
Microbiology Spectrum, 2023 Kaposi’s sarcoma-associated herpesvirus (KSHV) encodes six highly conserved core replication proteins essential for the viral lytic DNA synthesis, including ORF6 (single-stranded DNA-binding protein), ORF9 (DNA polymerase), ORF40/41 (primase-associated ...
Lee-Wen Chen +7 more
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Cellular PSMB4 Protein Suppresses Influenza A Virus Replication through Targeting NS1 Protein
Viruses, 2022 The nonstructural protein 1 (NS1) of influenza A virus (IAV) possesses multiple functions, such as the inhibition of the host antiviral immune responses, to facilitate viral infection. To search for cellular proteins interacting with the IAV NS1 protein,
Chee-Hing Yang +5 more
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Virus Research, 2022 Coronavirus subverts the host cell cycle to create a favorable cellular environment that enhances viral replication in host cells. Previous studies have revealed that nucleocapsid (N) protein of the coronavirus porcine epidemic diarrhea virus (PEDV ...
Qinghe Zhu +10 more
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