Results 81 to 90 of about 34,336 (231)

The S phase checkpoint promotes the Smc5/6 complex dependent SUMOylation of Pol2, the catalytic subunit of DNA polymerase ε [PDF]

, 2019
Replication fork stalling and accumulation of single-stranded DNA trigger the S phase checkpoint, a signalling cascade that, in budding yeast, leads to the activation of the Rad53 kinase.
A Gambus, A Gambus, A Jacome, A Kegel, A McAleenan, A, C Simon, A. Alcasabas A, AA Armstrong, Alicja Winczura, B Pardo, B Pfander, C Alabert, C Denison, C Horigome, C Janke, C Zhou, CA Cremona, CP Albuquerque, CP Albuquerque, CS Wu, CS Wu, D Branzei, D Menolfi, D, J Netz, D, L Swaney, D. Sekedat M, David P. Toczyski, DB Grabarczyk, DD Wykoff, DE Bustard, E Kitamura, E Papouli, EA Andrews, ES Johnson, ES Johnson, F Villa, G Beauclair, G Can, G De Piccoli, G De Piccoli, GI Karras, Giacomo De Piccoli, GL Moldovan, H Araki, H Gaillard, H Gan, H Okimoto, HB Lindroos, I Gibbs-Seymour, I Psakhye, I Psakhye, IA Hendriks, J Bacal, J Prudden, J Sollier, J Ter Beek, J Torres-Rosell, J Torres-Rosell, J, T Yeeles, J. García-Rodríguez L, JA Cobb, JA Wohlschlegel, JC Randell, JC Zhou, JM Sogo, JN Bonner, JR Gareau, K Jeppsson, K Labib, K Labib, K Nishimura, KJ Simpson-Lavy, KK Carlborg, L Crabbé, L Wei, LE Hang, M Bando, M Bermúdez-López, M Esteras, M Foiani, M Fottner, M Giannattasio, M Grenon, M Hogg, M Hogg, M Huang, M Knop, M Lopes, M Maric, M Sacher, M Tittel-Elmer, M, K Zeman, MB Smolka, Michael H. Tatham, N Varejão, N Wu, N Zilio, O Kerscher, P Kotsantis, P Zegerman, PR Potts, PR Potts, PY Ohouo, R Dua, R Geiss-Friedlander, R, C. Heller, Ronald T. Hay, Rowin Appanah, S Bergink, S Hiraga, S Mattarocci, S Munk, S Tanaka, SH Chen, SJ Szyjka, SP Bell, T Kubota, T Makhnevych, T Ryu, T Usui, TA Weinert, X Zhao, X Zhao, YJ Sheu, Z Zhou   +124 more
core   +3 more sources

Canonical and non‐canonical functions of proteins regulating mitochondrial dynamics in mammalian physiology

The Journal of Physiology, EarlyView.
Abstract figure legend Mitochondria are highly dynamic organelles that continuously remodel their architecture through coordinated cycles of fusion and fission. This review examines the four key GTPases that orchestrate mitochondrial dynamics in mammals: MFN1, MFN2, OPA1, and DRP1.
Rémi Chaney, Vincent Marcangeli, Krystel Desjardins, Shima Taherkhani, Gilles Gouspillou   +4 more
wiley   +1 more source

TTF2 drives mitotic replisome disassembly and MiDAS by coupling the TRAIP ubiquitin ligase to Polε

bioRxiv
Mammalian cells frequently enter mitosis before DNA replication has finished, necessitating the rapid processing of replication forks to facilitate chromosome segregation.
Ryo Fujisawa, K. P. Labib
semanticscholar   +1 more source

Fifty Years of Natural Killer Cells: Milestones and Future Horizons

Scandinavian Journal of Immunology, Volume 103, Issue 2, February 2026.
To mark 50 years of NK cell research, a 2025 Karolinska symposium traced discoveries from spontaneous cytotoxicity and “missing self” recognition to receptor biology, cellular diversity, and translational advances, highlighting NK cells’ evolution into modern immunotherapy.
Andreas Lundqvist, Arnika K. Wagner, Benedict J. Chambers, Carin I. M. Dahlberg, Jonas Sundbäck, Angelica Cuapio, Evren Alici, Hans‐Gustaf Ljunggren   +7 more
wiley   +1 more source

Alpers disease mutations in human mitochondrial DNA polymerase cause catalytic defects in mitochondrial DNA replication by distinct mechanisms

Frontiers in Genetics, 2015
The human mitochondrial DNA polymerase gamma (Pol-γ) is nuclearly encoded and is responsible for the replication and repair of the mitochondrial genome. Mutations S305R and P1073L in the POLG gene have been reported to be associated with early-childhood ...
Yufeng eQian, Jessica eZiehr, Kenneth eJohnson   +2 more
doaj   +1 more source

TTF2 promotes replisome eviction from stalled forks in mitosis

bioRxiv
When cells enter mitosis with under-replicated DNA, sister chromosome segregation is compromised, which can lead to massive genome instability. The replisome-associated E3 ubiquitin ligase TRAIP mitigates this threat by ubiquitylating the CMG helicase in
Geylani Can, M. Shyian, A. Krishnamoorthy, Yang Lim, R. A. Wu, Manal S. Zaher, Markus Raschle, Johannes C. Walter, David Pellman   +8 more
semanticscholar   +1 more source

Metformin Restores Mitochondrial Function and Neurogenesis in POLG Patient‐Derived Brain Organoids

Advanced Science, Volume 13, Issue 4, 19 January 2026.
Patient‐derived POLG‐mutant cortical organoids reveal neuronal subtype‐specific mitochondrial and synaptic defects, with dopaminergic neurons most affected. Metformin treatment restores neuronal identity, mitochondrial function, and excitability, increased mtDNA maintenance, and reprogrammed metabolism via TCA and redox pathways.
Zhuoyuan Zhang, Tsering Yangzom, Ning Lu, Shenglong Deng, Xianglu Xiao, Guang Yang, Kristina Xiao Liang   +6 more
wiley   +1 more source

Role of the ubiquitin-selective CDC-48/UFD-1/NPL-4 chaperone in DNA replication [PDF]

, 2012
Faithful transmission of genomic information requires tight spatiotemporal regulation of DNA replication factors. Posttranslational modifications, such as ubiquitylation, constitute a fast and effective mechanism to control such complex protein function.
Franz, André
core  

Pif1-Family helicases support fork convergence during DNA replication termination in eukaryotes [PDF]

, 2019
The convergence of two DNA replication forks creates unique problems during DNA replication termination. In E. coli and SV40, the release of torsional strain by type II topoisomerases is critical for converging replisomes to complete DNA synthesis, but ...
Baxter, Jonathan, Deegan, Tom D, Labib, Karim P M, Ortiz Bazán, María Ángeles, Yeeles, Joseph T P   +4 more
core   +6 more sources

Architecture of the Saccharomyces cerevisiae Replisome [PDF]

, 2017
Eukaryotic replication proteins are highly conserved, and thus study of Saccharomyces cerevisiae replication can inform about this central process in higher eukaryotes including humans. The S. cerevisiae replisome is a large and dynamic assembly comprised of ~50 proteins.
Lin, Bai, Zuanning, Yuan, Jingchuan, Sun, Roxana, Georgescu, Michael E, O'Donnell, Huilin, Li   +5 more
openaire   +2 more sources