Results 11 to 20 of about 41,808 (246)

Sarcoplasmic Reticulum Calcium Release Is Required for Arrhythmogenesis in the Mouse

Frontiers in Physiology, 2021
Dysfunctional sarcoplasmic reticulum Ca2+ handling is commonly observed in heart failure, and thought to contribute to arrhythmogenesis through several mechanisms. Some time ago we developed a cardiomyocyte-specific inducible SERCA2 knockout mouse, which
Andrew G. Edwards, Andrew G. Edwards, Halvor Mørk, Mathis K. Stokke, Mathis K. Stokke, Mathis K. Stokke, David B. Lipsett, Ivar Sjaastad, Ivar Sjaastad, Sylvain Richard, Ole M. Sejersted, William E. Louch, William E. Louch   +12 more
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Role of the Purkinje-Muscle Junction on the Ventricular Repolarization Heterogeneity in the Healthy and Ischemic Ovine Ventricular Myocardium

Frontiers in Physiology, 2018
Alteration of action potential duration (APD) heterogeneity contributes to arrhythmogenesis. Purkinje-muscle junctions (PMJs) present differential electrophysiological properties including longer APD.
Marine E. Martinez, Marine E. Martinez, Marine E. Martinez, Richard D. Walton, Richard D. Walton, Richard D. Walton, Jason D. Bayer, Jason D. Bayer, Michel Haïssaguerre, Michel Haïssaguerre, Michel Haïssaguerre, Michel Haïssaguerre, Edward J. Vigmond, Edward J. Vigmond, Mélèze Hocini, Mélèze Hocini, Mélèze Hocini, Mélèze Hocini, Olivier Bernus, Olivier Bernus, Olivier Bernus   +20 more
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Temporal Variability in Electrocardiographic Indices in Subjects With Brugada Patterns

Frontiers in Physiology, 2020
IntroductionPatients with Brugada electrocardiographic (ECG) patterns have differing levels of arrhythmic risk. We hypothesized that temporal variations in certain ECG markers may provide additional value for risk stratification.
Sharen Lee, Jiandong Zhou, Tong Liu, Konstantinos P. Letsas, Sandeep S. Hothi, Vassilios S. Vassiliou, Guoliang Li, Adrian Baranchuk, Raymond W. Sy, Raymond W. Sy, Dong Chang, Qingpeng Zhang, Gary Tse, Gary Tse   +13 more
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Electrocardiographic markers of myocardial conduction and repolarization in Boxer dogs [PDF]

Pesquisa Veterinária Brasileira, 2020
: Electrocardiographic markers have been used in people to classify arrhythmogenic risk. The aims of this study were to investigate electrocardiographic markers of conduction and repolarization in Boxers and non-Boxer dogs, and compare such findings ...
Elizabeth Regina Carvalho, Evandro Zacché, Michelli Fenerich, Aparecido Antônio Camacho, Julio P. Santos, Marlos G. Sousa   +5 more
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Changes of repolarization parameters after left bundle branch area pacing and the association with echocardiographic response in heart failure patients

Frontiers in Physiology, 2022
Background: Left bundle branch area pacing (LBBAP) has become a safe and effective option for heart failure (HF) patients indicated for cardiac resynchronization therapy (CRT) and/or ventricular pacing, yet the response rate was only 70%.
Yao Li, Wenzhao Lu, Qingyun Hu, Chendi Cheng, Jinxuan Lin, Yu’an Zhou, Ruohan Chen, Yan Dai, Keping Chen, Shu Zhang   +9 more
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Early screening of hypertension and cardiac dysautonomia in each hypertensive is needed-inference from a study of QTc interval in Gujarat, India

International Journal of Preventive Medicine, 2018
Background: Hypertension (HTN) is linked to cardiac dysautonomia that can end up as life-threatening arrhythmias. The same can be screened by simple electrocardiogram (ECG)-based QTc (QT corrected for heart rate) interval which indicates repolarization ...
Jayesh Dalpatbhai Solanki, Bhakti P Gadhavi, Amit H Makwana, Hemant B Mehta, Chinmay J Shah, Pradnya A Gokhale   +5 more
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Incorporating Latent Variables Using Nonnegative Matrix Factorization Improves Risk Stratification in Brugada Syndrome

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020
Background A combination of clinical and electrocardiographic risk factors is used for risk stratification in Brugada syndrome. In this study, we tested the hypothesis that the incorporation of latent variables between variables using nonnegative matrix ...
Gary Tse, Jiandong Zhou, Sharen Lee, Tong Liu, George Bazoukis, Panagiotis Mililis, Ian C. K. Wong, Cheng Chen, Yunlong Xia, Tsukasa Kamakura, Takeshi Aiba, Kengo Kusano, Qingpeng Zhang, Konstantinos P. Letsas   +13 more
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Electrocardiographic Imaging of Repolarization Abnormalities

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background Dispersion and gradients in repolarization have been associated with life‐threatening arrhythmias, but are difficult to quantify precisely from surface electrocardiography.
Laura R. Bear, Matthijs Cluitmans, Emma Abell, Julien Rogier, Louis Labrousse, Leo K. Cheng, Ian LeGrice, Nigel Lever, Gregory B. Sands, Bruce Smaill, Michel Haïssaguerre, Olivier Bernus, Ruben Coronel, Rémi Dubois   +13 more
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Ionic current changes underlying action potential repolarization responses to physiological pacing and adrenergic stimulation in adult rat ventricular myocytes

Physiological Reports, 2023
This study aimed to simulate ventricular responses to elevations in myocyte pacing and adrenergic stimulation using a novel electrophysiological rat model and investigate ion channel responses underlying action potential (AP) modulations.
Luke A. Howlett, Harley Stevenson‐Cocks, Michael A. Colman, Matthew K. Lancaster, Alan P. Benson   +4 more
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Increased Beat-to-Beat Variability of T-Wave Heterogeneity Measured From Standard 12-Lead Electrocardiogram Is Associated With Sudden Cardiac Death: A Case–Control Study

Frontiers in Physiology, 2020
IntroductionThe prognostic significance of beat-to-beat variability of spatial heterogeneity of repolarization measured from standard 12-lead ECG is not well-understood.MethodsWe measured the short-term variability of repolarization parameters, such as T-
Jenni J. Hekkanen, Tuomas V. Kenttä, Mira Anette E. Haukilahti, Janne T. Rahola, Lauri Holmström, Juha Vähätalo, Mikko P. Tulppo, Antti M. Kiviniemi, Lasse Pakanen, Lasse Pakanen, Olavi H. Ukkola, M. Juhani Junttila, Heikki V. Huikuri, Juha S. Perkiömäki   +13 more
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