Results 11 to 20 of about 105,162 (327)

Electrocardiographic Imaging of Repolarization Abnormalities

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background Dispersion and gradients in repolarization have been associated with life‐threatening arrhythmias, but are difficult to quantify precisely from surface electrocardiography.
Laura R. Bear, Matthijs Cluitmans, Emma Abell, Julien Rogier, Louis Labrousse, Leo K. Cheng, Ian LeGrice, Nigel Lever, Gregory B. Sands, Bruce Smaill, Michel Haïssaguerre, Olivier Bernus, Ruben Coronel, Rémi Dubois   +13 more
doaj   +2 more sources

The Electrogenic Na+/K+ Pump Is a Key Determinant of Repolarization Abnormality Susceptibility in Human Ventricular Cardiomyocytes: A Population-Based Simulation Study

Frontiers in Physiology, 2017
Background: Cellular repolarization abnormalities occur unpredictably due to disease and drug effects, and can occur even in cardiomyocytes that exhibit normal action potentials (AP) under control conditions.
Oliver J. Britton, Alfonso Bueno-Orovio, László Virág, András Varró, Blanca Rodriguez   +4 more
doaj   +2 more sources

Reduction in Kv Current Enhances the Temporal Dispersion of the Action Potential in Diabetic Myocytes: Insights From a Novel Repolarization Algorithm

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016
BackgroundDiabetes is associated with prolongation of the QT interval of the electrocardiogram and enhanced dispersion of ventricular repolarization, factors that, together with atherosclerosis and myocardial ischemia, may promote the occurrence of ...
Marianna Meo, Olivier Meste, Sergio Signore, Andrea Sorrentino, Antonio Cannata, Yu Zhou, Alex Matsuda, Marco Luciani, Ramaswamy Kannappan, Polina Goichberg, Annarosa Leri, Piero Anversa, Marcello Rota   +12 more
doaj   +2 more sources

Early Repolarization Syndrome: Diagnostic and Therapeutic Approach

Frontiers in Cardiovascular Medicine, 2018
An early repolarization pattern can be observed in 1% up to 13% of the overall population. Whereas, this pattern was associated with a benign outcome for many years, several more recent studies demonstrated an association between early repolarization and
Felix Bourier, Arnaud Denis, Arnaud Denis, Ghassen Cheniti, Ghassen Cheniti, Anna Lam, Konstantinos Vlachos, Masateru Takigawa, Masateru Takigawa, Takeshi Kitamura, Antonio Frontera, Josselin Duchateau, Josselin Duchateau, Josselin Duchateau, Thomas Pambrun, Thomas Pambrun, Nicolas Klotz, Nicolas Klotz, Nicolas Derval, Nicolas Derval, Frédéric Sacher, Frédéric Sacher, Frédéric Sacher, Pierre Jais, Pierre Jais, Pierre Jais, Michel Haissaguerre, Michel Haissaguerre, Michel Haissaguerre, Mélèze Hocini, Mélèze Hocini, Mélèze Hocini   +31 more
doaj   +2 more sources

Macrophage Repolarization as a Therapeutic Strategy for Osteosarcoma

International Journal of Molecular Sciences, 2023
Macrophages are versatile immune cells and can adapt to both external stimuli and their surrounding environment. Macrophages are categorized into two major categories; M1 macrophages release pro-inflammatory cytokines and produce protective responses ...
N. Anand, K. H. Peh, J. Kolesar
semanticscholar   +1 more source

Heterogeneous repolarization creates ventricular tachycardia circuits in healed myocardial infarction scar

Nature Communications, 2022
Arrhythmias originating in scarred ventricular myocardium are a major cause of death, but the underlying mechanism allowing these rhythms to exist remains unknown.
Kamilla Kelemen, I. Greener, X. Wan, Shankar Parajuli, J. K. Donahue   +4 more
semanticscholar   +1 more source

Noninvasive detection of spatiotemporal activation-repolarization interactions that prime idiopathic ventricular fibrillation

Science Translational Medicine, 2021
Description Premature beats originating in clinically concealed areas of local early repolarization promote ventricular arrhythmias and sudden cardiac arrest.
Matthijs J. M. Cluitmans, L. Bear, U. Nguyên, B. van Rees, J. Stoks, R. T. ter Bekke, C. Mihl, J. Heijman, K. D. Lau, E. Vigmond, J. Bayer, C. Belterman, E. Abell, L. Labrousse, J. Rogier, O. Bernus, M. Haïssaguerre, R. Hassink, R. Dubois, R. Coronel, P. Volders   +20 more
semanticscholar   +1 more source

M2-Like Tumor-Associated Macrophage-Targeted Codelivery of STAT6 Inhibitor and IKKβ siRNA Induces M2-to-M1 Repolarization for Cancer Immunotherapy with Low Immune Side Effects

ACS Central Science, 2020
Tumor-associated macrophages (TAMs) usually display the tumor-promoting M2 phenotype rather than the tumoricidal M1 phenotype. Thus, M2-to-M1 repolarization of TAMs has emerged as a promising strategy for tumor immunotherapy nowadays.
Hong Xiao, Yu Guo, Bo Li, Xiaoxia Li, Yong Wang, Shisong Han, Du Cheng, X. Shuai   +7 more
semanticscholar   +1 more source

Sarcoplasmic Reticulum Calcium Release Is Required for Arrhythmogenesis in the Mouse

Frontiers in Physiology, 2021
Dysfunctional sarcoplasmic reticulum Ca2+ handling is commonly observed in heart failure, and thought to contribute to arrhythmogenesis through several mechanisms. Some time ago we developed a cardiomyocyte-specific inducible SERCA2 knockout mouse, which
Andrew G. Edwards, Andrew G. Edwards, Halvor Mørk, Mathis K. Stokke, Mathis K. Stokke, Mathis K. Stokke, David B. Lipsett, Ivar Sjaastad, Ivar Sjaastad, Sylvain Richard, Ole M. Sejersted, William E. Louch, William E. Louch   +12 more
doaj   +1 more source

The Effect of Emotional Valence on Ventricular Repolarization Dynamics Is Mediated by Heart Rate Variability: A Study of QT Variability and Music-Induced Emotions

Frontiers in Physiology, 2019
BackgroundEmotions can affect cardiac activity, but their impact on ventricular repolarization variability, an important parameter providing information about cardiac risk and autonomic nervous system activity, is unknown. The beat-to-beat variability of
Michele Orini, Michele Orini, Faez Al-Amodi, Stefan Koelsch, Raquel Bailón, Raquel Bailón   +5 more
doaj   +1 more source