Results 21 to 30 of about 41,808 (246)

Comparison of Electrocardiographic Repolarization Patterns between Hypogonad Males and Normal Subjects

Annals of Noninvasive Electrocardiology, 2003
Background: There is a significant difference in repolarization on the surface ECG between men and women. The effect of testosterone on repolarization of myocardium may provide a basis for the physiological and pathophysiological importance of these ...
Ata Kirilmaz, Erol Bolu, Fethi Kilicaslan, Kursad Erinc, Mehmet Uzun, Ersoy Isik, Metin Ozata, Caglayan Ozdemir, Ertan Demirtas   +8 more
doaj   +1 more source

Arrhythmogenic Mechanisms in Hypokalaemia: Insights From Pre-clinical Models

Frontiers in Cardiovascular Medicine, 2021
Potassium is the predominant intracellular cation, with its extracellular concentrations maintained between 3. 5 and 5 mM. Among the different potassium disorders, hypokalaemia is a common clinical condition that increases the risk of life-threatening ...
Gary Tse, Gary Tse, Ka Hou Christien Li, Chloe Kwong Yee Cheung, Konstantinos P. Letsas, Aishwarya Bhardwaj, Abhishek C. Sawant, Tong Liu, Gan-Xin Yan, Henggui Zhang, Kamalan Jeevaratnam, Nazish Sayed, Nazish Sayed, Nazish Sayed, Shuk Han Cheng, Shuk Han Cheng, Shuk Han Cheng, Wing Tak Wong   +17 more
doaj   +1 more source

Repolarization Reserve [PDF]

Circulation, 2008
A drug dose (and con-centration) that produces minimal QT prolongation in onepatient may, in an apparently indistinguishable subject, pro-duce marked QT prolongation and torsade de pointes. Thisvariability in response to an exogenous stressor is paralleledby variability in the extent to which a given mutation in thecongenital long-QT syndrome prolongs ...
openaire   +2 more sources

Discovery of Hydrazineyl Amide Derivative of Pseudolaric Acid B for Reprogramming Tumor-Associated Macrophages Against Tumor Growth

Molecules
Tumor-associated macrophages (TAMs) are pivotal for tumor development and progression. Reprogramming the M2-like pro-tumoral behavior of TAMs towards the M1-like anti-tumor phenotype to unleash their potential against tumors has become one of the most ...
Xia Peng, Siqi Yu, Lin Xu, Qinghua Wang, Lin Yang, Yi Su, Zhirou Xiong, Mengjie Shao, Meiyu Geng, Ao Zhang, Lei Zhang, Jing Ai, Chunyong Ding   +12 more
doaj   +1 more source

Electrophysiology Models for End-Stage Renal Disease Maladaptations That Promote Asystole

Reviews in Cardiovascular Medicine
Many patients with chronic renal impairment experience cardiac comorbidities throughout their lives, and the incidence of electrophysiological demise for patients with terminal renal impairment requiring renal replacement therapy is higher than in ...
Ikeotunye Royal Chinyere
doaj   +1 more source

Angiotensinogen and Angiotensin II Type 1 Receptor Gene Polymorphisms and Changes in Repolarization Parameters in Elderly Chinese: A 4-Year Follow-up Study

Kaohsiung Journal of Medical Sciences, 2008
Ventricular repolarization abnormality plays a crucial role in cardiac arrhythmia. Polymorphisms in renin—angiotensin system genes are associated with occurrence of ventricular arrhythmia. We previously demonstrated that subjects carrying the angiotensin
Ya-Ting Lee, Herng-Chia Chiu, Ho-Ming Su, Wen-Chol Voon, Tsung-Hsien Lin, Wen-Ter Lai, Sheng-Hsiung Sheu   +6 more
doaj   +1 more source

Depolarization and repolarization dynamics after His‐bundle pacing: Comparison with right ventricular pacing and native ventricular conduction

Annals of Noninvasive Electrocardiology, 2022
Background The current study aimed to evaluate changes in electrical depolarization and repolarization parameters after His‐bundle pacing (HBP) compared with right ventricular pacing (RVP) and its association with ventricular arrhythmia (VA).
Satoshi Yanagisawa, Yasuya Inden, Ryo Watanabe, Naoki Tsurumi, Noriyuki Suzuki, Toshifumi Nakagomi, Masafumi Shimojo, Takashi Okajima, Shuro Riku, Koichi Furui, Kazumasa Suga, Rei Shibata, Toyoaki Murohara   +12 more
doaj   +1 more source

Temporal variability of T‐wave morphology and risk of sudden cardiac death in patients with coronary artery disease

Annals of Noninvasive Electrocardiology, 2021
Background The possible relationship between temporal variability of electrocardiographic spatial heterogeneity of repolarization and the risk of sudden cardiac death (SCD) in patients with coronary artery disease (CAD) is not completely understood ...
Janne T. Rahola, Antti M. Kiviniemi, Olavi H. Ukkola, Mikko P. Tulppo, M. Juhani Junttila, Heikki V. Huikuri, Tuomas V. Kenttä, Juha S. Perkiömäki   +7 more
doaj   +1 more source

Repolarization Alternans [PDF]

Circulation Research, 2000
The appearance of electrocardiographic T-wave alternans with elevated heart rate or metabolic insult has been observed for nearly a century.1 Macroscopic T-wave alternans is often noted as a harbinger of sudden arrhythmic death.2 Efforts to quantify the magnitude of more subtle repolarization alternans and relate these measurements to arrhythmia ...
openaire   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source