Results 41 to 50 of about 105,162 (327)

Can non‐clinical repolarization assays predict the results of clinical thorough QT studies? Results from a research consortium

British Journal of Pharmacology, 2018
Translation of non‐clinical markers of delayed ventricular repolarization to clinical prolongation of the QT interval corrected for heart rate (QTc) (a biomarker for torsades de pointes proarrhythmia) remains an issue in drug discovery and regulatory ...
Eunjung Park, G. Gintant, D. Bi, Devi Kozeli, S. Pettit, Jennifer B Pierson, M. Skinner, J. Willard, Todd A. Wisialowski, J. Koerner, J. Valentin   +10 more
semanticscholar   +1 more source

Dynamics of conduction blocks in a model of paced cardiac tissue [PDF]

, 2005
We study numerically the dynamics of conduction blocks using a detailed electrophysiological model. We find that this dynamics depends critically on the size of the paced region.
C. H. Luo, C. H. Luo, Hervé Henry, J. M. Pastore, M. Guevara, M. Pressler, Wouter-Jan Rappel, Z. Qu   +7 more
core   +1 more source

Discovery of Hydrazineyl Amide Derivative of Pseudolaric Acid B for Reprogramming Tumor-Associated Macrophages Against Tumor Growth

Molecules
Tumor-associated macrophages (TAMs) are pivotal for tumor development and progression. Reprogramming the M2-like pro-tumoral behavior of TAMs towards the M1-like anti-tumor phenotype to unleash their potential against tumors has become one of the most ...
Xia Peng, Siqi Yu, Lin Xu, Qinghua Wang, Lin Yang, Yi Su, Zhirou Xiong, Mengjie Shao, Meiyu Geng, Ao Zhang, Lei Zhang, Jing Ai, Chunyong Ding   +12 more
doaj   +1 more source

Angiotensinogen and Angiotensin II Type 1 Receptor Gene Polymorphisms and Changes in Repolarization Parameters in Elderly Chinese: A 4-Year Follow-up Study

Kaohsiung Journal of Medical Sciences, 2008
Ventricular repolarization abnormality plays a crucial role in cardiac arrhythmia. Polymorphisms in renin—angiotensin system genes are associated with occurrence of ventricular arrhythmia. We previously demonstrated that subjects carrying the angiotensin
Ya-Ting Lee, Herng-Chia Chiu, Ho-Ming Su, Wen-Chol Voon, Tsung-Hsien Lin, Wen-Ter Lai, Sheng-Hsiung Sheu   +6 more
doaj   +1 more source

Electrophysiology Models for End-Stage Renal Disease Maladaptations That Promote Asystole

Reviews in Cardiovascular Medicine
Many patients with chronic renal impairment experience cardiac comorbidities throughout their lives, and the incidence of electrophysiological demise for patients with terminal renal impairment requiring renal replacement therapy is higher than in ...
Ikeotunye Royal Chinyere
doaj   +1 more source

Percutaneous pulmonary valve implantation alters electrophysiologic substrate [PDF]

, 2016
BACKGROUND: Percutaneous pulmonary valve implantation (PPVI) is first‐line therapy for some congenital heart disease patients with right ventricular outflow tract dysfunction.
Avari Silva, Jennifer N, Balzer, David T, Nguyen, Hoang H, Nicolas, Ramzi, Shahanavaz, Shabana, Van Hare, George F   +5 more
core   +2 more sources

Arrhythmogenic Mechanisms in Hypokalaemia: Insights From Pre-clinical Models

Frontiers in Cardiovascular Medicine, 2021
Potassium is the predominant intracellular cation, with its extracellular concentrations maintained between 3. 5 and 5 mM. Among the different potassium disorders, hypokalaemia is a common clinical condition that increases the risk of life-threatening ...
Gary Tse, Gary Tse, Ka Hou Christien Li, Chloe Kwong Yee Cheung, Konstantinos P. Letsas, Aishwarya Bhardwaj, Abhishek C. Sawant, Tong Liu, Gan-Xin Yan, Henggui Zhang, Kamalan Jeevaratnam, Nazish Sayed, Nazish Sayed, Nazish Sayed, Shuk Han Cheng, Shuk Han Cheng, Shuk Han Cheng, Wing Tak Wong   +17 more
doaj   +1 more source

TRPV4 Contributes to Resting Membrane Potential in Retinal Müller Cells: Implications in Cell Volume Regulation [PDF]

, 2017
Neural activity alters osmotic gradients favoring cell swelling in retinal Müller cells. This swelling is followed by a regulatory volume decrease (RVD), partially mediated by an efflux of KCl and water. The transient receptor potential channel 4 (TRPV4),
Capurro, Claudia Graciela, Di Giusto, Gisela, Fernández, Juan, Ford, Paula, Kalstein, Maia, Netti, Vanina Alejandra, Pizzoni, Alejandro, Rivarola, Valeria   +7 more
core   +1 more source

Electrocardiographic manifestation of cardiac repolarization dispersion [PDF]

, 2019
Alterations of repolarization heterogeneity in the heart have been established as anAlterations of repolarization heterogeneity in the heart have been established as ...
Sedova Ksenia
core  

Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes

Advanced Functional Materials, EarlyView.
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth, Neal I. Callaghan, Locke Davenport Huyer   +2 more
wiley   +1 more source