Results 41 to 50 of about 100,632 (325)

Repolarization Reserve [PDF]

Circulation, 2008
A drug dose (and con-centration) that produces minimal QT prolongation in onepatient may, in an apparently indistinguishable subject, pro-duce marked QT prolongation and torsade de pointes. Thisvariability in response to an exogenous stressor is paralleledby variability in the extent to which a given mutation in thecongenital long-QT syndrome prolongs ...
openaire   +2 more sources

Arrhythmogenic Mechanisms in Hypokalaemia: Insights From Pre-clinical Models

Frontiers in Cardiovascular Medicine, 2021
Potassium is the predominant intracellular cation, with its extracellular concentrations maintained between 3. 5 and 5 mM. Among the different potassium disorders, hypokalaemia is a common clinical condition that increases the risk of life-threatening ...
Gary Tse, Gary Tse, Ka Hou Christien Li, Chloe Kwong Yee Cheung, Konstantinos P. Letsas, Aishwarya Bhardwaj, Abhishek C. Sawant, Tong Liu, Gan-Xin Yan, Henggui Zhang, Kamalan Jeevaratnam, Nazish Sayed, Nazish Sayed, Nazish Sayed, Shuk Han Cheng, Shuk Han Cheng, Shuk Han Cheng, Wing Tak Wong   +17 more
doaj   +1 more source

Can non‐clinical repolarization assays predict the results of clinical thorough QT studies? Results from a research consortium

British Journal of Pharmacology, 2018
Translation of non‐clinical markers of delayed ventricular repolarization to clinical prolongation of the QT interval corrected for heart rate (QTc) (a biomarker for torsades de pointes proarrhythmia) remains an issue in drug discovery and regulatory ...
Eunjung Park, G. Gintant, D. Bi, Devi Kozeli, S. Pettit, Jennifer B Pierson, M. Skinner, J. Willard, Todd A. Wisialowski, J. Koerner, J. Valentin   +10 more
semanticscholar   +1 more source

TRPV4 Contributes to Resting Membrane Potential in Retinal Müller Cells: Implications in Cell Volume Regulation [PDF]

, 2017
Neural activity alters osmotic gradients favoring cell swelling in retinal Müller cells. This swelling is followed by a regulatory volume decrease (RVD), partially mediated by an efflux of KCl and water. The transient receptor potential channel 4 (TRPV4),
Capurro, Claudia Graciela, Di Giusto, Gisela, Fernández, Juan, Ford, Paula, Kalstein, Maia, Netti, Vanina Alejandra, Pizzoni, Alejandro, Rivarola, Valeria   +7 more
core   +1 more source

Discovery of Hydrazineyl Amide Derivative of Pseudolaric Acid B for Reprogramming Tumor-Associated Macrophages Against Tumor Growth

Molecules
Tumor-associated macrophages (TAMs) are pivotal for tumor development and progression. Reprogramming the M2-like pro-tumoral behavior of TAMs towards the M1-like anti-tumor phenotype to unleash their potential against tumors has become one of the most ...
Xia Peng, Siqi Yu, Lin Xu, Qinghua Wang, Lin Yang, Yi Su, Zhirou Xiong, Mengjie Shao, Meiyu Geng, Ao Zhang, Lei Zhang, Jing Ai, Chunyong Ding   +12 more
doaj   +1 more source

Electrophysiology Models for End-Stage Renal Disease Maladaptations That Promote Asystole

Reviews in Cardiovascular Medicine
Many patients with chronic renal impairment experience cardiac comorbidities throughout their lives, and the incidence of electrophysiological demise for patients with terminal renal impairment requiring renal replacement therapy is higher than in ...
Ikeotunye Royal Chinyere
doaj   +1 more source

Angiotensinogen and Angiotensin II Type 1 Receptor Gene Polymorphisms and Changes in Repolarization Parameters in Elderly Chinese: A 4-Year Follow-up Study

Kaohsiung Journal of Medical Sciences, 2008
Ventricular repolarization abnormality plays a crucial role in cardiac arrhythmia. Polymorphisms in renin—angiotensin system genes are associated with occurrence of ventricular arrhythmia. We previously demonstrated that subjects carrying the angiotensin
Ya-Ting Lee, Herng-Chia Chiu, Ho-Ming Su, Wen-Chol Voon, Tsung-Hsien Lin, Wen-Ter Lai, Sheng-Hsiung Sheu   +6 more
doaj   +1 more source

Depolarization and repolarization dynamics after His‐bundle pacing: Comparison with right ventricular pacing and native ventricular conduction

Annals of Noninvasive Electrocardiology, 2022
Background The current study aimed to evaluate changes in electrical depolarization and repolarization parameters after His‐bundle pacing (HBP) compared with right ventricular pacing (RVP) and its association with ventricular arrhythmia (VA).
Satoshi Yanagisawa, Yasuya Inden, Ryo Watanabe, Naoki Tsurumi, Noriyuki Suzuki, Toshifumi Nakagomi, Masafumi Shimojo, Takashi Okajima, Shuro Riku, Koichi Furui, Kazumasa Suga, Rei Shibata, Toyoaki Murohara   +12 more
doaj   +1 more source

Altered excitation-contraction coupling in human chronic atrial fibrillation [PDF]

, 2012
This review focuses on the (mal)adaptive processes in atrial excitation-contraction coupling occurring in patients with chronic atrial fibrillation. Cellular remodeling includes shortening of the atrial action potential duration and effective refractory ...
Grandi, E., Pandit, S.V., Workman, A.J.
core   +1 more source

Temporal variability of T‐wave morphology and risk of sudden cardiac death in patients with coronary artery disease

Annals of Noninvasive Electrocardiology, 2021
Background The possible relationship between temporal variability of electrocardiographic spatial heterogeneity of repolarization and the risk of sudden cardiac death (SCD) in patients with coronary artery disease (CAD) is not completely understood ...
Janne T. Rahola, Antti M. Kiviniemi, Olavi H. Ukkola, Mikko P. Tulppo, M. Juhani Junttila, Heikki V. Huikuri, Tuomas V. Kenttä, Juha S. Perkiömäki   +7 more
doaj   +1 more source