Results 221 to 230 of about 781,740 (337)

472 Comparative Analysis of the Antiviral Properties and the Transcriptome of the Lambda-Interferons IL-28A and IL-29: Significant Differences in Gene Repression

, 2010
Julia Diegelmann, Florian Beigel, B Göke, Ralf Bartenschlager, Helmut M. Diepolder, Stephan Brand   +5 more
openalex   +1 more source

Carbon catabolite repression in Aspergillus nidulans involves deubiquitination [PDF]

, 2001
Robin Lockington, Joan M. Kelly
openalex   +1 more source

An Automated Organotypic SCN Culture System Revealing Novel Insights into VIP Regulation of Circadian Rhythm

Advanced Science, EarlyView.
An Automated ex vivo culture system BaSIC, tailored for SCN slices and cell culture, which automates medium exchange and ensures a stable internal environment is developed. BaSIC enables real‐time observation of tissue/cell responses to diverse but programmed stimuli.
Kui Han, Meimei Liao, Jingpeng Zhang, Ruoyu Zhong, Long Mei, Dapeng Ju, Eric Erquan Zhang, Yanyi Huang   +7 more
wiley   +1 more source

The Bidirectional Interaction Between NF-<i>κ</i>B and Glucocorticoid Receptor: Underlying Mechanisms of Chronic Stress-Induced Pathology. [PDF]

J Immunol Res
Yu HJ, Park HJ, Lee B, Hahm DH.
europepmc   +1 more source

Nuclear Factor I‐B Delays Liver Fibrosis by Inhibiting Chemokine Ligand 5 Transcription

Advanced Science, EarlyView.
This study identifies the transcription factor Nuclear Factor I‐B (NFIB) as a key suppressor of liver fibrosis. NFIB expression declines during hepatic stellate cell activation, and its overexpression reduces fibrosis in mice models. The mechanism involves NFIB directly repressing chemokine C─C motif ligand 5 (CCL5), thereby alleviating oxidative ...
Qianqian Chen, Fajuan Rui, Zhiwen Fan, Hongju Yang, Nan Geng, Chenqi Lu, Wenjing Ni, Yue Huan, Junping Shi, Chao Wu, Shengxia Yin, Wei An, Xia Lu, Qianwen Zhao, Jie Li   +14 more
wiley   +1 more source

Recruitment of transcriptional effectors by Cas9 creates <i>cis</i>-regulatory elements and demonstrates distance-dependent transcriptional regulation. [PDF]

iScience
Boulos J, Golov AK, Keren N, Erlich I, Shehadeh N, Avidan N, Kariti H, Sadeh O, Haimovich-Caspi L, Helms A, Kaplan N, Kehat I.   +11 more
europepmc   +1 more source

Genomics Insights Into High‐Latitude Adaptation of Tibetan Macaques

Advanced Science, EarlyView.
Tibetan macaques exhibit unique adaptations to cold, high‐latitude environments, including shortened tails and enhanced fat storage. Genomic analyses reveal a species‐specific TBX6 mutation linked to tail reduction and selection on lipid metabolism genes.
Rusong Zhang, Ying Hu, Yang Teng, Jiwei Qi, Yangzhen Ciren, Lin Zhang, Qiao Du, Wencai Xu, Liang Zhou, Zhenxin Fan, Jinchuan Xing, Ming Li, Jing Li   +12 more
wiley   +1 more source

Correction for Martinez-Corral et al., Emergence of activation or repression in transcriptional control under a fixed molecular context. [PDF]

Proc Natl Acad Sci U S A
europepmc   +1 more source

Correction: Cattini, P.A.; Jin, Y. Evidence for Pituitary Repression of the Human Growth Hormone-Related Placental Lactogen Genes and a Role for P Sequences. <i>Int. J. Mol. Sci.</i> 2025, <i>26</i>, 4421. [PDF]

Int J Mol Sci
Cattini PA, Jin Y.
europepmc   +1 more source

Aberrant SUMOylation Restricts the Targetable Cancer Immunopeptidome

Advanced Science, EarlyView.
Pharmacological SUMOylation inhibition (SUMOi) counteracts tumor immune evasion by unmasking an immunogenic HLA‐I peptide and neoepitope repertoire. By restoring HLA‐I ligand availability through increased antigen processing and presentation, enhanced proteasomal cleavage, and modulated TAP1 peptide affinity, SUMOi boosts tumor immunogenicity ...
Uta M. Demel, Anna Meurer, Badeel Kh. Q. Zaghla, Bilge Atay, Daniel Steiert, Luca V. Hummel, Konstandina Isaakidis, Chuanbing Zang, Michael Korenkov, Marlon Schielin, Schayan Yousefian, Shima Mecklenbräuker, Marieluise Kirchner, Simon Haas, Antonia Busse, Philipp Mertins, Stefan Müller, Matthias Wirth, Martin G. Klatt, Ulrich Keller   +19 more
wiley   +1 more source