Results 221 to 230 of about 405,671 (296)

Kinsenoside‐Loaded Microneedle Accelerates Diabetic Wound Healing by Reprogramming Macrophage Metabolism via Inhibiting IRE1α/XBP1 Signaling Axis

Advanced Science, EarlyView.
Gut metabolite trimethylamine N‐oxide accumulates in the diabetic wound area to amplify macrophage inflammation via enhancing glycolysis activities. Kinsenoside induces macrophage repolarization from M1 to M2 phenotype through inhibiting IRE1α/XBP1 pathway, followed by HIF‐1α‐glycolysis axis repression and mitophagy‐oxidative phosphorylation axis ...
Li Lu, Jiewen Liao, Chao Xu, Yuan Xiong, Juan Zhou, Guangji Wang, Ze Lin, Kangkang Zha, Chuanlu Lin, Ruiyin Zeng, Guandong Dai, Qian Feng, Bobin Mi, Guohui Liu   +13 more
wiley   +1 more source

Developing Quorum Sensing-Based Collaborative Dynamic Control System in Halomonas TD01. [PDF]

Adv Sci (Weinh)
Lin YN, Li YX, Zheng Y, Deng YH, Liu KX, Gan Y, Li H, Wang J, Peng JW, Deng RZ, Wang HM, Wang H, Ye JW.   +12 more
europepmc   +1 more source

Attenuated Nuclear Tension Regulates Progerin‐Induced Mechanosensitive Nuclear Wrinkling and Chromatin Remodeling

Advanced Science, EarlyView.
The premature aging‐related progerin leads to defective nuclear morphology and is associated with disrupted molecular coupling between the extranuclear cytoskeleton and lamin‐associated nuclear envelope. It is discovered that progerin expression reduces nuclear tension, forms nuclear wrinkling, and enhances chromatin dynamics, thereby regulating ...
Ji‐Eun Park, Juhyeon Jo, Kun Xu, Sun‐Ah Lee, Seong‐Beom Han, YigJi Lee, Won‐Ki Cho, Bo Li, Soo Hyun Kim, Dong‐Hwee Kim   +9 more
wiley   +1 more source

E6AP is essential for the proliferation of HPV-positive cancer cells by preventing senescence. [PDF]

PLoS Pathog
Avenhaus A, Velimirović M, Bulkescher J, Scheffner M, Hoppe-Seyler F, Hoppe-Seyler K.   +5 more
europepmc   +1 more source

The New State of the Art: Cas9 for Gene Activation and Repression

Molecular and Cellular Biology, 2015
Marie La Russa, Lei S. Qi
semanticscholar   +1 more source

DDX3 Regulates the Cap‐Independent Translation of the Japanese Encephalitis Virus via Its Interactions with PABP1 and the Untranslated Regions of the Viral Genome

Advanced Science, EarlyView.
Japanese encephalitis virus (JEV) employs a cap‐independent (CI) translation strategy to evade host translational shutoff. During the shut‐off of host cellular canonical translation, DEAD‐box protein 3 (DDX3) bind to JEV UTRs to establish a closed‐loop architecture, and its interaction with poly(A)‐binding protein 1 (PABP1) to form DDX3/PABP1/eIF4G ...
Chenxi Li, Linjie Zhang, Chenyang Tang, Xuan Chen, Jing Shi, Qingyu Li, Xue Jiao, Jinyao Guo, Bin Wang, Kefan Bu, Abdul Wahaab, Yuguo Yuan, Ming‐an Sun, Yanhua Li   +13 more
wiley   +1 more source

Engineering intercellular communication using M13 phagemid and CRISPR-based gene regulation for multicellular computing in Escherichia coli. [PDF]

Nat Commun
Kusumawardhani H, Zoppi F, Avendaño R, Schaerli Y.   +3 more
europepmc   +1 more source

Metastatic colonization requires the repression of the epithelial-mesenchymal transition inducer Prrx1.

Cancer Cell, 2012
Oscar H. Ocaña, R. Córcoles, A. Fabra, G. Moreno-Bueno, G. Moreno-Bueno, H. Acloque, Sonia Vega, Alejandro Barrallo-Gimeno, A. Cano, M. Nieto   +9 more
semanticscholar   +1 more source

Mechanical Stress Induced NOX2 Promotes Endothelial Dysfunction in Ventilator‐Induced Lung Injury: Potential Treatment with Quercetin

Advanced Science, EarlyView.
Abnormal mechanical stretch induced by mechanical ventilation (MV) disrupts endothelial junctions via the NOX2/ROS/CaMKII/ERK1/2 axis both in human aortic endothelial cells (HAECs) in vitro and in ventilator‐induced lung injury (VILI) in mice. Quercetin, an antioxidant predicted to bind to NOX2, can effectively prevent mechanical stretch‐induced ...
Tao Jiang, Yabing Zhang, Zhiye Guo, He Ren, Weiyi Hu, Qingping Yao, Yunlong Huo, Yingxin Qi, Kai Huang   +8 more
wiley   +1 more source

The highly rugged yet navigable regulatory landscape of the bacterial transcription factor TetR. [PDF]

Nat Commun
Westmann CA, Goldbach L, Wagner A.
europepmc   +1 more source