Results 51 to 60 of about 405,671 (296)

THREE MOMENTS TO THINK HISTORY - ARGENTINA 1966-1976

open access: yesClio: Revista de Pesquisa Histórica, 2008
This article presents some important elements to understanding the climate between the years 1966-1976. To that end states, such as thread, the actions of organizations of workers and revolutionary guerrilla groups and in that context.
Rosana Núbia Sorbille
doaj  

Inhibition of acyl‐CoA synthetase long‐chain isozymes decreases multiple myeloma cell proliferation and causes mitochondrial dysfunction

open access: yesMolecular Oncology, EarlyView.
Triacsin C inhibition of the acyl‐CoA synthetase long chain (ACSL) family decreases multiple myeloma cell survival, proliferation, mitochondrial respiration, and membrane potential. Made with Biorender.com. Multiple myeloma (MM) is an incurable cancer of plasma cells with a 5‐year survival rate of 59%.
Connor S. Murphy   +12 more
wiley   +1 more source

Polizei-Durchgangslager Bozen, 1944-45. Cenni di storia

open access: yesDiacronie. Studi di Storia Contemporanea, 2018
The purpose of this essay is to understand the operating mode of the Polizei-Durchgangslager Bozen (Bolzano) which started during the german occupation in spring 1944 until May 1945.
Carla Giacomozzi è Responsabile dell’Archivio Storico Città di Bolzano/Stadtarchiv Bozen
doaj  

Stochastic variation in the FOXM1 transcription program mediates replication stress tolerance

open access: yesMolecular Oncology, EarlyView.
Cellular heterogeneity is a major cause of drug resistance in cancer. Segeren et al. used single‐cell transcriptomics to investigate gene expression events that correlate with sensitivity to the DNA‐damaging drugs gemcitabine and prexasertib. They show that dampened expression of transcription factor FOXM1 and its target genes protected cells against ...
Hendrika A. Segeren   +4 more
wiley   +1 more source

Milieux et mouvements libertaires pendant la Seconde République et la Guerre Civile espagnole

open access: yesDiacronie. Studi di Storia Contemporanea, 2011
Anarchism is a political current that is distinguished by its diversity and heterogeneity. Yet, the libertarian circles have often been comprehended by historiography in a homogeneous way, contributing to reify their stories.
Arnaud Dolidier est doctorant à l’université Michel de Montaigne Bordeaux 3 avec une thèse intitulée : « Repartir à l’assaut du ciel ! Les mouvements libertaires durant la transition démocratique espagnole : ordre public et actions collectives (1975-1982) », sous la direction de M. François Godicheau. Domaine de recherche: histoire contemporaine de l’Espagne. Il a réalisé les Master 1 et Master 2 entre 2008 et 2010 sous la direction de M. Jean François Soulet et M. François Godicheau à l’université Toulouse 2 Le Mirail sur le thème : « La construction des identités collectives dans le milieu rural andalou pendant la Seconde République ». Il est membre de l’association « Adelante ».
doaj  

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini   +10 more
wiley   +1 more source

Drosophila DNA-Binding Proteins in Polycomb Repression

open access: yesEpigenomes, 2018
The formation of individual gene expression patterns in different cell types is required during differentiation and development of multicellular organisms.
Maksim Erokhin   +2 more
doaj   +1 more source

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

open access: yesMolecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair   +17 more
wiley   +1 more source

Beyond K's Specter: Chang-rae Lee’s <em>A Gesture Life</em>, Comfort Women Testimonies, and Asian American Transnational Aesthetics

open access: yesJournal of Transnational American Studies, 2011
<p>This essay argues that Chang-rae Lee’s novel A Gesture Life exemplifies both the conceptual gains and the potential pitfalls of current Asian American literature’s transnationalism.
Belinda Kong
doaj  

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