Results 231 to 240 of about 136,304 (310)

A unified computational framework for quantitative design and optimization of transcriptional regulation across bacterial species. [PDF]

Nucleic Acids Res
Wang T, Xie R, Ma Z, Chen Y.
europepmc   +1 more source

Visual Recovery Reflects Cortical MeCP2 Sensitivity in Rett Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rett syndrome (RTT) is a devastating neurodevelopmental disorder with developmental regression affecting motor, sensory, and cognitive functions. Sensory disruptions contribute to the complex behavioral and cognitive difficulties and represent an important target for therapeutic interventions.
Alex Joseph Simon, Nathalie Picard, Valeria d'Andrea, Enchi Chang, Joseph Leffler, Eleonora Centofante, Matthew Taylor, Francesca Bardi, Francesca Cavicchiolo, Takao K. Hensch, Stefano Panzeri, Chinfei Chen, Michela Fagiolini   +12 more
wiley   +1 more source

Crosstalk Between <i>Cis</i>-Regulatory Elements and Metabolism Reprogramming in Hepatocellular Carcinoma. [PDF]

Cancers (Basel)
Ren Y, Tang D, Ding X, He M.
europepmc   +1 more source

Inhibition of Classical and Alternative Complement Pathway by Ravulizumab and Eculizumab

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore the feasibility of classical (CH50) and alternative (AH50) complement pathway activity as potential biomarkers for treatment guidance and monitoring during therapy with ravulizumab in patients with generalized myasthenia gravis (gMG) and compare these to therapeutic drug monitoring under eculizumab.
Lea Gerischer, Frauke Stascheit, Maximilian Mönch, Paolo Doksani, Carla Dusemund, Meret Herdick, Philipp Mergenthaler, Maike Stein, Amani Suboh, Jutta Schröder‐Braunstein, Guido Wabnitz, Jan D. Lünemann, Sophie Lehnerer, Sarah Hoffmann, Andreas Meisel   +14 more
wiley   +1 more source

Topologically associating domains define the 3D genome architecture of mouse totipotent-like stem cells. [PDF]

J Biol Chem
Fu Y, Ma W, Han J, Zhang W, Zhang S, Chen Y, Qin Y, Li J, Zhai Z, Li P, Li W, Wang K, Ma Z, Yao Y, Zhao C, Wang B, Chai H, Ruan Y, Kuang J, Zhang Z, Pei D.   +20 more
europepmc   +1 more source

Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky, Cara Joyce, H. Jeremy Bockholt, Paul A. Rudnick, William H. Adams, Fiona McAllister, Justin W. Smock, Michael A. Newton, Jane S. Paulsen   +8 more
wiley   +1 more source

Advances in scCUT&Tag and computational analysis for single-cell gene regulatory element mapping. [PDF]

Brief Bioinform
Wu J, Wahiduzzaman M, Yin P, Sun P, Chen H, Ding Y, Wang J.   +6 more
europepmc   +1 more source

Lessons Learned From a Delayed‐Start Trial of Modafinil for Freezing of Gait in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Freezing of gait (FOG) in people with Parkinson's disease (PwPD) is debilitating and has limited treatments. Modafinil modulates beta/gamma band activity in the pedunculopontine nucleus (PPN), like PPN deep brain stimulation. We therefore tested the hypothesis that Modafinil would improve FOG in PwPD.
Tuhin Virmani, Lakshmi Pillai, Reid D. Landes, Aliyah Glover, Shannon Doerhoff, Jennifer Kleiner, Mitesh Lotia, Rohit Dhall, Edgar Garcia‐Rill   +8 more
wiley   +1 more source

Modelling transcriptional silencing and its coupling to 3D genome organisation.

Soft Matter
Semeraro M, Negro G, Marenduzzo D, Forte G.   +3 more
europepmc   +1 more source

Dynamic architecture of mammalian paternal chromatin: histone-to-protamine exchange and post-fertilization reprogramming. [PDF]

Epigenetics Chromatin
Firouzabadi AM, Fesahat F, Seifati SM.
europepmc   +1 more source