Results 131 to 140 of about 491,654 (394)

In vivo localization of DNA sequences and visualization of large-scale chromatin organization using lac operator/repressor recognition

Journal of Cell Biology, 1996
We report a new method for in situ localization of DNA sequences that allows excellent preservation of nuclear and chromosomal ultrastructure and direct, in vivo observations.
C. C. Robinett, A. Straight, Gang Li, C. Willhelm, G. Sudlow, A. Murray, A. Belmont   +6 more
semanticscholar   +1 more source

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

FEBS Open Bio, EarlyView.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi, Shunsuke Morioka, Keiko Morisawa, Kazutsugu Matsukawa, Shingo Ashida, Takeshi Suzuki, Shuji Sakamoto   +6 more
wiley   +1 more source

Repressor of temperate mycobacteriophage L1 harbors a stable C-terminal domain and binds to different asymmetric operator DNAs with variable affinity

Virology Journal, 2007
Background Lysogenic mode of life cycle of a temperate bacteriophage is generally maintained by a protein called 'repressor'. Repressor proteins of temperate lambdoid phages bind to a few symmetric operator DNAs in order to regulate their gene expression.
Mandal Nitai C, Das Malabika, Chanda Palas K, Chattoraj Partho, Bandhu Amitava, Ganguly Tridib, Sau Subrata   +6 more
doaj   +1 more source

Tuning transcriptional regulation through signaling: A predictive theory of allosteric induction

, 2017
Allosteric regulation is found across all domains of life, yet we still lack simple, predictive theories that directly link the experimentally tunable parameters of a system to its input-output response.
Barnes, Stephanie L., Belliveau, Nathan M., Chure, Griffin, Einav, Tal, Lewis, Mitchell, Phillips, Rob, Razo-Mejia, Manuel   +6 more
core  

A bidirectional fluorescent two-hybrid system for monitoring protein–protein interactions

, 2014
Two-hybrid systems have been the cornerstone of research into protein–protein interactions, but these systems typically rely on life/death reporters that put additional selective pressure on the host organism, and potentially lead to false positives ...
Nordgren, Ida Karin, Tavassoli, Ali
core   +1 more source

UBQLN4 Represses Homologous Recombination and Is Overexpressed in Aggressive Tumors [PDF]

, 2019
Ron D. Jachimowicz, Filippo Beleggia, Jörg Isensee, Bhagya Bhavana Velpula, Jonas Goergens, Matías A. Bustos, Markus Alexander Doll, Anjana Shenoy, Cintia Checa-Rodríguez, Janica L. Wiederstein, Keren Baranes‐Bachar, Christoph Bartenhagen, Falk Hertwig, Nizan Teper, Tomohiko Nishi, Anna Schmitt, Felix Distelmaier, Hermann‐Josef Lüdecke, Beate Albrecht, Marcus Krüger, Björn Schumacher, Tamar Geiger, Dave S.�B. Hoon, Pablo Huertas, Matthias Fischer, Tim Hucho, Martin Peifer, Yael Ziv, Hans Christian Reinhardt, Dagmar Wieczorek, Yosef Shiloh   +30 more
openalex   +1 more source

Pioglitazone plus (−)‐epigallocatechin gallate: a novel approach to enhance osteogenic performance in aged bone marrow mesenchymal stem cells

FEBS Open Bio, EarlyView.
Aged human bmMSCs are seeded in the scaffold. Osteoblastic induction can slightly increase cell's bone‐forming activity to produce bone‐like tissues, shown as the sporadic xylenol orange‐stained spots (the lower left image). Notably, pioglitazone plus EGCG co‐treatment dramatically increases cell's bone‐forming activity and bone‐like tissue production (
Ching‐Yun Chen, Jia‐Ci Jhang, Chun‐Yi Peng, Quốc Cường Nguyễn, Feng‐Huei Lin, Hung‐Ming Wu, Shankung Lin   +6 more
wiley   +1 more source

TMAO-Activated Hepatocyte-Derived Exosomes Impair Angiogenesis via Repressing CXCR4

, 2022
Xiang Liu, Yijia Shao, Jiazichao Tu, Jiapan Sun, Bing Dong, Zhichao Wang, Jianrong Zhou, Long Chen, Jun Tao, Jimei Chen   +9 more
openalex   +1 more source

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

Polycomb- and REST-associated histone deacetylases are independent pathways toward a mature neuronal phenotype

eLife, 2014
The bivalent hypothesis posits that genes encoding developmental regulators required for early lineage decisions are poised in stem/progenitor cells by the balance between a repressor histone modification (H3K27me3), mediated by the Polycomb Repressor ...
James C McGann, Jon A Oyer, Saurabh Garg, Huilan Yao, Jun Liu, Xin Feng, Lujian Liao, John R Yates III, Gail Mandel   +8 more
doaj   +1 more source